Induction of immunologic tolerance for allogeneic hematopoietic cell transplantation

Leukemia and Lymphoma

Volumn 43, Issue 6, 2002, Pages 1159-1167

  Appleman, Leonard J ^a   Tzachanis, Dimitrios ^a   Grader Beck, Thomas ^a   Van Puijenbroek, Andre A F L ^a   Boussiotis, Vassiliki A ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Allogeneic hematopoietic cell transplantation; Chemotherapy; Immunologic tolerance; Immunosuppression

Indexed keywords

ALLOANTIGEN; HLA ANTIGEN; MYELOABLATIVE AGENT; T LYMPHOCYTE ANTIGEN; T LYMPHOCYTE RECEPTOR; ABATACEPT; ANTIBODY CONJUGATE; B7 ANTIGEN; CD28 ANTIGEN; CD40 ANTIGEN; CD40 LIGAND; CD86 ANTIGEN; CD86 PROTEIN, HUMAN; CD86 PROTEIN, MOUSE; CDKN1B PROTEIN, MOUSE; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1B; LEUKOCYTE ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN; TUMOR SUPPRESSOR PROTEIN;

ALLOTRANSPLANTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; BLOOD DONOR; CANCER CHEMOTHERAPY; CANCER IMMUNOLOGY; CANCER RECURRENCE; CELLULAR IMMUNITY; CLONAL ANERGY; CONTROLLED STUDY; DECISION MAKING; GRAFT VERSUS HOST REACTION; GRAFT VERSUS LEUKEMIA EFFECT; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HLA SYSTEM; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOSUPPRESSIVE TREATMENT; IN VIVO STUDY; LEUKEMIA; MOUSE; NONHUMAN; OPPORTUNISTIC INFECTION; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; ANIMAL; DRUG ANTAGONISM; HISTOCOMPATIBILITY; IMMUNOLOGY; LYMPHOCYTE DEPLETION; METHODOLOGY; PHYSIOLOGY; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, CD40; ANTIGENS, CD80; ANTIGENS, CD86; CD40 LIGAND; CELL CYCLE PROTEINS; CLONAL ANERGY; CYCLIN-DEPENDENT KINASE INHIBITOR P27; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HISTOCOMPATIBILITY; HUMANS; IMMUNOCONJUGATES; IMMUNOSUPPRESSION; LYMPHOCYTE DEPLETION; MEMBRANE GLYCOPROTEINS; MICE; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES; TRANSPLANTATION, HOMOLOGOUS; TUMOR SUPPRESSOR PROTEINS;

EID: 0035992249     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.1080/10428190290026213     Document Type: Review

References (73)

1. "Haematopoietic cell transplantation as immunotherapy"
2. "Treatment of murine leukemia with X-rays and homologous bone marrow. Preliminary communication"
3. "Antileukemic effects of graft-versus-host disease in human recipients of allogeneic marrow grafts"
4. "Antileukemic effect of chronic graft-versus-host disease. Contribution to improved survival after allogeneic marrow transplantation"
5. "Graft-versus-leukemia reactions after bone marrow transplantation"
6. "Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. European group for blood and marrow transplantation working party chronic leukemia"
7. "Interaction between CD4 and class II MHC molecule mediates cell adhesion"
8. "Cell-cell adhesion mediated by CD8 and MHC class I molecules"
9. "Nomenclature for factors of the HLA system, 1998"
10. "Deconstructing the MHC"
11. "Mechanisms of disease. Graft-versus-host disease"
12. "Acute graft-versus-host disease: Analysis of risk factors after allogeneic marrow transplantation and prophylaxis with cyclosporin and methotrexate"
13. "Optimizing outcome after unrelated marrow transplantation by comprehensive matching of HLA class I and II alleles in the donor and recipient"
14. "Association of HLA-C display with graft failure after marrow transplantation form unrelated donors"
15. "T cell-depleted allogeneic bone marrow transplantation as postremission therapy for acute myelogenous leukemia: Freedom from relapse in the absence of graft-versus host disease"
16. "T cell reconstitution after stem-cell transplantation-by which organ?"
17. "Effect of low-dose interleukin-2 on disease relapse after T cell depleted allogeneic bone marrow transplantation"
18. "Comparison of single-dose and escalating dose regimens of donor lymphocyte infusion for relapse after allografting for chronic myeloid leukemia"
19. "Blockade of the CD28 costimulatory pathway: A means to induce tolerance"
20. "T cell clonal anergy"
21. "Recent advances in graft-versus-host disease prevention"
22. "The role of B7-1/B7-2:CD28/CTLA-4 pathways in the prevention of anergy, induction of productive immunity and down-regulation of the immune response"
23. "The role of the T cell costimulator B7-1 in autoimmunity and the induction and maintenance of tolerance to peripheral antigen"
24. "T cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo"
25. "Prevention of chronic rejection in mouse aortic allografts by combined treatment with CTLA4-Ig and anti-CD40 ligand monoclonal antibody"
26. "CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates"
27. "In vivo blockade of CD28/CTLA4:B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice"
28. "Treatment of murine lupus with CTLA4Ig"
29. "Blockade of CD40 ligand-CD40 interaction impairs CD4+ T cell-mediated alloreactivity by inhibiting mature donor T cell expansion and function after bone marrow transplantation"
30. "Induction of alloantigen-specific tolerance by B cells from CD40-deficient mice"
31. "Positive and negative signaling by lymphocyte receptors"
32. "Helper T cell anergy: From biochemistry to cancer pathophysiology and therapeutics"
33. "T cell receptor signalling"
34. "Blocked signal transduction to the ERK and JNK protein kinases in anergic CD4+ T cells"
35. " ζ phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists"
36. "Partial T cell signaling: Altered phospho-ζ and lack of Zap70 recruitment in APL-induced T cell anergy"
37. "Differential association of protein tyrosine kinases with T cell receptor is linked to the induction of anergy and its prevention by B7 family-mediated costimulation"
38. "Anergic T-lymphocyte clones have altered inositol phosphate, calcium and tyrosine kinase signaling pathways"
39. "Maintenance of human T cell anergy: Blocking of IL-2 gene transcription by activated Rap1"
40. "Tob is a negative regulator of activation expressed in anergic and quiescent T cells"
41. "The role of cell division in the induction of clonal anergy"
42. "Reversal of in vitro T cell clonal anergy by IL-2 stimulation"
43. "Prevention of T cell anergy by signaling through the γc chain of the IL-2 receptor"
44. kip1 functions as an anergy factor inhibiting IL-2 transcription and clonal expansion of alloreactive human and murine helper T lymphocytes"
45. kip1 on resistance of tumor cells to anticancer agents"
46. kip1 protein: Prognostic implications in primary breast cancer"
47. kip1 in non-small cell lung carcinoma: A prognostic factor independent of Ras. Nat. Med. 1999"
48. "Role of ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27"
49. kip1"
50. kip1"
51. "Regulation of the cyclin-dependent kinase inhibitor p27 by degradation and phosphorylation"
52. kip1, polyploidy and centrosome overduplication"
53. Skp2-mediated ubiquitination of p27"
54. "CD4+ T cells tolerized ex vivo to host alloantigen by anti-CD40 ligand (CD40L: CD154) antibody lose their graft-versus-host lethality capacity but retain normal antigen responses"
55. "Complete blockade of B7 family mediated costimulation is necessary to induce alloantigen specific anergy: A method to ameliorate graft versus host disease and extend the donor pool"
56. "Transplantation of anergic histoincompatible bone marrow allografts"
57. "Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells"
58. "A CD4+ T cell subset inhibits antigen-specific T cell responses and prevents colitis"
59. "Direct effects of IL-10 on subsets of human CD4+ T cell clones and resting T cells. Specific inhibition of IL-2 production and proliferation"
60. "Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation via down-regulation of class II major histocompatibility complex"
61. "Shevach E.M. IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression"
62. "Inhibition of Langerhans cell antigen-presenting function by IL-10. A role of IL-10 in induction of tolerance"
63. "High levels of IL-10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells"
64. "Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease"
65. "Abrogation of TGFb signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease"
66. "Induction of CD4+ T cell alloantigen-specific hyporesponsiveness by IL-10 and TGF-β"
67. "Altered T cell receptor + CD28-mediated signaling and blocked cell cycle progression in interleukin 10 and transforming growth factor-b-treated alloreactive T cells that do not induce graft-versus-host disease"
68. "Cytokine cascades in acute graft-versus-host disease"
69. "Prevention of graft versus host disease by inactivation of host antigen-presenting cells"
70. "Blockade of B7/CD28 pathway in MLR cultures results in the generation of alternatively activated macrophages, which suppress T cell responses"
71. "Cell cycle and biochemical effects of PD 0183812"
72. "Combined costimulation blockade plus rapamycin but not cyclosporin produces permanent engraftment"
73. "Prolonged survival without post-transplant immunosuppression in a large animal model"