Inhibition of virus-encoded thymidine kinase suppresses herpes simplex virus replication in vitro and in vivo

Antiviral Chemistry and Chemotherapy

Volumn 9, Issue 1, 1998, Pages 9-18

  Watkins, A M ^a   Dunford, P J ^a   Moffatt, A M ^a   Wong Kai In, P ^a   Holland, M J ^a   Pole, D S ^a   Thomas, G M ^a   Martin, J ^a   Roberts, N A ^a   Mulqueen, M J ^a  

^a Roche Discovery Welwyn ^*  (United Kingdom)

Author keywords

Animal model; Herpes simplex virus; Inhibitor; Ro 32 2313; Ro 32 4397; Thymidine kinase

Indexed keywords

ACICLOVIR; ENZYME INHIBITOR; PRODRUG; RO 322313; RO 324397; THYMIDINE; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DORSAL ROOT; ENZYME INHIBITION; FEMALE; HERPES; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; IN VITRO STUDY; LATENT VIRUS INFECTION; MOUSE; NONHUMAN; PATHOGENICITY; PRIORITY JOURNAL; VIRUS INHIBITION; VIRUS PATHOGENESIS; VIRUS REPLICATION;

ANIMALS; ANTIVIRAL AGENTS; CERCOPITHECUS AETHIOPS; CRICETINAE; ENZYME INHIBITORS; FEMALE; GANGLIA; HERPESVIRUS 1, HUMAN; HERPESVIRUS 2, HUMAN; MICE; MICE, INBRED BALB C; THYMIDINE; THYMIDINE KINASE; VERO CELLS; VIRUS LATENCY; VIRUS REPLICATION;

EID: 0031964304     PISSN: 09563202     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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