Reductions in membrane proteins and lipids in basal ganglia of classic Alzheimer disease patients

Alzheimer Disease and Associated Disorders

Volumn 10, Issue 2, 1996, Pages 77-81

  Gottfries, Carl Gerhard ^a   Jungbjer, Birgitta ^a   Karlsson, Ingvar ^a   Svennerholm, Lars ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Alzheimer disease; Gangliosides

Indexed keywords

GANGLIOSIDE; MEMBRANE LIPID; MEMBRANE PROTEIN; PHOSPHOLIPID;

AGED; ALZHEIMER DISEASE; ARTICLE; BASAL GANGLION; CAUDATE NUCLEUS; CONTROLLED STUDY; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; MOTOR PERFORMANCE; NEOSTRIATUM; PRIORITY JOURNAL; PUTAMEN;

ADULT; AGED; ALZHEIMER DISEASE; BASAL GANGLIA; CAUDATE NUCLEUS; FEMALE; HIPPOCAMPUS; HUMANS; MALE; MEMBRANE LIPIDS; MEMBRANE PROTEINS; MIDDLE AGED; PUTAMEN;

EID: 0029979095     PISSN: 08930341     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002093-199601020-00004     Document Type: Article

References (18)

1. Adolfsson R, Gottfries CG, Nyström L, Winblad B. Prevalence of dementia disorders in institutionalized Swedish old people. The work load imposed by caring for these patients. Acta Psychiatr Scand 1981;63:225-44.
2. Blennow K, Wallin A. Clinical heterogeneity of probable Alzheimer's disease. J Geriatr Psychiatry Neurol 1992;5:106-13.
3. Blennow K, Wallin A, Gottfries CG. Presence of parieto-temporal symptomatology distinguishes early- and late-onset Alzheimer's disease. Int J Geriatr Psychiatry 1991;6:147-54.
4. Carlsson A. Aging and brain neurotransmitters. In: Crook Th, Gershon S, eds. Strategies for the development of an effective treatment for senile dementia. New Canaan: Mark Powley, 1981:93-106.
5. Cohen G. Historical views and evolution of concepts. In: Reisberg B, ed. Alzheimer's disease. New York: Free Press, 1983:29-33.
6. Gottfries CG, Blennow K, Regland B, Wallin A. Alzheimer's disease - one, two or several? In: Maurer K, Riederer P, Beckmann H, eds. Alzheimer's disease. Epidemiology, neuropathology, neurochemistry and clinics. New York: Springer-Verlag, 1990:343-56.
7. Gottfries CG, Gottfries I, Roos BE. The investigation of homovanillic acid in the human brain and its correlation to senile dementia. Br J Psychiatry 1969;115:563-74.
8. Katzman R. Alzheimer's disease. N Engl J Med 1986;314:964-73.
9. Kraepelin E. Senile and pre-senile dementias. Leipzig: Johann Ambrosius Barth, 1910:533-54,593-632.
10. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-44.
11. Miller-Podraza H, Måsson J-E, Svennerholm L. Isolation of complex gangliosides from human brain. Biochim Biophys Acta 1992;1124:45-51.
12. 3H]imipramine binding in aged human brain. J Neurochem 1985;45:1382-9.
13. Sjögren H. Twenty-four cases of Alzheimer's disease. Acta Med Scand [Suppl] 1950;245:225-33.
14. Sjögren T, Sjögren H, Lindgren Å. Morbus Alzheimer and morbus Pick: a genetic, clinical and patho-anatomical study. Acta Psychiatr Neurol Scand [Suppl] 1952;82:66-115.
15. Svennerholm L. Quantitative estimation of gangliosides in senile human brain. Acta Soc Med Upsal 1957;62:1-16.
16. Svennerholm L, Broström K, Helander CG, Jungbjer B. Membrane lipids in the aging human brain. J Neurochem 1991;56:2051-9.
17. Svennerholm L, Broström K, Jungbjer B, Olsson L. Membrane lipids of adult human brain: lipid composition in frontal and temporal lobe in subjects of age 20 to 100 years. J Neurochem 1994;63:1802-11.
18. Svennerholm L, Gottfries CG. Membrane lipids selectively diminished in Alzheimer brains suggest synapse loss as primary event in early onset form (Type I) and demyelination in late onset from (Type II). J Neurochem 1994;62:1039-47.