In vitro mimicry of essential fatty acid deficiency in human endothelial cells by TNFα impact of ω-3 versus ω-6 fatty acids

Journal of Lipid Research

Volumn 43, Issue 6, 2002, Pages 944-951

  Mayer, Konstantin ^a   Schmidt, Reinhold ^a   Muhly Reinholz, Marion ^a   Bögeholz, Tina ^a   Gokorsch, Stephanie ^a   Grimminger, Friedrich ^a   Seeger, Werner ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Arachidonic acid; Eicosapentaenoic acid; Mead acid; Phosphatidylcholine; Phosphatidylinositol

Indexed keywords

5,8,11 ICOSATRIENOIC ACID; ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLSERINE; PHOSPHOLIPID; POLYUNSATURATED FATTY ACID; TUMOR NECROSIS FACTOR ALPHA; ESSENTIAL FATTY ACID; FATTY ACID; SPHINGOMYELIN;

ARTICLE; ENDOTHELIUM CELL; ESSENTIAL FATTY ACID DEFICIENCY; FATTY ACID TRANSPORT; HUMAN; HUMAN CELL; INFLAMMATION; LIPID COMPOSITION; PRIORITY JOURNAL; SUPPLEMENTATION; TRANSPORT KINETICS; CELL CULTURE; IN VITRO STUDY; KINETICS; METABOLISM; MOLECULAR MIMICRY; VASCULAR ENDOTHELIUM;

CELLS, CULTURED; ENDOTHELIUM, VASCULAR; FATTY ACIDS; FATTY ACIDS, ESSENTIAL; FATTY ACIDS, OMEGA-3; HUMAN; IN VITRO; KINETICS; MOLECULAR MIMICRY; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINES; PHOSPHATIDYLINOSITOLS; PHOSPHATIDYLSERINES; PHOSPHOLIPIDS; SPHINGOMYELINS; SUPPORT, NON-U.S. GOV'T; TUMOR NECROSIS FACTOR; HUMANS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035988348     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Has the mortality of septic shock changed with time?
2. Treating patients with severe sepsis
3. Sepsis: A new hypothesis for pathogenesis of the disease process
4. Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock
5. Reactive oxygen species in acute lung injury
6. Lipid mediators in inflammatory disorders
7. Endothelial cells: Role in infection and inflammation
8. Endothelial activation by cytokines
9. Target effector role of vascular endothelium in the inflammatory response: Insights from the clinical trial of anti-TNFα antibody in rheumatoid arthritis
10. Clinical use of lipids to control inflammatory disease
11. Immunoregulatory and anti-inflammatory effects of n-3 polyunsaturated fatty acids
12. The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells
13. Docosahexaenoic acid selectively attenuates induction of vascular cell adhesion to human endothelial cells stimulated by tumor necrosis factor-α
14. The omega-3 fatty acid docosahexaenoate reduces cytokine-induced expression of proatherogenic and proinflammatory proteins in human endothelial cells
15. Gammalinolenic acid and dihomogammalinolenic acid suppress the CD3-mediated signal transduction pathway in human T cells
16. Polyunsaturated fatty acids and signalling via phospholipase C-b and A2 in myocardium
17. Dietary omega-3 polyunsaturated fatty acids inhibit phosphoinositide formation and chemotaxis in neutrophils
18. Immune and nutritional effects of early enteral nutrition after major abdominal operations
19. A randomized trial of isonitrogenous enteral diets after severe trauma
20. Early postoperative enteral immunonutrition: Clinical outcome and cost-comparison analysis in surgical patients
21. Effects of dietary marine oils and olive oil on fatty acid composition, platelet membrane fluidity, platelet responses, and serum lipids in healthy humans
22. Effects of dietary fish oil and soy phosphatidylcholine on neutrophil fatty acid composition, superoxide release, and adhesion
23. 2 production in a rat model of chronic sepsis
24. Essential fatty acids influence survival in sepsis
25. Parenteral nutrition with n-6 vs. n-3-fatty acid-based lipid emulsions in septic patients - Effects on plasma free fatty acids and lipid mediator generation
26. 2α in the epidermis of psoriasis
27. Permeability and vasomotor response of celebral vessels during exposure to arachidonic acid
28. Platelet-neutrophil interactions
29. Essential fatty acid deficiency and predisposition to lung disease in cystic fibrosis
30. Development and characterization of essential fatty acid deficiency in human endothelial cells in culture
31. Culture of human endothelial cells derived from umbilical veins
32. The listerial exotoxins listeriolysin and phosphatidylinositol-specific phospholipase C synergize to elicit endothelial cell phosphoinositide metabolism
33. A rapid method of total lipid extraction and purification
34. Two dimensional thin layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots
35. Surfactant alterations in severe pneumonia, acute respiratory distress syndrome, and cardiogenic lung edema
36. Densitometric quantification of individual phospholipids. Improvement and evaluation of a method using molybdenum blue reagent for detection
37. A reagent for the non-destructive location of steroids and some other lipophilic materials on silica gel thin-layer chromatograms
38. Influence of long-term n-3 lipid infusion on plasma and membrane fatty acids and lipid mediator generation in a patient with severe ulcerative colitis
39. Alteration of fatty acid profiles in different pulmonary surfactant phospholipids in acute respiratory distress syndrome (ARDS) and severe pneumonia
40. Studies on the formation of dipalmitoyl species of phosphatidylcholine and phosphatidylethanolamine in pulmonary type II cells
41. Separation of alkylacyl and diacyl glycerophospholipids and their molecular species as naphthylurethanes by high-performance liquid chromatography
42. Alteration in the membrane fatty acid composition of human lymphocytes and cultured transformed cells induced by interferon
43. Fatty acid metabolism in human lymphocytes. I. Time-course changes in fatty acid composition and membrane fluidity during blastic transformation of peripheral blood lymphocytes
44. Long-term fatty acid modification of endothelial cells: Implications for arachidonic acid distribution in phospholipid classes
45. Serum cytokine levels in human septic shock
46. 14C]5.8.11-eicosatrienoic (Mead) acid in rat hepatocytes
47. Effect of dietary supplementation with n-9 eicosatrienoic acid on leukotriene B4 synthesis in rats: A novel approach to inhibition of eicosanoid synthesis
48. An in vitro model for essential fatty acid deficiency: HepG2 cells permanently maintained in lipid-free medium
49. Tumor necrosis factor-induced release of endogenous fatty acids analyzed by a highly sensitive high-performance liquid chromatography method
50. Interleukin-1 enhances the ability of cultured human umbilical vein cells to oxidize linoleic acid
51. Linoleic acid potentiates TNF-mediated oxidative stress, disruption of calcium homeostasis, and apoptosis of cultured vascular endothelial cells
52. Linoleic acid and TNF-α cross-amplify oxidative injury and dysfunction of endothelial cells
53. Utilization of arachidonic and linoleic acids by cultured endothelial cells
54. Altered phosphoinositide fatty acid composition, mass and metabolism in brain essential fatty acid deficiency
55. Effects of long-term supplementation of eicosapentaenoic acid and docosahexaenoic acid on the 2-, 3-series prostacyclin production by endothelial cells