메뉴 건너뛰기




Volumn 41, Issue 10, 1998, Pages 1858-1866

Reduced thiopurine methyltransferase activity and development of side effects of azathioprine treatment in patients with rheumatoid arthritis

Author keywords

[No Author keywords available]

Indexed keywords

5' NUCLEOTIDASE; AZATHIOPRINE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; PURINE NUCLEOSIDE PHOSPHORYLASE; THIOPURINE METHYLTRANSFERASE;

EID: 0031715622     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(199810)41:10<1858::AID-ART19>3.0.CO;2-8     Document Type: Article
Times cited : (107)

References (40)
  • 1
    • 0022361042 scopus 로고
    • Cellular pharmacokinetics of mercaptopurine in human neoplastic cells and cell lines
    • Zimm S, Johnson GE, Chabner BA, Poplack DG. Cellular pharmacokinetics of mercaptopurine in human neoplastic cells and cell lines. Cancer Res 1985;45:4156-61.
    • (1985) Cancer Res , vol.45 , pp. 4156-4161
    • Zimm, S.1    Johnson, G.E.2    Chabner, B.A.3    Poplack, D.G.4
  • 2
    • 0016053706 scopus 로고
    • A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine
    • Tidd DM, Paterson AR. A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine. Cancer Res 1974;34:738-46.
    • (1974) Cancer Res , vol.34 , pp. 738-746
    • Tidd, D.M.1    Paterson, A.R.2
  • 3
    • 0000389279 scopus 로고
    • The purine path to chemotherapy
    • Elion GB. The purine path to chemotherapy. Science 1989;24: 441-7.
    • (1989) Science , vol.24 , pp. 441-447
    • Elion, G.B.1
  • 4
    • 0015234301 scopus 로고
    • Further experience with azathioprine in rheumatoid arthritis
    • Harris J, Jessop JD, Chaput de Saintonge DM. Further experience with azathioprine in rheumatoid arthritis. BMJ 1971;4:463-4.
    • (1971) BMJ , vol.4 , pp. 463-464
    • Harris, J.1    Jessop, J.D.2    Chaput De Saintonge, D.M.3
  • 6
    • 0023215564 scopus 로고
    • Low-dose methotrexate compared with azathioprine in the treatment of rheumatoid arthritis: A twenty-four-week controlled clinical trial
    • Hamdy H, McKendry RJR, Mierins E, Liver JA. Low-dose methotrexate compared with azathioprine in the treatment of rheumatoid arthritis: a twenty-four-week controlled clinical trial. Arthritis Rheum 1987;30:361-8.
    • (1987) Arthritis Rheum , vol.30 , pp. 361-368
    • Hamdy, H.1    McKendry, R.J.R.2    Mierins, E.3    Liver, J.A.4
  • 7
    • 0020083379 scopus 로고
    • Rheumatoid arthritis: Treatment with azathioprine (IMURAN®): Clinical side-effects and laboratory abnormalities
    • Whisnant JK, Pelkey J. Rheumatoid arthritis: treatment with azathioprine (IMURAN®): clinical side-effects and laboratory abnormalities. Ann Rheum Dis 1982;41 Suppl 1:44-7.
    • (1982) Ann Rheum Dis , vol.41 , Issue.1 SUPPL. , pp. 44-47
    • Whisnant, J.K.1    Pelkey, J.2
  • 8
    • 0018859828 scopus 로고
    • Disease-modifying drugs for progressive rheumatoid arthritis
    • Bunch TW, O'Duffy JD. Disease-modifying drugs for progressive rheumatoid arthritis. Mayo Clin Proc 1980;55:161-79.
    • (1980) Mayo Clin Proc , vol.55 , pp. 161-179
    • Bunch, T.W.1    O'Duffy, J.D.2
  • 12
    • 0028793746 scopus 로고
    • Azathioprine hypersensitivity-like reactions - A case report and a review of the literature
    • Knowles SR, Gupta AK, Shear NH, Sauder D. Azathioprine hypersensitivity-like reactions - a case report and a review of the literature. Clin Exp Dermatol 1995;20:353-6.
    • (1995) Clin Exp Dermatol , vol.20 , pp. 353-356
    • Knowles, S.R.1    Gupta, A.K.2    Shear, N.H.3    Sauder, D.4
  • 13
    • 0001014921 scopus 로고
    • The effects of azathioprine (Imuran) on purine synthesis in clinical disorders of purine metabolism
    • Kelley WN, Rosenbloom FM, Seegmiller JE. The effects of azathioprine (Imuran) on purine synthesis in clinical disorders of purine metabolism. J Clin Invest 1967;46:1518-29.
    • (1967) J Clin Invest , vol.46 , pp. 1518-1529
    • Kelley, W.N.1    Rosenbloom, F.M.2    Seegmiller, J.E.3
  • 14
    • 0023119219 scopus 로고
    • Thiopurine pharmacogenetics in leukemia: Correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations
    • Lennard L, van Loon JA, Lilleyman JS, Weinshilboum RM. Thiopurine pharmacogenetics in leukemia: correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations. Clin Pharmacol Ther 1987;41:18-25.
    • (1987) Clin Pharmacol Ther , vol.41 , pp. 18-25
    • Lennard, L.1    Van Loon, J.A.2    Lilleyman, J.S.3    Weinshilboum, R.M.4
  • 15
    • 0026717661 scopus 로고
    • The importance of thiopurine methyltransferase activity for the use of azathioprine in transplant recipients
    • Chocair PR, Duley JA, Simmonds HA, Cameron JS. The importance of thiopurine methyltransferase activity for the use of azathioprine in transplant recipients. Transplantation 1992;53: 1051-6.
    • (1992) Transplantation , vol.53 , pp. 1051-1056
    • Chocair, P.R.1    Duley, J.A.2    Simmonds, H.A.3    Cameron, J.S.4
  • 17
    • 0029807388 scopus 로고    scopus 로고
    • Purine enzyme activities in recent onset rheumatoid arthritis: Are there differences between patients and healthy controls?
    • Stolk JN, Boerbooms AMT, De Abreu RA, Kerstens PJSM, de Koning DGM, de Graaf R, et al. Purine enzyme activities in recent onset rheumatoid arthritis: are there differences between patients and healthy controls? Ann Rheum Dis 1996;55:733-8.
    • (1996) Ann Rheum Dis , vol.55 , pp. 733-738
    • Stolk, J.N.1    Boerbooms, A.M.T.2    De Abreu, R.A.3    Kerstens, P.J.S.M.4    De Koning, D.G.M.5    De Graaf, R.6
  • 18
    • 0028068390 scopus 로고
    • Purine enzymes in rheumatoid arthritis: Possible association with response to azathioprine: A pilot study
    • Kerstens PJ, Stolk JN, Boerbooms AM, Lambooy LH, de Graaf R, De Abreu RA, et al. Purine enzymes in rheumatoid arthritis: possible association with response to azathioprine: a pilot study. Ann Rheum Dis 1994;53:608-11.
    • (1994) Ann Rheum Dis , vol.53 , pp. 608-611
    • Kerstens, P.J.1    Stolk, J.N.2    Boerbooms, A.M.3    Lambooy, L.H.4    De Graaf, R.5    De Abreu, R.A.6
  • 19
    • 0025195805 scopus 로고
    • Diurnal variation in the pharmacokinetics and myelotoxicity of mercaptopurine in children with acute lymphocytic leukemia
    • Koren G, Langevin AM, Olivieri N, Giesbrecht E, Zipursky A, Greenberg M. Diurnal variation in the pharmacokinetics and myelotoxicity of mercaptopurine in children with acute lymphocytic leukemia. Am J Dis Child 1990;144:1135-7.
    • (1990) Am J Dis Child , vol.144 , pp. 1135-1137
    • Koren, G.1    Langevin, A.M.2    Olivieri, N.3    Giesbrecht, E.4    Zipursky, A.5    Greenberg, M.6
  • 20
    • 0023945481 scopus 로고
    • The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis
    • Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
    • (1988) Arthritis Rheum , vol.31 , pp. 315-324
    • Arnett, F.C.1    Edworthy, S.M.2    Bloch, D.A.3    McShane, D.J.4    Fries, J.F.5    Cooper, N.S.6
  • 21
  • 22
    • 0026629688 scopus 로고
    • The American College of Rheumatology 1991 revised criteria for the classification of global functional status in rheumatoid arthritis
    • Hochberg MC, Chang RW, Dwosh I, Lindsey S, Pincus T, Wolfe F. The American College of Rheumatology 1991 revised criteria for the classification of global functional status in rheumatoid arthritis. Arthritis Rheum 1992;35:498-502.
    • (1992) Arthritis Rheum , vol.35 , pp. 498-502
    • Hochberg, M.C.1    Chang, R.W.2    Dwosh, I.3    Lindsey, S.4    Pincus, T.5    Wolfe, F.6
  • 23
    • 0014305869 scopus 로고
    • Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis
    • Ritchie DM, Boyle JA, McInnes JM, Jasani MK, Dalakos TG, Grieveson P, et al. Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis. QJM 1968;37:397-406.
    • (1968) QJM , vol.37 , pp. 397-406
    • Ritchie, D.M.1    Boyle, J.A.2    McInnes, J.M.3    Jasani, M.K.4    Dalakos, T.G.5    Grieveson, P.6
  • 25
    • 0028950941 scopus 로고
    • Purine enzyme activities in peripheral blood mononuclear cells: Comparison of a new non-radiochemical high-performance liquid chromatography procedure and a radiochemical thin-layer chromatography procedure
    • Stolk JN, De Abreu RA, Boerbooms AMT, de Koning DGM, de Graaf R, Kerstens PJSM, et al. Purine enzyme activities in peripheral blood mononuclear cells: comparison of a new non-radiochemical high-performance liquid chromatography procedure and a radiochemical thin-layer chromatography procedure. J Chromatogr B Biomed Sci Appl 1995;666:33-43.
    • (1995) J Chromatogr B Biomed Sci Appl , vol.666 , pp. 33-43
    • Stolk, J.N.1    De Abreu, R.A.2    Boerbooms, A.M.T.3    De Koning, D.G.M.4    De Graaf, R.5    Kerstens, P.J.S.M.6
  • 26
    • 0017880983 scopus 로고
    • Human erythrocyte thiopurine methyltransferase: Radiochemical micro assay and biochemical properties
    • Weinshilboum RM, Raymond FA, Pazmino PA. Human erythrocyte thiopurine methyltransferase: radiochemical micro assay and biochemical properties. Clin Chim Acta 1978;85:323-33.
    • (1978) Clin Chim Acta , vol.85 , pp. 323-333
    • Weinshilboum, R.M.1    Raymond, F.A.2    Pazmino, P.A.3
  • 27
    • 0018822866 scopus 로고
    • Mercaptopurine pharmacogenetics: Monogenetic inheritance of erythrocyte thiopurine methyltransferase activity
    • Weinshilboum RM, Sladek SL. Mercaptopurine pharmacogenetics: monogenetic inheritance of erythrocyte thiopurine methyltransferase activity. Am J Hum Genet 1980;32:651-62.
    • (1980) Am J Hum Genet , vol.32 , pp. 651-662
    • Weinshilboum, R.M.1    Sladek, S.L.2
  • 29
    • 0030871031 scopus 로고    scopus 로고
    • Azathioprine-induced severe pancytopenia due to a homozygous two-point mutation of the thiopurine methyltransferase gene in a patient with juvenile HLA-B27-associated spondylarthritis
    • Leipold G, Schütz E, Haas JP, Oellerich M. Azathioprine-induced severe pancytopenia due to a homozygous two-point mutation of the thiopurine methyltransferase gene in a patient with juvenile HLA-B27-associated spondylarthritis. Arthritis Rheum 1997;40: 1896-8.
    • (1997) Arthritis Rheum , vol.40 , pp. 1896-1898
    • Leipold, G.1    Schütz, E.2    Haas, J.P.3    Oellerich, M.4
  • 30
    • 0025331198 scopus 로고
    • Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukemia
    • Lennard L, Lilleyman JS, van Loon J, Weinshilboum RM. Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukemia. Lancet 1990;336:225-9.
    • (1990) Lancet , vol.336 , pp. 225-229
    • Lennard, L.1    Lilleyman, J.S.2    Van Loon, J.3    Weinshilboum, R.M.4
  • 34
    • 0027401302 scopus 로고
    • Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient
    • Schutz E, Gummert J, Mohr F, Oellerich M. Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient [letter]. Lancet 1993;341:436.
    • (1993) Lancet , vol.341 , pp. 436
    • Schutz, E.1    Gummert, J.2    Mohr, F.3    Oellerich, M.4
  • 35
    • 0027173780 scopus 로고
    • Thiopurine-methyl-transferase activity to assess azathioprine myelotoxicity in renal transplant recipients
    • Soria-Royer C, Legendre C, Mircheva J, Premel S, Beaune P, Kreis H. Thiopurine-methyl-transferase activity to assess azathioprine myelotoxicity in renal transplant recipients [letter]. Lancet 1993;341:1593-4.
    • (1993) Lancet , vol.341 , pp. 1593-1594
    • Soria-Royer, C.1    Legendre, C.2    Mircheva, J.3    Premel, S.4    Beaune, P.5    Kreis, H.6
  • 36
    • 0024451147 scopus 로고
    • Pharmacogenetics of acute azathioprine toxicity: Relationship to thiopurine methyltransferase genetic polymorphism
    • Lennard L, van Loon J, Weinshilboum RM. Pharmacogenetics of acute azathioprine toxicity: relationship to thiopurine methyltransferase genetic polymorphism. Clin Pharmacol Ther 1989;46:149-54.
    • (1989) Clin Pharmacol Ther , vol.46 , pp. 149-154
    • Lennard, L.1    Van Loon, J.2    Weinshilboum, R.M.3
  • 37
    • 0023202469 scopus 로고
    • Are children with lymphoblastic leukemia given enough 6-mercaptopurine?
    • Lennard L, Lilleyman JS. Are children with lymphoblastic leukemia given enough 6-mercaptopurine? Lancet 1987;2:785-7.
    • (1987) Lancet , vol.2 , pp. 785-787
    • Lennard, L.1    Lilleyman, J.S.2
  • 38
    • 0030934850 scopus 로고    scopus 로고
    • Molecular diagnosis of thiopurine S-methyltransferase deficiency: Genetic basis for azathioprine and mercaptopurine intolerance
    • Yates CR, Krynetski EY, Loennechen T, Fessing MY, Tai HL, Pui CH, et al. Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance. Ann Intern Med 1997;126:608-14.
    • (1997) Ann Intern Med , vol.126 , pp. 608-614
    • Yates, C.R.1    Krynetski, E.Y.2    Loennechen, T.3    Fessing, M.Y.4    Tai, H.L.5    Pui, C.H.6
  • 39
    • 0027419990 scopus 로고
    • Large interindividual variability in bioavailability of azathioprine in renal transplant recipients
    • Ohlman S, Lafolie P, Lindholm A, Liliemark J, Tyden G, Peterson C. Large interindividual variability in bioavailability of azathioprine in renal transplant recipients. Clin Transplant 1993;7:65-70.
    • (1993) Clin Transplant , vol.7 , pp. 65-70
    • Ohlman, S.1    Lafolie, P.2    Lindholm, A.3    Liliemark, J.4    Tyden, G.5    Peterson, C.6
  • 40
    • 0022551875 scopus 로고
    • Oral 6-mercaptopurine in childhood leukemia: Parent drug pharmacokinetics and active metabolite concentrations
    • Lennard L, Keen D, Lilleyman JS. Oral 6-mercaptopurine in childhood leukemia: parent drug pharmacokinetics and active metabolite concentrations. Clin Pharmacol Ther 1986;40:287-92.
    • (1986) Clin Pharmacol Ther , vol.40 , pp. 287-292
    • Lennard, L.1    Keen, D.2    Lilleyman, J.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.