Differences between children and adults in thiopurine methyltransferase activity and metabolite formation during thiopurine therapy: Possible role of concomitant methotrexate

Therapeutic Drug Monitoring

Volumn 24, Issue 3, 2002, Pages 351-358

  Pettersson, Birgitta ^a   Almer, Sven ^a   Albertioni, Freidoun ^a   Söderhäll, Stefan ^a   Peterson, Curt ^a  

^a LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

6 mercaptopurine; Azathioprine; Polymorphism; Thiopurine methyltransferase (TPMT); Thiopurine nucleotides

Indexed keywords

AMINOTRANSFERASE; AMYLASE; AZATHIOPRINE; DNA; DRUG METABOLITE; MERCAPTOPURINE; METHOTREXATE; NUCLEOTIDE; THIOPURINE METHYLTRANSFERASE; TIOGUANINE; 6 METHYLTHIOPURINE RIBONUCLEOSIDE 5' PHOSPHATE; 6-METHYLTHIOPURINE RIBONUCLEOSIDE-5'-PHOSPHATE; ANTINEOPLASTIC ANTIMETABOLITE; DRUG DERIVATIVE; IMMUNOSUPPRESSIVE AGENT; MERCAPTOPURINE RIBOSIDE; METHYLTRANSFERASE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; ARTICLE; CHILD; CONTROLLED STUDY; CYTOTOXICITY; DRUG METABOLISM; ENTERITIS; ENZYME ACTIVITY; ENZYME POLYMORPHISM; GASTROINTESTINAL SYMPTOM; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALAISE; METHYLATION; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ACUTE LYMPHOCYTIC LEUKEMIA; AGE; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DRUG COMBINATION; ENZYMOLOGY; ERYTHROCYTE; FEMALE; GENETIC POLYMORPHISM; GENETICS; MALE; METABOLISM;

6-MERCAPTOPURINE; ADULT; AGE FACTORS; ANTIMETABOLITES, ANTINEOPLASTIC; AZATHIOPRINE; CHILD; DRUG THERAPY, COMBINATION; ERYTHROCYTES; FEMALE; HUMAN; IMMUNOSUPPRESSIVE AGENTS; INFLAMMATORY BOWEL DISEASES; LEUKEMIA, LYMPHOCYTIC, ACUTE; MALE; METHOTREXATE; METHYLTRANSFERASES; POLYMORPHISM (GENETICS); SUPPORT, NON-U.S. GOV'T; THIOINOSINE; THIONUCLEOTIDES; HUMANS; POLYMORPHISM, GENETIC;

EID: 0036001231     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-200206000-00005     Document Type: Article

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