C→U editing of neurofibromatosis 1 mrna occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRna-editing enzyme

American Journal of Human Genetics

Volumn 70, Issue 1, 2002, Pages 38-50

  Mukhopadhyay, Debnath ^a   Anant, Shrikant ^a   Lee, Robert M ^a   Kennedy, Susan ^a   Viskochil, David ^b   Davidson, Nicholas O ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B; APOLIPOPROTEIN B MRNA EDITING ENZYME; MESSENGER RNA; PROTEIN SUBUNIT; RNA; RNA BINDING PROTEIN; RNA BINDING PROTEINS; CYTOSINE; DEAMINASE; RECOMBINANT ENZYME; URACIL;

ADENOVIRUS; ALTERNATIVE RNA SPLICING; ARTICLE; CELL CULTURE; COLON TUMOR; EXON; GENE DELETION; GENETICS; HUMAN; METABOLISM; NERVE SHEATH TUMOR; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; RNA EDITING; SEQUENCE ALIGNMENT; TUMOR SUPPRESSOR GENE; ULTRAVIOLET RADIATION; CELL STRAIN HEPG2; CLINICAL ARTICLE; CONTROLLED STUDY; DEAMINATION; ENZYME ACTIVE SITE; GENE EXPRESSION; GENETIC HETEROGENEITY; GENETIC TRANSFECTION; HUMAN CELL; HUMAN TISSUE; NEUROFIBROMATOSIS; PRIORITY JOURNAL; RNA SEQUENCE; SEQUENCE ANALYSIS;

ADENOVIRIDAE; ALTERNATIVE SPLICING; APOLIPOPROTEINS B; BASE SEQUENCE; COLONIC NEOPLASMS; EXONS; GENES, NEUROFIBROMATOSIS 1; HUMAN; NERVE SHEATH TUMORS; PROTEIN SUBUNITS; RNA EDITING; RNA, MESSENGER; RNA, NEOPLASM; RNA-BINDING PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE DELETION; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED; ULTRAVIOLET RAYS;

ADENOVIRIDAE; MAMMALIA;

EID: 0036006807     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/337952     Document Type: Article

References (54)

1. An AU-rich sequence element (UUUN[A/U]U) downstream of the edited C in apolipoprotein B mRNA is a high-affinity binding site for Apobec-1: Binding of Apobec-1 to this motif in the 3′ untranslated region of c-myc increases mRNA stability
2. Apobec-1, the catalytic subunit of the mammalian apolipoprotein B mRNA editing enzyme, is a novel RNA-binding protein
3. Evolutionary origins of the mammalian apolipoprotein B RNA editing enzyme, apobec-1: Structural homology inferred from analysis of a cloned chicken small intestinal cytidine deaminase
4. Mutations in the neurofibromatosis 1 gene in sporadic malignant melanoma cell lines
5. Mutations affecting mRNA splicing are the most common molecular defects in patients with neurofibromatosis type 1
6. Gene regulation by mRNA editing
7. Only cytidines 5′ of the apolipoprotein B mRNA mooring sequence are edited
8. Three distinct RNA sequence elements are required for efficient apolipoprotein B (apoB) RNA editing in vitro
9. Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients
10. Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells
11. A potential role for NF1 mRNA editing in the pathogenesis of NF1 tumors
12. Apolipoprotein B-48 is the product of a messenger RNA with an organ-specific in-frame stop codon
13. NF1 tumor suppressor gene function: Narrowing the GAP
14. Learning deficits, but normal development and tumor predisposition, in mice lacking exon 23a of Nf1
15. Apolipoprotein B: mRNA editing, lipoprotein assembly, and presecretory degradation
16. Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis
17. Induction of RNA editing at heterologous sites by sequences in apolipoprotein B mRNA
18. Tissue-specific, developmental and nutritional regulation of the gene encoding the catalytic subunit of the rat apolipoprotein B mRNA editing enzyme: Functional role in the modulation of apoB mRNA editing
19. Complementation of apolipoprotein B mRNA editing by human liver accompanied by secretion of apolipoprotein B48
20. Apolipoprotein B mRNA editing in 12 different mammalian species: Hepatic expression is reflected in low concentrations of apoB-containing plasma lipoproteins
21. Absence of APOBEC-1 mediated mRNA editing in human carcinomas
22. Ras-GTP levels are elevated in human NF1 peripheral nerve tumors
23. Molecular cloning of a human small intestinal apolipoprotein B mRNA editing protein
24. Two efficiency elements flanking the editing site of cytidine 6666 in the apolipoprotein B mRNA support mooring-dependent editing
25. Cloning and characterization of the rat apobec-1 gene: A comparative analysis of gene structure and promoter usage in rat and mouse
26. Targeted disruption of the mouse apobec-1 gene abolishes apolipoprotein B mRNA editing and eliminates apolipoprotein B48
27. Hepatic expression of the catalytic subunit of the apolipoprotein B mRNA editing enzyme (apobec-1) ameliorates hypercholesterolemia in LDL receptor-deficient rabbits
28. Loss of neurofibromin is associated with activation of RAS/MAPK and PI3-K/AKT signaling in a neurofibromatosis 1 astrocytoma
29. Dimeric structure of a human apolipoprotein B mRNA editing protein and cloning and chromosomal localization of its gene
30. An alternatively spliced form of apobec-1 messenger RNA is overexpressed in human colon cancer
31. Purification and molecular cloning of a novel essential component of the apolipoprotein B mRNA editing enzyme-complex
32. Genomic organization of the neurofibromatosis 1 gene (NF1)
33. Changing genetic information through RNA editing
34. Mutagenesis of apobec-1, the catalytic subunit of the mammalian apolipoprotein B mRNA editing enzyme, reveals distinct domains that mediate cytosine nucleoside deaminase, RNA binding, and RNA editing activity
35. Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1
36. Molecular cloning of apobec-1 complementation factor, a novel RNA-binding protein involved in the editing of apolipoprotein B mRNA
37. Apolipoprotein B RNA editing enzyme-deficient mice are viable despite alterations in lipoprotein metabolism
38. Suppression of oncogenic Ras by mutant neurofibromatosis type 1 genes with single amino acid substitutions
39. Alternative mRNA splicing and differential promoter utilization determine tissue-specific expression of the apolipoprotein B mRNA-editing protein (Apobec1) gene in mice: Structure and evolution of Apobec1 and related nucleoside/nucleotide deaminases
40. Neurofibromatosis: Conference statement
41. Neurofibromatosis type 1 (NF1): A protein truncation assay yielding identification of mutations in 73% of patients
42. A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestine
43. Two distinct TATA-less promoters direct tissue-specific expression of the rat apo-B editing catalytic polypeptide 1 gene
44. Regulation of alternative splicing by RNA editing
45. Sequence requirements for the editing of apolipoprotein B mRNA
46. Single cell Ras-GTP analysis reveals altered Ras activity in a subpopulation of neurofibroma Schwann cells but not fibroblasts
47. RNA processing and clinical variability in neurofibromatosis type I (NF1)
48. The neurofibromatosis type I messenger RNA undergoes base-modification RNA editing
49. Tumour suppressor genes in disease and therapy
50. Overexpression of APOBEC-1 results in mooring sequence-dependent promiscuous RNA editing
51. Molecular cloning of an apolipoprotein B messenger RNA editing protein
52. A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme
53. Cloning and mutagenesis of the rabbit ApoB mRNA editing protein: A zinc motif is essential for catalytic activity, and noncatalytic auxiliary factor(s) of the editing complex are widely distributed
54. Hyperediting of multiple cytidines of apolipoprotein B mRNA by APOBEC-1 requires auxiliary protein(s) but not a mooring sequence motif