Amino acids in SRS1 and SRS6 are critical for furanocoumarin metabolism by CYP6B1v1, a cytochrome P450 monooxygenase

Insect Molecular Biology

Volumn 11, Issue 2, 2002, Pages 175-186

  Chen, J S ^a   Berenbaum, M R ^a   Schuler, M A ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Cytochrome P450 monooxygenases; Furanocoumarin metabolism; Homology modelling; Insect P450s

Indexed keywords

BACTERIA (MICROORGANISMS); INSECTA; LEPIDOPTERA; PAPILIO; PAPILIO POLYXENES;

5-METHOXYPSORALEN; AMINO ACID; BERGAPTEN; CYTOCHROME P450; DRUG DERIVATIVE; ISOPIMPINELLIN; METHOXSALEN; PSORALEN; PSORALEN DERIVATIVE; STEROID HORMONE 6 BETA HYDROXYLASE; STEROID HORMONE 6-BETA-HYDROXYLASE; STEROID MONOOXYGENASE; TRIOXYSALEN;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BUTTERFLY; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTAGENESIS; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; BUTTERFLIES; CYTOCHROME P-450 ENZYME SYSTEM; FICUSIN; METHOXSALEN; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUTAGENESIS; PSORALENS; SEQUENCE HOMOLOGY, AMINO ACID; STEROID HYDROXYLASES; TRIOXSALEN;

EID: 0036010998     PISSN: 09621075     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2583.2002.00323.x     Document Type: Article

References (56)

1. cam as revealed by site-directed mutagenesis
2. Coumarins
3. Comparative processing of allelochemicals in the Papilionidae (Lepidoptera)
4. Aromatic-aromatic interaction: A mechanism of protein structure stabilization
5. choP enzyme (CYP105C1)
6. Computer modeling of 3D structures of cytochrome P450s
7. Induction of cytochrome P450-mediated metabolism of xanthotoxin in the black swallowtail
8. A host-inducible cytochrome P450 from a host-specific caterpillar: Molecular cloning and evolution
9. eryF involved in erythromycin biosysnthesis
10. Evidence that aspartic acid 301 is a critical substrate-contact residue in the active site of cytochrome P450 2D6
11. Insect P450 enzymes
12. The molecular biology of cytochrome P450s
13. Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences
14. P450s: Structural similarities and function differences
15. Structure and function of cytochromes P450: A comparative analysis of three crystal structures
16. terp at 2.3 Å resolution
17. Isolation and characterization of CYP6B4, a furanocoumarin-inducible cytochrome P450 from a polyphagous caterpillar (Lepidoptera: Papilionidae)
18. CYP6B3: A second furanocoumarin-inducible cytochrome P450 expressed in Papilio polyxenes
19. Conserved promoter elements in the CYP6B gene family suggest common ancestry for cytochrome P450 monooxygenases mediating furanocoumarin detoxification
20. Differential induction of cytochrome P450 transcripts in Papilio polyxenes by linear and angular furanocoumarins
21. Aromatic-aromatic interactions in the zinc finger motif: Analysis of the two-dimensional nuclear magnetic resonance structure of a mutant domain
22. Mechanism-based inactivation of P450 2A6 by furanocoumarins
23. Molecular cloning and expression of CYP6B8: A xanthotoxin-inducible cytochrome P450 cDNA from Helicoverpa zea
24. Molecular analysis of multiple CYP6B genes from polyphagous Papilio species
25. Cytochrome P450 and actin genes expressed in Helicoverpa zea and Helicoverpa armigera: Paralogy/orthology identification, gene conversion, and evolution
26. BM-3
27. BM-3 haem domain complexed with the fatty acid substrate, palmitoleic acid
28. 15α gene
29. coh substrate specificity by mutation of a single amino-acid residue
30. Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression
31. Black swallowtail (Papilio polyxenes) alleles encode cytochrome P450s that selectively metabolize linear furanocoumarins
32. Metabolic interactions of methoxsalen and coumarin in humans and mice
33. cam
34. Structural flexibility and functional versatility of mammalian P450 enzymes
35. BM-3 changes substrate orientation in a catalytic intermediate and the regioselectivity of hydroxylation
36. The carbon monoxide-binding pigment of liver microsomes. II. Solubilization, purification and properties
37. Specificity of substrate and inhibitor probes for cytochrome P450s: Evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes
38. Cytochrome P450
39. cam
40. Isolation and characterization of two cytochrome P450 cDNA clones for CYP6B6 and CYP6B7 from Helicoverpa armigera (Hubner): Possible involvement of CYP6B7 in pyrethroid resistance
41. Crystal structure of hemoprotein domain of P450BM-3 a prototype for microsomal P450s
42. BM3, a single peptide cytochrome P450: NADPH-P450 reductase from Bacillus megaterium
43. Evaluation of comparative protein modeling by Modeller
44. Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents
45. Plant cytochrome P450 monooxygenases
46. Inhibitors of CYP6D1 in house fly microsomes
47. Prostacyclin synthase active sites. Identification by molecular modeling-guided site-directed mutagenesis
48. The interaction between phenylalanine rings in proteins
49. Cassette mutagenesis of a potential substrate recognition region of cytochrome P450 2C2
50. Differential effects of mutations in substrate recognition site 1 of cytochrome P450 2C2 on lauric acid and progesterone hydroxylation
51. Site-directed mutagenesis as a tool for molecular modeling of cytochrome P450 2B1
52. Structures of eukaryotic cytochrome P450 enzymes
53. Isolation and sequence analysis of a cDNA clone for a pyrethroid inducible cytochrome P450 from Helicoverpa armigera
54. Mammalian microsomal cytochrome P450 monooxygenase: Structural adaptations for membrane binding and functional diversity
55. Denaturation of cytochrome P450 2B1 by guanidine hydrochloride and urea: Evidence for a metastable intermediate state of the active site