Differential blockade of the antinociceptive effects of centrally administered cannabinoids by SR141716A

Journal of Pharmacology and Experimental Therapeutics

Volumn 286, Issue 3, 1998, Pages 1301-1308

  Welch, Sandra P ^a   Huffman, John W ^a   Lowe, John ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; ANANDAMIDE; CANNABINOID; CANNABINOID RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; DELTA8 TETRAHYDROCANNABINOL; DRONABINOL; DYNORPHIN; MORPHINE; OPIATE; RECEPTOR SUBTYPE; RIMONABANT; AMIDE; ANALGESIC AGENT; ARACHIDONIC ACID DERIVATIVE; DRUG RECEPTOR; PIPERIDINE DERIVATIVE; PYRAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; BINDING AFFINITY; BRAIN; DOSE RESPONSE; DRUG ANTAGONISM; DRUG INHIBITION; DRUG RECEPTOR BINDING; HYPOTHERMIA; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRATHECAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECTUM TEMPERATURE; REGULATORY MECHANISM; SPINAL CORD; TAIL FLICK TEST; ANIMAL; BODY TEMPERATURE; DRUG EFFECT; INSTITUTE FOR CANCER RESEARCH MOUSE; MALE; SECRETION;

ANALGESICS; ANIMALS; ARACHIDONIC ACIDS; BODY TEMPERATURE; BRAIN; CANNABINOIDS; DYNORPHINS; MALE; MICE; MICE, INBRED ICR; PIPERIDINES; POLYUNSATURATED ALKAMIDES; PYRAZOLES; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; SPINAL CORD;

EID: 0032160418     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. 9-tetrahydrocannabinol-induced responses and apparent agonist affinity. J Pharmacol Exp Ther 277:586-594.
2. D'Amour FE and Smith DL (19411 A method for determining loss of pain sensation. J Pharmacol Exp Ther 72:74-79.
3. Deadwyler SA, Hampson RE. Bennett B A, Edwards TA, Mu J, Pacheco MA, Ward SJ
4. and Childers SR (1993) Cannabinoids modulate potassium current in cultured hippocampal neurons. Receptors Channels 1:121-134.
5. Devane WA, Hanus L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, Gibson D, Mandelbaum A, Etinger A and Mechoulam R (1992) Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science (Wash DC) 258:1946-1949.
6. Dunnett CW (1955) A multiple comparison procedure for comparing several treatments with a control. J Am Stat Assoc 50:1096-1121.
7. 9-THC, CP 55,940 and WIN 55,212. J Pharmacol Ejcp Ther 271:1383-1390.
8. Felder CC, Briley EM, Axelrod J, Simpson JT, Mackie K and Devane WA (1993) Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction. Proc Natl Acad Sei USA 90:7656-7660.
9. Felder CC, Joyce KE, Briley EM, Mansouri J, Mackie K, Blond O, Lai Y, Ma AL and Mitchell RL (1995) Comparison of the pharmacology and signal transduction of the human CB1 and CB2 receptors. Mol Pharmacol 48:443-450.
10. Fride E (1995) Anandamides: Tolerance and cross-tolerance to A9-tetrahydrocannabinol. Brain Res 697:83-90.
11. Fride E, Barg J, Levy R, Saya D, Heldman E, Mechoulam R and Vogel Z (1995) Low doses of anandamides inhibit pharmacological effects of A9-tetrahydrocannabinol. J Pharmacol Exp Ther 272:699-707.
12. Gérard CM, Mollereau C, Vassart G and Parmentier M (1990) Nucleotide sequence of a human cannabinoid receptor cDNA. Nucleic Acids Res 18:7142.
13. Gilbert PE (1981) A comparison of THC, nantradol, nabilone, and morphine in the chronic spinal dog. J Clin Pharmacol 21:3118-3198.
14. Harris LS and Pierson AK (1964) Some narcotic antagonists in the benzomorphan series. J Pharmacol Exp Ther 143:141-148.
15. Herkenham M, Lynn AB, Little MD, Johnson MR, Melvin LS, DeCosta BR and Rice KC (1990) Cannabinoid receptor localization in the brain. Proc Natl Acad Sei USA 87:1932-1936.
16. Hirst RA, Almond SL and Lambert DG (1996) Characterization of the rat cerebellar CB1 receptor using SR141716A, a central cannabinoid receptor antagonist. Neurosci Lett 220:101-104.
17. Huffman JW, Yu S, Showalter V, Abood ME, Wiley JL, Compton DC, Martin BR, Bramblett RD and Reggio PH (1996) Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxy with high affinity for the CB2 receptor. J Med Chem 39:3875-3877.
18. Hylden JLK and Wilcox GL (1983) Pharmacological characterization of substance P-induced nociception in mice: Modulation by opioid and noradrenergic agonists at the spinal level. Ear J Pharmacol 67:313-404.
19. Litchfield ST and Wilcoxon F (1949) A simplified method of evaluating dose effect experiments. J Pharmacol Exp Ther 96:99-113.
20. Lichtman AH, Cook SA and Martin BR (1996) Investigation of the brain sites mediating cannabinoid-induced antinociception in rats: Evidence supporting periaquaductal gray involvement. J Pharmacol Exp Ther 276:585-593.
21. Lichtman AH, Dimen KR and Martin BR (1995) Systemic or intrahippocampal cannabinoid administration impairs spatial memory in rats. Psychopharmacology 119:282-290.
22. Lichtman AH and Martin BR (1991a) Spinal and supraspinal mechanisms of cannabinoid-induced antinociception. J Pharmacol Exp Ther 258:517-523.
23. 2-noradrenergic mechanism. Brain Res 559:309-314.
24. Mackie K, Devane WA and Hille B ( 1993) Anandamide, an endogenous cannabinoid, inhibits calcium currents as a partial agonist in N18 neuroblastoma cells. Mol Pharmacol 44:498-503.
25. Matsuda LA, Lolait SJ, Brownstein MJ, Young AC and Bonner TI (1990) Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature (Land) 346:561-564.
26. Mechoulam R, Hanus L and Martin BR (1994) Search for endogenous ligands of the cannabinoid receptor. Biochem Pharmacol 48:1537-1544.
27. Munro S, Thomas KL and Abu-Shaar M (1993) Molecular characterization of a peripheral receptor for cannabinoids. Nature (Land) 365:61-65.
28. Pedigo NW, Dewey WL and Harris LS (1975) Determination and characterization of the antinociceptive activity of intraventricularly administered acetylcholine in mice. J Pharmacol Exp Ther 193:845-852.
29. Pertwee RG, Fernando SR, Nash JE and Coutts AA (1996) Further evidence for the presence of CB1 receptors in the guinea-pig small intestine. Br J Pharmacol 118:2199-2205.
30. Pertwee R, Griffin G, Hanus L and Mechoulam R (1994) Effects of two endogenous fatty acid ethanolamides on mouse vasa deferentia. Eur J Pharmacol 259:115120.
31. Pugh G Jr, Abood ME and Welch SP (1995) Antisense oligodeoxynucleotides to the K-l receptor block A9-THC-induced antinociception. Brain Res 689:157-158.
32. Pugh G Jr, Mason DJ, Combs V and Welch SP (1997) Involvement of dynorphin B in the antinociceptive effects of the cannabinoid CP55.940 in the spinal cord. J Pharmacol Exp Ther 281:730-737.
33. Pugh G Jr, Smith P, Dombrowski D and Welch SP (1996) The role of endogenous opioids in enhancing the antinociception produced by the combination of A9-TrIC and morphine in the spinal cord. J Pharmacol Exp Ther 279:608-616.
34. Einaldi-Carmona M, Barth F, Heaulme M, Alonso R, Shire D, Congy C, Soubri P, Breliere JC and LeFur G (1995) Biochemical and pharmacological characterization of SR141716A, the first potent and selective brain cannabinoid receptor antagonist. Life Sei 56:1941-1947.
35. Rinaldi-Carmona M, Barth F, Shire D, Maruani J, Neliat G, Caput D, Soubrie P, Breliere J and Le Fur G (1994) SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Letts 350:240-244.
36. Rinaldi-Carmona M, Calandra B, Shire D, Bouaboula, Oustric D, Barth F, Casellas P, Ferrara P and LeFur G (1996a) Characterization of two cloned human CB1 cannabinoid receptor isoforms. J Pharmacol Exp Ther 278:871-878.
37. 3H] SR141716A, a selective brain (CB1) cannabinoid receptor antagonist, in rodent brain. Life Sei 58:1239-1247.
38. Shire D, Carillon C, Kaghad M, Calandra B, Rinaldi-Carmona M, LeFur G, Capu, D and Ferrara P (1995) An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing. J Biol Chem 270:3726-3731.
39. Showalter VM, Compton DR, Martin BR and Abood ME (1996) Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): Identification of cannabinoid receptor subtype selective ligands. J Pharmacol Exp Ther 278:989-999.
40. Smith PB, Compton DR, Welch SP, Razdan R, Mechoulam R and Martin BR (1994a) The pharmacological activity of anandamide, a putative endogenous cannabincid, in mice. J Pharmacol Exp Ther 270:219-227.
41. Smith PB and Martin BR (1992) Spinal mechanisms of A9-tetrahydrocannabinolinduced analgesia. Brain Res 578:8-12.
42. Smith PB, Welch SP and Martin BR (1994b) Interactions between A9-tetrahydrocannabinol and kappa opioids in mice. J Pharmacol Exp Ther 268:1381-1386.
43. Tallarida RJ and Murray RB (1987) Manual of Pharmacologie Calculations wth Computer Programs, 2nd ed, pp 16-18 and 26-31, Springer-Verlag, New York.
44. Welch SP (1993) Blockade of cannabinoid-induced antinociception by norbinaltorphimine, but not N,N-diallyl-tyrosine-Aib-phenylalaline-leucine, ICI 174,864 or naloxone in mice. J Pharmacol Exp Ther 265:633-640.
45. Welch SP (1997) Characterization of anandamide-induced tolerance: Comparison to A9-THC-induced interactions with dynorphinergic systems. Drug and Alcohol Dep 45:39-45.
46. Welch SP, Dunlow LD, Patrick GS and Razdan R (1995a) Characterization of anandamide- and fluoroanandamide-induced antinociception and cross-tolerance to A9-THC after intrathecal administration to mice: Blockade of A9-THC-induced antinociception. J Pharmacol Exp Ther 273:1235-1244.
47. Welch SP and Stevens DL (1992) Antinociceptive activity of intrathecally administered cannabinoids alone, and in combination with morphine, in mice. J Pharmacol Exp Ther 262:10-18.
48. Welch SP, Thomas C and Patrick GS (1995b) Modulation of cannabinoid-inducîd antinociception following intracerebroventricular versus intrathecal administration to mice: Possible mechanisms for interaction with morphine. J Pharmacol E.tp Ther 272:310-321.
49. Wiley J, Balster R and Martin BR (1995) Discriminative stimulus effects of anandamide in rats. Eur J Pharmacol 276:49-54.
50. Yaksh TL (1981) The antinociceptive effects of the intrathecally administered levonantradol and desacetyllevonantradol in the rat. J Clin Pharmacol 21:3348-3403.
51. Send reprint requests to: Dr. Sandra Welch, Box 980613, MCV Station, Richmond, VA 23298-0613.