Effects of long-term supplementation of eicosapentanoic and docosahexanoic acid on the 2-, 3-series prostacyclin production by endothelial cells

Prostaglandins and Other Lipid Mediators

Volumn 57, Issue 5-6, 1999, Pages 333-340

  Hishinuma, Takanori ^a   Yamazaki, Tohru ^a   Mizugaki, Michinao ^a  

^a TOHOKU UNIVERSITY HOSPITAL   (Japan)

Author keywords

Docosahexaenoic acid; Eicosapentaenoic acid; Gas chromatography mass spectrometry (GC MS); Prostacyclin

Indexed keywords

6 OXOPROSTAGLANDIN F1 ALPHA; ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; PROSTACYCLIN DERIVATIVE; PROSTANOIC ACID DERIVATIVE;

ANIMAL CELL; AORTA; ARTICLE; CATTLE; CELL CULTURE; CONTROLLED STUDY; ENDOTHELIUM CELL; GAS CHROMATOGRAPHY; IN VITRO STUDY; LIPID METABOLISM; MASS SPECTROMETRY; NONHUMAN; PROSTAGLANDIN SYNTHESIS;

ANIMALS; CATTLE; CELLS, CULTURED; DOCOSAHEXAENOIC ACIDS; EICOSAPENTAENOIC ACID; ENDOTHELIUM, VASCULAR; EPOPROSTENOL; GAS CHROMATOGRAPHY-MASS SPECTROMETRY;

EID: 0032839599     PISSN: 00906980     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0090-6980(98)00083-5     Document Type: Article

References (22)

1. Dyerberg J, Bang HO, Stofferson E, Moncada S, Vane JR. Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis. Lancet 1978;II:117-9.
2. Dyerberg J, Bang HO. Haemostatic function and platelet poly-unsaturated fatty acids in Eskimos. Lancet 1979;II:433-5.
3. Dyerberg J., Bang H.O. Lipid metabolism, atherogenesis and haemostasis in Eskimos The role of the prostaglandin n-3 family . Haemostasis. 8:1979;227-233.
4. Moncada S., Gryglewski R., Bunting S., Vane J.R. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature. 263:1976;663-665.
5. 3) is formed in human platelets after dietary eicosapentanoic acid (C 20 5 w 3) . Biochem Biophys Res Commun. 116:1983;1091-1099.
6. Fischer S., Weber P.C., Dyerberg J. The prostacyclin/thromboxane balance is favourably shifted in Greenland Eskimos. Prostaglandins. 32:1986;235-241.
7. 3 levels . Meth Find Exp Clin Pharmacol. 19:1997;429-433.
8. 3 is formed in vivo in man after dietary eicosapentanoic acid. Nature. 307:1984;165-168.
9. Hadjagapiou C., Kaduce T.L., Spector A.A. Eicosapentaenoic acid utilization by bovine aortic endothelial cells Effects on prostacyclin production . Biochim Biophys Acta. 875:1986;369-381.
10. Benistant C., Achard F., Marcelon G., Lagarde M. Platelet inhibitory functions of aortic endothelial cells. Effects of eicosapentanoic and docosahexanoic acids. Atherosclerosis. 104:1993;27-35.
11. Bordet J.C., Guichardent M., Lagarde M. Hydroperoxides produced by n-6 lipoxigenation of arachidonic and linoleic acids potentiate synthesis of prostacyclin related compounds. Biochim Biophys Acta. 958:1987;460-468.
12. Rosenthal M.D., Garcia M.C., Jones M.R., Sprecher H. Retroconversion and D4 desaturation of docosatetraenoate (22:4 (n-6)) and docosapentaenoate (22:5 (n-3)) by human cells in culture. Biochim Biophys Acta. 1083:1991;29-36.
13. Prisco D., Filippini M., Francalanci I., et al. Effect of n-3 polyunsaturated fatty acid intake on phospolipid fatty acid composition in plasma and erythrocytes. Am J Clin Nutr. 63:1996;925-932.
14. Von Schacky C., Fischer S., Weber P.C. Long-term effects of dietary marine w-3 fatty acids upon plasma and cellular lipids, platelet function and eicosanoid formation in humans. J Clin Invest. 76:1985;1626-1631.
15. Saynor R., Verel D., Gillot T. The long-term effect of dietary supplementation with fish lipid concentrate on serum lipids, bleeding time, platelets and angina. Atherosclerosis. 50:1984;3-10.
16. 3. Prostaglandins 1987;34:367-5.
17. Gronn M., Christensen E., Hagve T.A., Christophersen B.O. Peroxisomal retroconversion of docosahexanoic acid (22:6 (n-3)) to eicosapentanoic acid (20:5 (n-3)) studied in isolated rat liver cells. Biochim Biophys Acta. 1081:1991;85-91.
18. Achard F., Benistant C., Lagarde M. Interconversion and distinct metabolic fate of eicosapentaenoic, docosapentaenoic and docosahexanoic acids in bovine aortic endothelial cells. Biochim Biophys Acta. 1255:1995;260-266.
19. Benistant C., Achard F., Ben slama S., Lagarde M. Docosapentaenoic acid (22:5, n-3) metabolism and effect on prostacyclin production in endothelial cells . Prostaglandins Leukot Essent Fatty Acids. 55:1996;287-292.
20. Brouard C., Pascaud M. Effects of moderate dietary supplementations with n-3 fatty acids on macrophage and lymphocyte phospholipids and macroophage eicosanoid synthesis in the rat. Biochim Biophys Acta. 1047:1990;19-28.
21. Bourre J.M., Boneil M., Dumont O., et al. Effect of increasing amounts of dietary fish oil on brain and liver fatty composition. Biochim Biophys Acta. 1043:1990;149-152.
22. Chapkin R.S., Miller C.C. Chain elongation of eicosapentaenoic acid in macrophage. Biochim Biophys Acta. 1042:1990;265-267.