Complete blockade of B7 family-mediated costimulation is necessary to induce human alloantigen-specific anergy: A method to ameliorate graft-versus-host disease and extend the donor pool

Blood

Volumn 87, Issue 11, 1996, Pages 4887-4893

  Gribben, John G ^a   Guinan, Eva C ^b   Boussiotis, Vassiliki A ^b   Ke, Xiao Yan ^b   Linsley, Letitia ^b   Sieff, Colin ^b   Gray, Gary S ^b   Freeman, Gordon J ^b   Nadler, Lee M ^b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADOPTIVE TRANSFER; ANTIGEN SPECIFICITY; ARTICLE; BLOOD DONOR; BONE MARROW TRANSPLANTATION; CELL PROLIFERATION; CELL STIMULATION; CLONAL ANERGY; GENE INDUCTION; GRAFT VERSUS HOST REACTION; HUMAN; HUMAN CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; MIXED LYMPHOCYTE REACTION; PRIORITY JOURNAL; T LYMPHOCYTE;

ANTIGEN PRESENTATION; ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, CD80; ANTIGENS, CD86; ANTIGENS, DIFFERENTIATION; CELLS, CULTURED; CLONAL ANERGY; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELLS; HUMANS; IMMUNOCONJUGATES; INTERLEUKIN-2; INTERLEUKIN-4; ISOANTIGENS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE TEST, MIXED; MEMBRANE GLYCOPROTEINS; RNA, MESSENGER; T-LYMPHOCYTES, CYTOTOXIC; TISSUE AND ORGAN PROCUREMENT; TISSUE DONORS;

EID: 0029945316     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.11.4887.bloodjournal87114887     Document Type: Article

References (35)

1. Beatty PG, Clift RA, Mickelson EM, Nisperos BB, Flournoy N, Martin PJ, Sanders JE, Stewart P, Buckner CD, Storb R, Thomas ED, Hansen JA: Marrow transplantation from related donors other than HLA-identical siblings. N Engl J Med 313:765, 1985
2. Kernan NA, Bartsch G, Ash RC, Beatty PG, Champlin R, Filipovich A, Gajewski J, Hansen JA, Henslee-Downey J, McCullough J, McGlave P, Perkins HA, Phillips GL, Sanders J, Stroncek D, Thomas ED, Blume KG: Analysis of 462 transplantations from unrelated donors facilitated by the National Marrow Donor Program. N Engl J Med 328:593, 1993
3. McGlave P, Bartch G, Anasetti C, Ash R, Beatty P, Gajewski J, Kernan NA: Unrelated donor marrow transplantation therapy for chronic myelogenous leukemia: Initial experience of the National Marrow Donor Program. Blood 81:543, 1993
4. Davies SM, Shu XO, Blazar BR, Filipovich AH, Kersey JH, Krivit W, McCullough J, Miller WJ, Ramsay NKC, Segall M, Wagner JE, Weisdorf DJ, McGlave PB: Unrelated donor blood marrow transplantation: Influence of HLA A and B incompatibility on outcome. Blood 86:1636, 1995
5. Petersdorf EW, Longton GM, Anasetti C, Martin PJ, Mickelson EM, Smith AG, Hansen JA: The significance of HLA-DRB1 matching on clinical outcome after HLA-A, B, DR identical unrelated donor marrow transplantation. Blood 86:1606, 1995
6. Ferrara JLM, Deeg HJ: Mechanisms of disease. Graft-versus-host disease. N Engl J Med 324:667, 1991
7. Theobald M, Nierle T, Bunjes D, Arnold R, Heimpel H: Host-specific interleukin-2-secreting donor T-cell precursors as predictors of acute graft-versus-host disease in bone marrow transplantation between HLA-identical siblings, N Engl J Med 327:1613, 1992
8. Schwarer AP, Jiang YZ, Brookes PA, Barren AJ, Batchelor JR, Goldman JM, Lechler RI: Frequency of anti-recipient alloreactive helper T-cell precursors in donor blood and graft-versus-host disease after HLA-identical sibling bone-marrow transplantation. Lancet 341:203, 1993
9. Pirsch JD, Maki DG: Infectious complications in adults with bone marrow transplantation and T-cell depletion of donor marrow: Increased susceptibility to fungal infections. Ann Intern Med 104:619, 1986
10. Goldman JM, Gale RP, Horowitz MM, Biggs JC, Champlin RE, Gluckman E, Hoffman RG, Jacobsen SJ, Marmont AM, McGlave PB, Messner HA, Rimm AA, Rozman C, Speck B, Tura S, Weiner RS, Bortin MM: Bone marrow transplantation for chronic myelogenous leukemia in chronic phase: Increased risk for relapse associated with T-cell depletion. Ann Intern Med 108:806, 1988
11. Storb R, Deeg HJ, Pepe M, Appelbaum F, Anasetti C, Beatty P, Bensinger W, Berenson R, Buckner CD, Clift R, Doney K, Longton G, Hansen J, Hill R, Loughran TJ, Martin P, Singer J, Sanders J, Stewart P, Sullivan K, Witherspoon R, Thomas ED: Methotrexate and cyclosporine versus cyclosporine alone for prophylaxis of graft-versus-host disease in patients given HLA-identical marrow grafts for leukemia: Long-term follow-up of a controlled trial. Blood 73:1729, 1989
12. Marmont AM, Horowitz MM, Gale RP, Sobocinski K, Ash RC, van Bekkum DW, Champlin RE, Dicke KA, Goldman JM, Good RA, Herzig RH, Hong R, Masaoka T, Rimm AA, Ringden O, Speck B, Weiner RS, Bortin MM: T-cell depletion of HLA-identical transplants in leukemia. Blood 78:2120, 1991
13. d'Amore ESG, Manivel JC, Gajl-Peczalska KJ, Litz CE, Copenhaver CM, Shapiro RS, Strickler JG: B-cell lymphoproliferative disorders after bone marrow transplantation. Cancer 68:1285, 1991
14. Young JW, Papadopoulos EB, Cunningham I, Castro MH, Flomenberg N, Carabasi MH, Gulati SC, Brochstein JA, Heller G, Black P, Collins NH, Shank B, Kernan NA, O'Reilly RJ: T-cell-depleted allogeneic bone marrow transplantation in adults with acute nonlymphocytic leukemia in first remission. Blood 79:3380, 1992
15. Ringden O, Horowitz MM, Sondel P, Gale RP, Biggs JC, Champlin RE, Deeg HJ, Dicke K, Masaoka T, Powles RL, Rimm AA, Rozman C, Sobocinski KA, Speck B, Zwaan FE, Bortin MM: Methotrexate, cyclosporine, or both to prevent graft-versus-host disease after HLA-identical sibling bone marrow transplants for early leukemia? Blood 81:1094, 1993
16. Linsley PS, Brady W, Grosmaire L, Aruffo A, Damle NK, Ledbetter JA: Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J Exp Med 173:721, 1991
17. Harding FA, McArthur JG, Gross JA, Raulet DH, Allison JP: CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 356:607, 1992
18. Gimmi CD, Freeman GJ, Gribben JG, Sugita K, Freedman AS, Morimoto C, Nadler LM: B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2. Proc Natl Acad Sci USA 88:6575, 1991
19. Freeman GJ, Gribben JG, Boussiotis VA, Ng JW, Restivo VAJ, Lombard LA, Gray GS, Nadler LM: Cloning of B7-2: A CTLA-4 counter-receptor that costimulates human T cell proliferation. Science 262:909, 1993
20. Cerdan C, Martin Y, Courcoul M, Brailly H, Mawas C, Birg F, Olive D: Prolonged IL-2 receptor alpha/CD25 expression after T cell activation via the adhesion molecules CD2 and CD28. Demonstration of combined transcriptional and post-transcriptional regulation. J Immunol 149:2255, 1992
21. Cerdan C, Martin Y, Courcoul M, Mawas C, Birg F, Olive D: CD28 costimulation upregulates long-term IL-2Rβ expression in human T cells through combined transcriptional and post-transcriptional regulation. J Immunol 154:1007, 1995
22. Freeman GJ, Boussiotis VA, Anumanthan A, Bernstein GM, Ke X-Y, Rennen PD, Gray GS, Gribben JG, Nadler LM: B7-1 and B7-2 do not deliver identical costimulatory signals since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4. Immunity 2:523, 1995
23. Linsley PS, Brady W, Urnes M, Grosmaire LS, Damle NK, Ledbetter JA: CTLA-4 is a second receptor for the B cell activation antigen B7. J Exp Med 174:561, 1991
24. Gimmi CD, Freeman GJ, Gribben JG, Gray G, Nadler LM: Human T -cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation. Proc Natl Acad Sci USA 90:6586, 1993
25. Tan P, Anasetti C, Hansen JA, Melrose J, Brunvand M, Bradshaw J, Ledbetter JA, Linsley PS: Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1. J Exp Med 177:165, 1993
26. Lin H, Boiling SF, Linsley PS, Wei RQ, Gordon D, Thompson CB, Turka LA: Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4-Ig plus donor-specific transfusion. J Exp Med 178:1801, 1993
27. Lenschow DJ, Zeng Y, Thistlethwaite JR, Montag A, Brady W, Gibson MG, Linsley PS, Bluestone JA: Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA41g. Science 257:789, 1992
28. Blazar BR, Taylor PA, Linsley PS, Vallera DA: In vivo blockade of CD28/CTLA4:By/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice. Blood 83:3815, 1994
29. Taswell C: Limiting dilution assays for the determination of immunocompetent cell frequencies. J Immunol 126:1614, 1981
30. Sutherland HJ, Lansdorp PM, Henkelman DH, Eaves AC, Eaves CJ: Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow. Proc Natl Acad Sci USA 87:3584, 1990
31. Verfaillie C, Blakolmer K, McGlave P: Purified primitive human hematopoietic progenitor cells with long-term in vitro repopulating capacity adhere selectively to irradiated bone marrow stroma. J Exp Med 172:509, 1990
32. Dexter TM, Moore MAS, Sheridan APC: Maintenance of hemopoietic stem cells and production of differentiated progeny in allogeneic and semiallogeneic bone marrow chimeras in vitro. J Exp Med 145:1612, 1977
33. Boussiotis VA, Barber DL, Nakarai T, Freeman GJ, Gribben JG, Bernstein GM, D'Andrea AL, Ritz J, Nadler LM: Prevention of T cell anergy by signaling through the γc chain of the IL-2 receptor. Science 266:1039, 1994
34. Boussiotis VA, Freeman GJ, Griffin JD, Gray GS, Gribben JG, Nadler LM: CD2 is involved in maintenance and reversal of human alloantigen specific clonal anergy. J Exp Med 180:1665, 1994
35. Holler E, Kolb HJ, Mittermuller J, Kaul M, Ledderose G, Duell T, Seeber B, Schleuning M, Hintermeier-Knabe R, Ertl B, Kemeni J, Wilmans W: Modulation of acute graft-versus-host disease after allogeneic bone marrow transplantation by tumor necrosis factor a (TNFα) release in the course of pretransplant conditioning: Role of conditioning regimens and prophylactic applications of a monoclonal antibody neutralizing human TNFa (MAK 195F). Blood 86:890, 1995