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Volumn 15, Issue 2, 2002, Pages 123-130
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Development of selectivity of α1-antitrypsin variant by mutagenesis in its reactive site loop against proprotein convertase. A crucial role of the P4 arginine in PACE4 inhibition
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Author keywords
Furin; PACE4; PC6; Proprotein convertase; 1 antitrypsin
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Indexed keywords
ALPHA 1 ANTITRYPSIN;
ARGININE;
BACTERIAL TOXIN;
COMPLEMENT COMPONENT C3;
ENZYME VARIANT;
FURIN;
GROWTH FACTOR;
PROPROTEIN CONVERTASE;
PROTEIN PACE4;
SERINE PROTEINASE;
SUBTILISIN;
UNCLASSIFIED DRUG;
CADHERIN;
PCSK6 PROTEIN, HUMAN;
PCSK6 PROTEIN, RAT;
PRIMER DNA;
PROPROTEIN CONVERTASE 5;
RECOMBINANT PROTEIN;
SERINE PROTEINASE INHIBITOR;
ARTICLE;
CARCINOGENESIS;
COMPLEX FORMATION;
CONTROLLED STUDY;
EMBRYO;
ENZYME ACTIVE SITE;
ENZYME INHIBITION;
ENZYME SPECIFICITY;
ENZYME SUBSTRATE;
HUMAN;
HUMAN CELL;
MUTAGENESIS;
PRIORITY JOURNAL;
PROTEIN FAMILY;
PROTEIN TARGETING;
SENSITIVITY AND SPECIFICITY;
VIRUS REPLICATION;
ANIMAL;
CELL CULTURE;
CHEMISTRY;
DRUG ANTAGONISM;
DRUG EFFECT;
GENETIC TRANSFECTION;
GENETICS;
METABOLISM;
POLYMERASE CHAIN REACTION;
RAT;
SERODIAGNOSIS;
SITE DIRECTED MUTAGENESIS;
BACTERIA (MICROORGANISMS);
ALPHA 1-ANTITRYPSIN;
ANIMALS;
ARGININE;
CADHERINS;
DNA PRIMERS;
FURIN;
HUMANS;
MUTAGENESIS, SITE-DIRECTED;
POLYMERASE CHAIN REACTION;
PRECIPITIN TESTS;
PROPROTEIN CONVERTASE 5;
PROPROTEIN CONVERTASES;
RATS;
RECOMBINANT PROTEINS;
SERINE ENDOPEPTIDASES;
SERINE PROTEINASE INHIBITORS;
SUBTILISINS;
TRANSFECTION;
TUMOR CELLS, CULTURED;
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EID: 0036010133
PISSN: 02692139
EISSN: None
Source Type: Journal
DOI: 10.1093/protein/15.2.123 Document Type: Article |
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Times cited : (25)
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References (51)
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