Dual effect mediated by protease-activated receptors on the mechanical activity of rat colon

British Journal of Pharmacology

Volumn 136, Issue 3, 2002, Pages 367-374

  Mulè, Flavia ^a   Baffi, Maria Carmela ^b   Cerra, Maria Carmela ^b  

^a UNIVERSITY OF PALERMO   (Italy)

^b UNIVERSITY OF CALABRIA   (Italy)

Author keywords

Intestinal motility; Potassium channel; Protease activated receptor (PAR); Rat colon; Thrombin; Trypsin

Indexed keywords

PROSTAGLANDIN; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; THROMBIN; THROMBIN RECEPTOR; TRYPSIN; APAMIN; CALCIUM ION; DIGESTIVE TRACT AGENT; INDOMETACIN; POTASSIUM CHANNEL; PROSTAGLANDIN SYNTHASE; PROTEINASE ACTIVATED RECEPTOR 1 AGONIST; PROTEINASE ACTIVATED RECEPTOR 2 AGONIST; SERYLLEUCYLISOLEUCYLGLYCYLARGINYLLEUCINE; TETRODOTOXIN; THROMBIN RECEPTOR ACTIVATING PEPTIDE 6; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; COLON; DRUG EFFECT; DRUG POTENTIATION; GASTROINTESTINAL MOTILITY; IN VITRO STUDY; INNERVATION; MALE; MUSCLE ISOMETRIC CONTRACTION; PHYSIOLOGY; RAT; SMOOTH MUSCLE; STRUCTURE ACTIVITY RELATION; WISTAR RAT; ANIMAL TISSUE; COLITIS; COLON MOTILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; INTESTINE MUSCLE; INTESTINE PRESSURE; ISOLATED ORGAN; NERVE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE TONE;

ANIMALS; COLON; GASTROINTESTINAL MOTILITY; ISOMETRIC CONTRACTION; MALE; MUSCLE, SMOOTH; PROSTAGLANDINS; RATS; RATS, WISTAR; RECEPTOR, PAR-1; RECEPTOR, PAR-2; RECEPTORS, THROMBIN; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN; TRYPSIN; ANIMAL; IN VITRO; SUPPORT, NON-U.S. GOV'T;

EID: 0036016106     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704746     Document Type: Article

References (41)

1. Detection of functional receptors for the proteinase-activated-receptor-2-activating polypeptide, SLIGRL-NH2, in rat vascular and gastric smooth muscle
2. Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2
3. Proteinase-activated receptors: Sentries for inflammation?
4. Protease-activated receptors mediate apamin-sensitive relaxation of mouse and guinea pig gastrointestinal smooth muscle
5. Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2
6. Thrombin and mast cell tryptase regulate guinea-pig myenteric neurons through proteinase-activated receptors-1 and -2
7. Proteinase-activated receptors: Novel mechanisms of signaling by serine proteases
8. Aminopeptidase modulation of the pharmacological responses to synthetic thrombin receptor agonists
9. Intestinal type 2 proteinase-activated receptors: Expression in opioid-sensitive secretomotor neural circuits that mediate epithelial ion transport
10. Protease-activated receptors: PAR-4 and counting: How long is the course
11. Role of the amino- and carboxyl-terminal domains of thrombin receptor-derived polypeptides in biological activity in vascular endothelium and gastric smooth muscle: Evidence for receptor subtypes
12. 2
13. Proteinase activated receptor: Structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor-activating peptides
14. Protease-activated receptor 3 is a second thrombin receptor in humans
15. Immunocytes and abnormal gastrointestinal motor activity during ileitis in dogs
16. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin
17. A dual thrombin receptor system for platelet activation
18. Dual modulation by thrombin of the motility off rat esophageal muscularis mucosae via two distinct protease-activated receptors (PARs): A novel role for PAR-4 as opposed to PAR-1
19. Characterization of protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle
20. In vivo evidence that protease-activated receptors 1 and 2 modulate gastrointestinal transit in the mouse
21. Modulation by protease-activated receptors of the rat duodenal motility in vitro: Possible mechanisms underlying the evoked contraction and relaxation
22. Evaluation of proteinase-activated receptor-1 (PAR-1) agonists and antagonists using a cultured cell receptor desensitization assay: Activation of PAR-2 by PAR-1 targeted ligands
23. Luminal trypsin may regulate enterocytes through proteinase-activated receptor 2
24. Proteinase-activated receptors
25. Interactions of mast cell tryptase with thrombin receptors and PAR-2
26. Modulation by nitric oxide of spontaneous mechanical activity in rat proximal colon
27. + channels
28. Neurotensin: Dual effect on the motor activity of rat duodenum
29. Inhibition of mechanical activity by neurotensin in rat proximal colon: Involvement of nitric oxide
30. Motility pattern of isolated proximal colon and excitatory action of neurotensin
31. Molecular cloning of a potential proteinase activated receptor
32. Rat proteinase-activated receptor-2 (PAR-2): Cdna sequence and activity of receptor-derived peptides in gastric and vascular tissue
33. Apamin-sensitive and -insensitive components of inhibitory junction potentials in rat caecum: Role of nitric oxide
34. Evidence that PAR-1 and PAR-2 mediate prostanoid-dependent contraction in isolated guinea-pig gallbladder
35. Proteinase-activated receptors - Novel signals for gastrointestinal pathophysiology
36. Proteinase-activated receptor-2-activating peptides: Identification of a receptor that regulates intestinal transport
37. Protease-activated receptors in inflammation, neuronal signaling and pain
38. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
39. Enteric neuropathobiology
40. Cloning and characterization of human protease-activated receptor 4
41. Parallel contractile signal transduction pathways activated by receptors for thrombin and epidermal growth factor-urogastrone in guinea pig gastric smooth muscle: Blockade by inhibitors of mitogen-activated protein kinase-kinase and phosphatidyl inositol 3′-kinase