Variable efficiency of the thymidine kinase/ganciclovir system in human glioblastoma cell lines: Implications for gene therapy

Human Gene Therapy

Volumn 8, Issue 16, 1997, Pages 1945-1953

  Sturtz, Franck G ^a   Waddell, Karen ^a   Shulok, Janine ^a   Chen, Xiaozhuo ^a   Caruso, Manuel ^b   Sanson, Marc ^c   Snodgrass, H Ralph ^a   Platika, Doros ^d  

^a Progenitor Inc   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^d Ontogeny Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GANCICLOVIR; THYMIDINE KINASE;

ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; GENE THERAPY; GENE TRANSFER; GENETIC TRANSFECTION; GLIOBLASTOMA; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; NONHUMAN; RAT; TUMOR CELL LINE;

ANIMALIA; HERPES; HUMAN HERPESVIRUS 1;

EID: 0030699933     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1997.8.16-1945     Document Type: Article

References (8)

1. ABDALLAH, B., HASSAN, A., BENOIST, C., GOULA, D., BEHR, J.P., and DEMENEIX, B.A. (1996). A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: polyethylenimine. Hum. Gene Ther. 7, 1947-1954.
2. BARBA, D., HARDIN, J., RAY, J., and GAGE, F. (1993). Thymidine kinase-mediated killing of rat brain tumors. J. Neurosurg. 79, 729-735.
3. BECK, C., CAYEUX, S., LUPTO, S.D., DÖRKEN, B., and BLANKENSTEIN, T. (1995). The thymidine kinase/ganciclovir-mediated "suicide" effect is variable in different tumor cells. Hum. Gene Ther. 6, 1525-1530.
4. BI, W.L., PARYSEK, L.M., WARNICK, R., and STAMBROOK, P.J. (1993). In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSV-tk retroviral gene therapy. Hum. Gene Ther. 4, 725-731.
5. BOVIATSIS, E.J., CHASE, M., WEI, M.X., TAMIYA, T., HURFORD, R.K., KOWALL, N.W., TEPPER, R.I., BREAKFIELD, X.O., and CHIOCCA, E.A. (1994). Gene transfer into experimental brain tumors mediated by adenovirus, herpes simplex virus, and retrovirus vectors. Hum. Gene Ther. 5, 183-191.
6. BYRNES, A.P., MACLAREN, R.E., and CHARLTON, H.M. (1996). Immunological instability of persistent adenovirus vectors in the brain: peripheral exposure to vector leads to renewed inflammation, reduced gene expression and demyelination. J. Neurosci. 16, 3045-3055.
7. CARUSO, M., PANIS, Y., GAGANDEEP, S., HOUSSIN, D., SALZMANN, J.L., and KLATZMANN, D. (1993). Regression of established macroscopic liver metastases after in situ transduction of a suicide gene. Proc. Natl. Acad. Sci. USA 90, 7024-7028.
8. CHEN, S.H., SHINE, H.D., GOODMAN, J.C., GROSSMAN, R.G., and WOO, S.L.C. (1994a). Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. Proc. Natl. Acad. Sci. USA 91, 3054-3057.