Metabolism of a thiazole benzenesulfonamide derivative, a potent and selective agonist of the human β3-adrenergic receptor, in rats: Identification of a novel isethionic acid conjugate

Drug Metabolism and Disposition

Volumn 30, Issue 7, 2002, Pages 778-787

  Tang, Wei ^a   Stearns, Ralph A ^b   Miller, Randall R ^a   Ngui, Jason S ^b   Mathvink, Robert J ^a   Weber, Ann E ^a   Kwei, Gloria Y ^a   Strauss, John R ^b   Keohane, Carol A ^b   Doss, George A ^a   Chiu, Shuet Hing L ^b   Baillie, Thomas A ^a  

^a Department of Drug Metabolism ^*  (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; BENZENESULFONAMIDE DERIVATIVE; BETA 3 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; COENZYME A; CYTOCHROME P450 3A4; GLYCOPROTEIN P; ISETHIONIC ACID; N [4 [2 [[2 HYDROXY 2 (PYRIDIN 3 YL)ETHYL]AMINO]ETHYL]PHENYL] 4 [4 (4 TRIFLUOROMETHYLPHENYL)THIAZOL 2 YL]BENZENESULFONAMIDE; TAURINE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; VINBLASTINE; BENZENESULFONAMIDE; SULFONAMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE; CONTROLLED STUDY; DOG; DRUG CONJUGATION; DRUG DETERMINATION; DRUG EXCRETION; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG TRANSPORT; HUMAN; HUMAN TISSUE; LIVER MICROSOME; MALE; MONKEY; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; CELL LINE; CHEMISTRY; DRUG POTENTIATION; FEMALE; MACACA; METABOLISM; MOUSE; OXIDATION REDUCTION REACTION; SPRAGUE DAWLEY RAT; SWINE;

ANIMAL; CELL LINE; DOGS; FEMALE; HUMAN; ISETHIONIC ACID; MACACA MULATTA; MALE; MICE; MICROSOMES, LIVER; OXIDATION-REDUCTION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, BETA-3; SULFONAMIDES; SWINE; THIAZOLES; ANIMALS; HUMANS;

ANIMALIA; CANIS FAMILIARIS;

EID: 0035987888     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.30.7.778     Document Type: Article

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