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Volumn 335, Issue 1, 2002, Pages 7-14

Synthesis of imidazo[2,1-a]phthalazines, potential inhibitors of p38 MAP kinase. Prediction of binding affinities of protein ligands

(10) Aguirre, Gabriela a Cerecetto, Hugo a Di Maio, Rossanna a González, Mercedes a Porcal, Williams a Seoane, Gustavo a Ortega, Miguel A b Aldana, Ignacio b Monge, Antonio b Denicola, Ana c

a UNIVERSIDAD DE LA REPÚBLICA (Uruguay)

b UNIVERSITY OF NAVARRA (Spain)

c UNIVERSIDAD DE LA REPÚBLICA (Uruguay)

Author keywords

Imidazophthalazine; Molecular modeling; p38 MAPK; Suzuki coupling

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; IMIDAZO[2,1 A]PHTHALAZINE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHTHALAZINE DERIVATIVE; UNCLASSIFIED DRUG; ENZYME INHIBITOR; IMIDAZOLE DERIVATIVE; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38;

ARTICLE; BINDING AFFINITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; MOLECULAR MODEL; PHARMACOPHORE; PRIORITY JOURNAL; BINDING SITE; CHEMISTRY; DRUG ANTAGONISM; HUMAN; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

BINDING SITES; ENZYME INHIBITORS; HUMAN; IMIDAZOLES; LIGANDS; MITOGEN-ACTIVATED PROTEIN KINASES; PHTHALAZINES; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; HUMANS; P38 MITOGEN-ACTIVATED PROTEIN KINASES;

EID: 0036009203 PISSN: 03656233 EISSN: None Source Type: Journal
DOI: 10.1002/1521-4184(200201)335:1<7::AID-ARDP7>3.0.CO;2-L Document Type: Article

Times cited : (13)

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