MntR modulates expression of the PerR regulon and superoxide resistance in Staphylococcus aureus through control of manganese uptake

Molecular Microbiology

Volumn 44, Issue 5, 2002, Pages 1269-1286

  Horsburgh, Malcolm J ^a   Wharton, Stephen J ^a   Cox, Alan G ^a   Ingham, Eileen ^b   Peacock, Sharon ^c   Foster, Simon J ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CARRIER PROTEIN; CATALASE; FERRIC UPTAKE REGULATOR; FERRITIN; MANGANESE; MANGANESE TRANSPORTER PROTEIN; PEROXIDE RESISTANCE REGULON REPRESSOR; PROTEIN MNTR; REGULATOR PROTEIN; SUPEROXIDE; UNCLASSIFIED DRUG; HERBICIDE; HYBRID PROTEIN; MNTR PROTEIN, BACTERIA; PARAQUAT; PERR REPRESSOR PROTEIN, BACTERIA; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR;

ABSCESS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GENE; BACTERIAL INFECTION; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM MUTANT; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE LOCUS; GROWTH RETARDATION; HOMEOSTASIS; ION TRANSPORT; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; STAPHYLOCOCCUS AUREUS; ANIMAL; BAGG ALBINO MOUSE; CYTOLOGY; DRUG EFFECT; GENETICS; HUMAN; METABOLISM; MICROBIOLOGY; MOLECULAR GENETICS; MOUSE; NUCLEOTIDE SEQUENCE; PATHOGENICITY; PROMOTER REGION; REGULON; REPORTER GENE; VASCULAR ENDOTHELIUM;

ANIMAL; BACTERIAL PROTEINS; BASE SEQUENCE; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; GENES, REPORTER; HERBICIDES; HOMEOSTASIS; HUMAN; MANGANESE; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PARAQUAT; PROMOTER REGIONS (GENETICS); RECOMBINANT FUSION PROTEINS; REGULON; REPRESSOR PROTEINS; STAPHYLOCOCCUS AUREUS; SUPEROXIDES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; ANIMALS; HUMANS; TRANSCRIPTION FACTORS;

ANIMALIA; BACTERIA (MICROORGANISMS); MURINAE; POSIBACTERIA; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

EID: 0036015643     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2002.02944.x     Document Type: Article

References (65)

1. Manganese: Its acquisition by and function in the lactic acid bacteria
2. Manganese acquisition by Lactobacillus plantarum
3. Manganese and defenses against oxygen toxicity in Lactobacillus plantarum
4. The scavenging of superoxide radical by manganous complexes in vitro
5. Investigations of the state of manganese in Lactobacillus plantarum
6. The Yfe system of Yersinia pestis transports iron and manganese and is required for full virulence of plague
7. Sequence heterogeneity of PsaA, a 37-kilodalton putative adhesin essential for virulence of Streptococcus pneumoniae
8. Bacillus subtilis contains multiple Fur homologues: Identification of the iron uptake (Fur) and peroxide regulon (PerR) repressors
9. FimA, a major virulence factor associated with Streptococcus parasanguis endocarditis
10. Polyphyletic origins of bacterial Nramp transporters
11. Coordinate regulation of virulence genes in Listeria monocytogenes requires the product of the prfA gene
12. B controls the environmental stress response but not starvation survival or pathogenicity in a mouse abscess model
13. Coordinate regulation of Bacillus subtilis peroxide stress genes by hydrogen peroxide and metal ions
14. A new family of high-affinity ABC manganese and zinc permeases
15. Characterization of the major superoxide dismutase of Staphylococcus aureus and its role in starvation survival, stress resistance, and pathogenicity
16. Antioxidant effect of manganese
17. Molecular cloning of a 32-kilodalton lipoprotein component of a novel iron-regulated Staphylococcus epidermidis ABC transporter
18. Characterization of the primary sigma factor of Staphylococcus aureus
19. Genomic organization of the mycobacterial sigma factor gene cluster
20. Phosphorous-31 and carbon-13 nuclear magnetic resonance studies of anaerobic glucose metabolism and lactate transport in Staphylococcus aureus cells
21. 31P-NMR and ESR studies of the oxidation states of manganese in Staphylococcus aureus
22. Molecular characterization and functional analysis of the major autolysin of Staphylococcus aureus 8325/4
23. Identification of a zinc-specific metalloregulatory protein, Zur, controlling zinc transport operons in Bacillus subtilis
24. The Mycobacterium tuberculosis IdeR is a dual functional regulator that controls transcription of genes involved in iron acquisition, iron storage and survival in macrophages
25. Antibiotic resistance cassettes for Bacillus subtilis
26. Iron and metal regulation in bacteria
27. Roles of metal ions and hydrogen peroxide in modulating the interaction of the Bacillus subtilis PerR peroxide regulon repressor with operator DNA
28. Using PCR to engineer DNA
29. SirR, a novel iron-dependent repressor in Staphylococcus epidermidis
30. M, an ECF RNA polymerase sigma factor of Bacillus subtilis 168, is essential for growth and survival in high concentrations of salt
31. PerR controls oxidative stress resistance and iron storage proteins and is required for virulence in Staphylococcus aureus
32. In Staphylococcus aureus, Fur is an interactive regulator with PerR, contributes to virulence, and is necessary for oxidative stress resistance through positive regulation of catalase and iron homeostasis
33. SodA and manganese are essential for resistance to oxidative stress in growing and sporulating cells of Bacillus subtilis
34. Out of the iron age: New insights into the critical role of manganese homeostasis in bacteria
35. 2+) permease in Streptococcus gordonii is regulated by a diphtheria toxin metallorepressor-like protein ScaR
36. Manganese
37. The NRAMP proteins of Salmonella typhimurium and Escherichia coli are selective manganese transporters involved in the response to reactive oxygen
38. Analysis of transcriptional control of the gerD spore germination gene of Bacillus subtilis 168
39. 2+ uptake
40. zur: A Zn(2+)-responsive regulatory element of Staphylococcus aureus
41. Staphylococcus aureus infections
42. Identification of the Escherichia coli K-12 Nramp orthologue (MntH) as a selective divalent metal ion transporter
43. Fibronectin-binding protein A of Staphylococcus aureus has multiple, substituting, binding regions that mediate adherence to fibronectin and invasion of endothelial cells
44. Genetic systems in staphylococci
45. Transition metals in control of gene expression
46. 2+ transporter in Escherichia coli
47. Bacterial fibronectin-binding proteins and endothelial cell surface fibronectin mediate adherence of Staphylococcus aureus to resting human endothelial cells
48. Cadmium and manganese transport in Staphylococcus aureus membrane vesicles
49. Lack of a role for iron in the Lyme disease pathogen
50. Characterization of a manganese-dependent regulatory protein, TroR, from Treponema pallidum
51. Manganese homeostasis in Bacillus subtilis is regulated by MntR, a bifunctional regulator related to the diphtheria toxin repressor family of proteins
52. Improved methods for electroporation of Staphylococcus aureus
53. Cloning, sequence, and footprint analysis of two promoter/operators from Corynebacterium diphtheriae that are regulated by the diphtheria toxin repressor (DtxR) and iron
54. Molecular genetics of heavy metal resistance systems in Staphylococcus aureus plasmids
55. In vivo testing of an Enterococcus faecalis efaA mutant and use of efaA homologs for species identification
56. Genetic studies on plasmid-linked cadmium resistance in Staphylococcus aureus
57. Manganese-dependent disproportionation of hydrogen peroxide in bicarbonate buffer
58. New shuttle vectors for Bacillus subtilis and Escherichia coli which allow rapid detection of inserted fragments
59. Iron, DtxR, and regulation of diphtheria toxin expression
60. Accumulation of manganese in Neisseria gonorrhoeae correlates with resistance to oxidative killing by superoxide anion and is independent of superoxide dismutase activity
61. Identification and characterisation of a second superoxide dismutase gene (sodM) from Staphylococcus aureus
62. Iron uptake mechanisms of pathogenic bacteria
63. Role of manganese-containing superoxide dismutase in oxidative stress and virulence of Streptococcus pneumoniae
64. Recent advances in the understanding of the biological chemistry of manganese