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Volumn 121, Issue 5, 1997, Pages 941-948

A novel human PACE4 isoform, PACE4E is an active processing protease containing a hydrophobic cluster at the carboxy terminus

Author keywords

Kexin like protease; PACE4 isoform; PACE4E; Proprotein processing; Subtilisin like proprotein convertase 4

Indexed keywords

COMPLEMENTARY DNA; ISOENZYME; MESSENGER RNA; MUTANT PROTEIN; PROTEINASE; VON WILLEBRAND FACTOR;

EID: 0030920027     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a021677     Document Type: Article
Times cited : (28)

References (41)
  • 1
    • 0020008342 scopus 로고
    • Post-translational proteolysis in polypeptide hormone biosynthesis
    • Docherty, K. and Steiner, D.F. (1982) Post-translational proteolysis in polypeptide hormone biosynthesis. Annu. Rev. Physiol. 44, 625-638
    • (1982) Annu. Rev. Physiol. , vol.44 , pp. 625-638
    • Docherty, K.1    Steiner, D.F.2
  • 2
    • 0025733702 scopus 로고
    • Mammalian subtilisins: The long-sought dibasic processing endoproteases
    • Barr, P.J. (1991) Mammalian subtilisins: the long-sought dibasic processing endoproteases. Cell 66, 1-3
    • (1991) Cell , vol.66 , pp. 1-3
    • Barr, P.J.1
  • 3
    • 0025916877 scopus 로고
    • Arg-X-Lys/Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway
    • Hosaka, M., Nagahama, M., Kim, W.-S., Watanabe, T., Hatsuzawa, K., Ikemizu, J., Murakami, K., and Nakayama, K. (1991) Arg-X-Lys/Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway. J. Biol. Chem. 266, 12127-12130
    • (1991) J. Biol. Chem. , vol.266 , pp. 12127-12130
    • Hosaka, M.1    Nagahama, M.2    Kim, W.-S.3    Watanabe, T.4    Hatsuzawa, K.5    Ikemizu, J.6    Murakami, K.7    Nakayama, K.8
  • 4
    • 0021713896 scopus 로고
    • Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor
    • Julius, D., Brake, A., Blair, L., Kunisawa, R., and Thorner, J. (1984) Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor. Cell 37, 1075-1089
    • (1984) Cell , vol.37 , pp. 1075-1089
    • Julius, D.1    Brake, A.2    Blair, L.3    Kunisawa, R.4    Thorner, J.5
  • 5
    • 0023838558 scopus 로고
    • Enzymes required for yeast prohormone processing
    • Fuller, R.S., Sterne, R.E., and Thorner, J. (1988) Enzymes required for yeast prohormone processing. Annu. Rev. Physiol. 50, 345-362
    • (1988) Annu. Rev. Physiol. , vol.50 , pp. 345-362
    • Fuller, R.S.1    Sterne, R.E.2    Thorner, J.3
  • 7
    • 0024286214 scopus 로고
    • Yeast Kex2 genes encodes an endopeptidase homologous to subtilisin-like serine proteases
    • Mizuno, K., Nakamura, T., Ohshima, T., Tanaka, S., and Matsuo, H. (1988) Yeast Kex2 genes encodes an endopeptidase homologous to subtilisin-like serine proteases. Biochem. Biophys. Res. Commun. 156, 246-254
    • (1988) Biochem. Biophys. Res. Commun. , vol.156 , pp. 246-254
    • Mizuno, K.1    Nakamura, T.2    Ohshima, T.3    Tanaka, S.4    Matsuo, H.5
  • 8
    • 0024425494 scopus 로고
    • Intracellular targeting and structural conservation of a prohormone-processing endoprotease
    • Fuller, R.S., Brake, A.J., and Thorner, J. (1989) Intracellular targeting and structural conservation of a prohormone-processing endoprotease. Science 246, 482-486
    • (1989) Science , vol.246 , pp. 482-486
    • Fuller, R.S.1    Brake, A.J.2    Thorner, J.3
  • 10
    • 0025635768 scopus 로고
    • Structure and expression of mouse furin, a yeast Kex2-related protease: Lack of processing of coexpressed prorenin in GH4C1 cells
    • Hatsuzawa, K., Hosaka, M., Nakagawa, T., Nagase, M., Shoda, A., Murakami, K., and Nakayama, K. (1990) Structure and expression of mouse furin, a yeast Kex2-related protease: Lack of processing of coexpressed prorenin in GH4C1 cells. J. Biol. Chem. 265, 22075-22078
    • (1990) J. Biol. Chem. , vol.265 , pp. 22075-22078
    • Hatsuzawa, K.1    Hosaka, M.2    Nakagawa, T.3    Nagase, M.4    Shoda, A.5    Murakami, K.6    Nakayama, K.7
  • 11
    • 0025622849 scopus 로고
    • cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: Tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases
    • Seidah, N.G., Gaspar, L., Mion, P., Marcinkiewicz, M., Mbikay, M., and Chrétien, M. (1990) cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: Tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases. DNA Cell Biol. 9, 415-424
    • (1990) DNA Cell Biol. , vol.9 , pp. 415-424
    • Seidah, N.G.1    Gaspar, L.2    Mion, P.3    Marcinkiewicz, M.4    Mbikay, M.5    Chrétien, M.6
  • 12
    • 0026088633 scopus 로고
    • Identification of a cDNa encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans
    • Smeekens, S.P., Avruch, A.S., LaMendola, J., Chan, S.J., and Steiner, D.F. (1991) Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans. Proc. Natl. Acad. Sci. USA 88, 340-344
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 340-344
    • Smeekens, S.P.1    Avruch, A.S.2    Lamendola, J.3    Chan, S.J.4    Steiner, D.F.5
  • 13
    • 0025214491 scopus 로고
    • Identification of a human insulinoma cDNa encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2
    • Smeekens, S.P. and Steiner, D.F. (1990) Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2. J. Biol. Chem. 265, 2997-3000
    • (1990) J. Biol. Chem. , vol.265 , pp. 2997-3000
    • Smeekens, S.P.1    Steiner, D.F.2
  • 14
    • 0026348132 scopus 로고
    • Identification of a second human subtilisin-like protease gene in the fes/fps region of chromosome 15
    • Kiefer, M.C., Tucker, J.E., Joh, R., Landsberg, K.E., Saltman, D., and Barr, P.J. (1991) Identification of a second human subtilisin-like protease gene in the fes/fps region of chromosome 15. DNA Cell Biol. 10, 757-769
    • (1991) DNA Cell Biol. , vol.10 , pp. 757-769
    • Kiefer, M.C.1    Tucker, J.E.2    Joh, R.3    Landsberg, K.E.4    Saltman, D.5    Barr, P.J.6
  • 15
    • 0028026649 scopus 로고
    • PACE4: A subtilisin-like endoprotease prevalent in the anterior pituitary and regulated by thyroid status
    • Johnson, R.C., Darlington, D.N., Hand, T.A., Bloomquist, B.T., and Mains, R.E. (1994) PACE4: A subtilisin-like endoprotease prevalent in the anterior pituitary and regulated by thyroid status. Endocrinology 135, 1178-1185
    • (1994) Endocrinology , vol.135 , pp. 1178-1185
    • Johnson, R.C.1    Darlington, D.N.2    Hand, T.A.3    Bloomquist, B.T.4    Mains, R.E.5
  • 16
    • 0028572480 scopus 로고
    • PACE4a is a ubiquitous endoprotease that has similar but not identical substrate specificity to other Kex2-like processing endoproteases
    • Hosaka, M., Murakami, K., and Nakayama, K. (1994) PACE4A is a ubiquitous endoprotease that has similar but not identical substrate specificity to other Kex2-like processing endoproteases. Biomed. Res. 15, 383-390
    • (1994) Biomed. Res. , vol.15 , pp. 383-390
    • Hosaka, M.1    Murakami, K.2    Nakayama, K.3
  • 17
    • 0026660354 scopus 로고
    • Identification of the fourth member of the mammalian endoprotease family homologous to the yeast Kex2 protease: Its testis-specific expression
    • Nakayama, K., Kim, W.-S., Torii, S., Hosaka, M., Nakagawa, T., Ikemizu, J., Baba, T., and Murakami, K. (1992) Identification of the fourth member of the mammalian endoprotease family homologous to the yeast Kex2 protease: Its testis-specific expression. J. Biol. Chem. 267, 5897-5900
    • (1992) J. Biol. Chem. , vol.267 , pp. 5897-5900
    • Nakayama, K.1    Kim, W.-S.2    Torii, S.3    Hosaka, M.4    Nakagawa, T.5    Ikemizu, J.6    Baba, T.7    Murakami, K.8
  • 18
    • 0026785385 scopus 로고
    • Testicular expression of PC4 in the rat: Molecular diversity of a novel germ cell-specific Kex2/subtilisin-like proprotein convertase
    • Seidah, N.G., Day, R., Hamelin, J., Gasper, A., Collard, M.W., and Chrétien, M. (1992) Testicular expression of PC4 in the rat: Molecular diversity of a novel germ cell-specific Kex2/subtilisin-like proprotein convertase. Mol. Endocrinol. 6, 1559-1570
    • (1992) Mol. Endocrinol. , vol.6 , pp. 1559-1570
    • Seidah, N.G.1    Day, R.2    Hamelin, J.3    Gasper, A.4    Collard, M.W.5    Chrétien, M.6
  • 19
    • 0027419621 scopus 로고
    • Identification and functional expression of a new member of the mammalian Kex2-like processing endoprotease family: Its striking structural similarity to PACE4
    • Nakagawa, T., Hosaka, M., Torii, S., Watanabe, T., Murakami, K., and Nakayama, K. (1993) Identification and functional expression of a new member of the mammalian Kex2-like processing endoprotease family: Its striking structural similarity to PACE4. J. Biochem. 113, 132-135
    • (1993) J. Biochem. , vol.113 , pp. 132-135
    • Nakagawa, T.1    Hosaka, M.2    Torii, S.3    Watanabe, T.4    Murakami, K.5    Nakayama, K.6
  • 20
    • 0027274628 scopus 로고
    • cDNa structure of the mouse and rat subtilisin/kexin-like PC5: A candidate proprotein convertase expressed in endocrine and nonendocrine cells
    • Lusson, J., Vieau, D., Hamelin, J., Day, R., Chrétien, M., and Seidah, N.G. (1993) cDNA structure of the mouse and rat subtilisin/kexin-like PC5: A candidate proprotein convertase expressed in endocrine and nonendocrine cells. Proc. Natl. Acad. Sci. USA 90, 6691-6695
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 6691-6695
    • Lusson, J.1    Vieau, D.2    Hamelin, J.3    Day, R.4    Chrétien, M.5    Seidah, N.G.6
  • 23
    • 0029916795 scopus 로고    scopus 로고
    • cDNa structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases
    • Seidah, N.G., Hamelin, J., Mamarbachi, M., Dong, W., Tadros, H., Mbikay, M., Chrétien, M., and Day, R. (1996) cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases. Proc. Natl. Acad. Sci. USA 93, 3388-3393
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 3388-3393
    • Seidah, N.G.1    Hamelin, J.2    Mamarbachi, M.3    Dong, W.4    Tadros, H.5    Mbikay, M.6    Chrétien, M.7    Day, R.8
  • 24
    • 0029946619 scopus 로고    scopus 로고
    • SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis
    • Constam, D.B., Calfon, M., and Robertson, E.J. (1996) SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis. J. Cell Biol. 134, 181-191
    • (1996) J. Cell Biol. , vol.134 , pp. 181-191
    • Constam, D.B.1    Calfon, M.2    Robertson, E.J.3
  • 25
    • 0027965348 scopus 로고
    • The family of subtilisin/kexin like pro-protein and pro-hormone convertases: Divergent or shared functions
    • Seidah, N.G., Chrétien, M., and Day, R. (1994) The family of subtilisin/kexin like pro-protein and pro-hormone convertases: Divergent or shared functions. Biochimie 76, 197-209
    • (1994) Biochimie , vol.76 , pp. 197-209
    • Seidah, N.G.1    Chrétien, M.2    Day, R.3
  • 26
    • 0028943539 scopus 로고
    • Distinct mRNA expression of the highly homologous convertases PC5 and PACE4 in the rat brain and pituitary
    • Dong, W., Marcinkiewicz, M., Vieau, D., Chrétien, M., Seidah, N.G., and Day, R. (1995) Distinct mRNA expression of the highly homologous convertases PC5 and PACE4 in the rat brain and pituitary. J. Neurosci. 15, 1778-1796
    • (1995) J. Neurosci. , vol.15 , pp. 1778-1796
    • Dong, W.1    Marcinkiewicz, M.2    Vieau, D.3    Chrétien, M.4    Seidah, N.G.5    Day, R.6
  • 28
    • 0028837047 scopus 로고
    • Distribution of the kexin family proteases in pancreatic islets: PACE4C is specifically expressed in B cells of pancreatic islets
    • Nagamune, H., Muramatsu, K., Akamatsu, T., Tamai, Y., Izumi, K., Tsuji, A., and Matsuda, Y. (1995) Distribution of the kexin family proteases in pancreatic islets: PACE4C is specifically expressed in B cells of pancreatic islets. Endocrinology 136, 357-360
    • (1995) Endocrinology , vol.136 , pp. 357-360
    • Nagamune, H.1    Muramatsu, K.2    Akamatsu, T.3    Tamai, Y.4    Izumi, K.5    Tsuji, A.6    Matsuda, Y.7
  • 29
    • 0026095523 scopus 로고
    • Functional expression of furin demonstrating its intracellular localization and endoprotease activity for processing of proalbumin and complement pro-C3
    • Misumi, Y., Oda, K., Fujiwara, T., Takami, N., Tashiro, K., and Ikehara, Y. (1991) Functional expression of furin demonstrating its intracellular localization and endoprotease activity for processing of proalbumin and complement pro-C3. J. Biol. Chem. 266, 16954-16959
    • (1991) J. Biol. Chem. , vol.266 , pp. 16954-16959
    • Misumi, Y.1    Oda, K.2    Fujiwara, T.3    Takami, N.4    Tashiro, K.5    Ikehara, Y.6
  • 30
    • 0026754578 scopus 로고
    • Regulation of PACE propeptide-processing activity: Requirement for a post-endoplasmic reticulum compartment and autoproteolytic activation
    • Rehemtulla, A., Dorner, A.J., and Kaufman, R.J. (1992) Regulation of PACE propeptide-processing activity: Requirement for a post-endoplasmic reticulum compartment and autoproteolytic activation. Proc. Natl. Acad. Sci. USA 89, 8235-8239
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 8235-8239
    • Rehemtulla, A.1    Dorner, A.J.2    Kaufman, R.J.3
  • 31
    • 0029147725 scopus 로고
    • Structural elements that direct specific processing of different mammalian subtilisin-like prohormone convertases
    • Zhou, A., Paquet, L., and Mains, R.E. (1995) Structural elements that direct specific processing of different mammalian subtilisin-like prohormone convertases. J. Biol. Chem. 270, 21509-21516
    • (1995) J. Biol. Chem. , vol.270 , pp. 21509-21516
    • Zhou, A.1    Paquet, L.2    Mains, R.E.3
  • 32
    • 0022423469 scopus 로고
    • Construction of cDNA coding for human von Willebrand factor using antibody probes for colony-screening and mapping of the chromosomal gene
    • Verweij, C.L., de Vries, C.J., Distel, B., van Zonneveld, A.J., van Kessel, A.G., and van Mourik, J.A. (1985) Construction of cDNA coding for human von Willebrand factor using antibody probes for colony-screening and mapping of the chromosomal gene. Nucleic Acids Res. 13, 4699-4717
    • (1985) Nucleic Acids Res. , vol.13 , pp. 4699-4717
    • Verweij, C.L.1    De Vries, C.J.2    Distel, B.3    Van Zonneveld, A.J.4    Van Kessel, A.G.5    Van Mourik, J.A.6
  • 33
    • 0025315178 scopus 로고
    • Nucleotide and deduced amino acid sequence of rat complement C3
    • Misumi, Y., Shoda, M., and Ikehara, Y. (1990) Nucleotide and deduced amino acid sequence of rat complement C3. Nucleic Acids Res. 18, 2178
    • (1990) Nucleic Acids Res. , vol.18 , pp. 2178
    • Misumi, Y.1    Shoda, M.2    Ikehara, Y.3
  • 34
    • 0021770787 scopus 로고
    • High level transient expression of a chloramphenicol acetyltransferase gene by DEAE-dextran mediated DNa transfection coupled with a dimethyl sulfoxide or glycerol shock treatment
    • Lopata, M.A., Cleveland, D.W., and Sollner-Webb, B. (1984) High level transient expression of a chloramphenicol acetyltransferase gene by DEAE-dextran mediated DNA transfection coupled with a dimethyl sulfoxide or glycerol shock treatment. Nucleic Acids Res. 12, 5707-5717
    • (1984) Nucleic Acids Res. , vol.12 , pp. 5707-5717
    • Lopata, M.A.1    Cleveland, D.W.2    Sollner-Webb, B.3
  • 35
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 36
    • 0020475449 scopus 로고
    • A simple method for displaying the hydropathic character of a protein
    • Kyte, J. and Doolittle, R.F. (1982) A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157, 105-132
    • (1982) J. Mol. Biol. , vol.157 , pp. 105-132
    • Kyte, J.1    Doolittle, R.F.2
  • 37
    • 0027376534 scopus 로고
    • PACE4 is a member of the mammalian propeptidase family that has overlapping but not identical substrate specificity to PACE
    • Rehemtulla, A., Barr, P.J., Rhodes, C.J., and Kaufman, R.J. (1993) PACE4 is a member of the mammalian propeptidase family that has overlapping but not identical substrate specificity to PACE. Biochemistry 32, 11586-11590
    • (1993) Biochemistry , vol.32 , pp. 11586-11590
    • Rehemtulla, A.1    Barr, P.J.2    Rhodes, C.J.3    Kaufman, R.J.4
  • 38
    • 0028040786 scopus 로고
    • A novel member, PC7, of the mammalian kexin-like protease family: Homology to PACE4A, its brain specific expression and identification of isoforms. Biochem
    • Tsuji, A., Hine, C., Mori, K., Tamai, Y., Higashine, K., Nagamune, H., and Matsuda, Y. (1994) A novel member, PC7, of the mammalian kexin-like protease family: Homology to PACE4A, its brain specific expression and identification of isoforms. Biochem. Biophys. Res. Commun. 202, 1452-1459
    • (1994) Biophys. Res. Commun. , vol.202 , pp. 1452-1459
    • Tsuji, A.1    Hine, C.2    Mori, K.3    Tamai, Y.4    Higashine, K.5    Nagamune, H.6    Matsuda, Y.7
  • 39
    • 0027368472 scopus 로고
    • Comparative biosynthesis, covalent post-translational modifications and efficiency of prosegment cleavage of the prohormone convertases PC1 and PC2: Glycosylation, sulphation and identification of the intracellular site of prosegment cleavage of PC1 and PC2
    • Benjannet, S., Rondeau, N., Paquet, L., Boudreault, A., Lazure, C., Chrétien, M., and Seidah, N.G. (1993) Comparative biosynthesis, covalent post-translational modifications and efficiency of prosegment cleavage of the prohormone convertases PC1 and PC2: Glycosylation, sulphation and identification of the intracellular site of prosegment cleavage of PC1 and PC2. Biochem. J. 294, 735-743
    • (1993) Biochem. J. , vol.294 , pp. 735-743
    • Benjannet, S.1    Rondeau, N.2    Paquet, L.3    Boudreault, A.4    Lazure, C.5    Chrétien, M.6    Seidah, N.G.7
  • 40
    • 0028107656 scopus 로고
    • Intracellular trafficking and activation of the furin proprotein convertase: Localization to the TGN and recycling from the cell surface
    • Molloy, S.S., Thomas, L., VanSlyke, J.K., Stenberg, P.E., and Thomas, G. (1994) Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface. EMBO J. 13, 18-33
    • (1994) EMBO J. , vol.13 , pp. 18-33
    • Molloy, S.S.1    Thomas, L.2    Vanslyke, J.K.3    Stenberg, P.E.4    Thomas, G.5
  • 41
    • 0030605010 scopus 로고    scopus 로고
    • Functional analysis of human PACE4-a and PACE4. C isoforms: Identification of a new PACE4-CS isoform
    • Zhong, M., Benjannet, S., Lazure, C., Munzer, S., and Seidah, N.G. (1996) Functional analysis of human PACE4-A and PACE4. C isoforms: Identification of a new PACE4-CS isoform. FEBS Lett. 396, 31-36
    • (1996) FEBS Lett. , vol.396 , pp. 31-36
    • Zhong, M.1    Benjannet, S.2    Lazure, C.3    Munzer, S.4    Seidah, N.G.5


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