The embryonic angiogenic factor Del1 accelerates tumor growth by enhancing vascular formation

Microvascular Research

Volumn 64, Issue 1, 2002, Pages 148-161

  Aoka, Yoshikazu ^a,b   Johnson, Frances L ^a   Penta, Kalyani ^a   Hirata, Ken Ichi ^a   Hidai, Chiaki ^b   Schatzman, Randall ^a   Varner, Judith A ^c   Quertermous, Thomas ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Angiogenesis factor; Cell death, integrins; Endothelium; Neovascularization; Pathologic; Vascular

Indexed keywords

ANGIOGENIC FACTOR; PROTEIN DEL1; UNCLASSIFIED DRUG; CARRIER PROTEIN; EDIL3 PROTEIN, HUMAN; EDIL3 PROTEIN, MOUSE; VITRONECTIN RECEPTOR;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CAPILLARY DENSITY; CARCINOGENESIS; CONTROLLED STUDY; CORRELATION ANALYSIS; EMBRYO; GENETIC ENGINEERING; GENETIC TRANSFECTION; GROWTH ACCELERATION; HUMAN; HUMAN CELL; IN VIVO STUDY; LEWIS CARCINOMA; MALE; MOUSE; NONHUMAN; NUDE MOUSE; OSTEOSARCOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TUMOR GROWTH; TUMOR MODEL; TUMOR VASCULARIZATION; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; CELL CULTURE; CELL DIVISION; FLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; METABOLISM; MITOSIS; NEOPLASM; NEOVASCULARIZATION (PATHOLOGY); PHYSIOLOGY; TIME; VASCULARIZATION; WESTERN BLOTTING;

MURINAE;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CARCINOMA, LEWIS LUNG; CARRIER PROTEINS; CELL DIVISION; HUMANS; IMMUNOHISTOCHEMISTRY; INTEGRIN ALPHAVBETA3; MALE; MICE; MICE, INBRED C57BL; MICE, NUDE; MICROSCOPY, FLUORESCENCE; MITOSIS; MODELS, BIOLOGICAL; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; TIME FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0036018745     PISSN: 00262862     EISSN: None     Source Type: Journal    
DOI: 10.1006/mvre.2002.2414     Document Type: Article

References (32)

1. Requirement of vascular integrin avb3 for angiogenesis
2. Integrin avb3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
3. Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin avb3
4. Expression of angiostatin cDNA in a murine fibrosarcoma suppresses primary tumor growth and produces long-term dormancy of metastases
5. Expression of vascular permeability factor/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis, and experimental metastasis
6. Growth advantage and vascularization induced by basic fibroblast growth factor overexpression in endometrial HEC-1-B cells: An export-dependent mechanism of action
7. Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis
8. An antagonist of integrin avb3 prevents maturation of blood vessels during embryonic neovascularization
9. Role of extracellular matrix in the action of basic fibroblast growth factor: Matrix as a source of growth factor for long-term stimulation of plasminogen activator production and DNA synthesis
10. Definition of two angiogenic pathways by distinct av integrins
11. Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development
12. Angiostatin gene transfer: Inhibition of tumor growth in vivo by blockage of endothelial cell proliferation associated with a mitosis arrest
13. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
14. Cloning and characterization of developmental endothelial locus-1: An embryonic endothelial cell protein that binds the avb3 integrin receptor
15. Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant
16. The rise and fall of apoptosis during multistage tumorigenesis: Down-modulation contributes to tumor progression from angiogenic progenitors
17. Endostatin: An endogenous inhibitor of angiogenesis and tumor growth
18. Angiostatin induces and sustains dormancy of human primary tumors in mice
19. Angiostatin: A circulating endothelial cell inhibitor that suppresses angiogenesis and tumor growth
20. Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma
21. Del1 induces integrin signaling and angiogenesis by ligation of avb3
22. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo
23. Mechanisms of angiogenesis
24. Inhibition of growth of C6 glioma cells in vivo by expression of antisense vascular endothelial growth factor sequence
25. Role of av integrins and vitronectin in human melanoma cell growth
26. Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the alphavbeta3 integrin, osteopontin, and thrombin
27. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
28. Vascular endothelial growth factor inhibits endothelial cell apoptosis induced by tumor necrosis factor-alpha: Balance between growth and death signals
29. Cell adhesion and angiogenesis
30. TIMP-2 over-expression reduces invasion and angiogenesis and protects B16F10 melanoma cells from apoptosis
31. Quantification of angiogenesis in solid human tumours: An international consensus on the methodology and criteria of evaluation
32. Transfection of thrombospondin 1 complementary DNA into a human breast carcinoma cell line reduces primary tumor growth, metastatic potential, and angiogenesis