Role of the Legionella pneumophila rtxA gene in amoebae

Microbiology

Volumn 148, Issue 6, 2002, Pages 1667-1677

  Cirillo, Suat L G ^a   Yan, Ling ^a   Littman, Michael ^a   Samrakandi, Mustapha M ^a   Cirillo, Jeffrey D ^a  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

Author keywords

Amoeba; Lysosomes; Pathogenesis; Phagocytosis; Pneumonia

Indexed keywords

ACANTHAMOEBA CASTELLANII; AEROSOL; AQUATIC ENVIRONMENT; ARTICLE; BACTERIAL CELL; BACTERIAL GENE; BACTERIUM ADHERENCE; BACTERIUM ISOLATE; CELL DIVISION; CELL SURVIVAL; CONTROLLED STUDY; GENE IDENTIFICATION; GENE INTERACTION; HOST CELL; INTRACELLULAR TRANSPORT; LEGIONELLA PNEUMOPHILA; LEGIONNAIRE DISEASE; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; SOUTHERN BLOTTING; SPECIES DISTRIBUTION; WATER SUPPLY; ACANTHAMOEBA; ANIMAL; CELL VACUOLE; CYTOLOGY; DISEASE CARRIER; DISEASE TRANSMISSION; ENVIRONMENT; GENETICS; LYSOSOME; METABOLISM; MICROBIOLOGY; MOVEMENT (PHYSIOLOGY); PARASITOLOGY; PATHOGENICITY; PHYSIOLOGY; ULTRASTRUCTURE;

ACANTHAMOEBA; ACANTHAMOEBA CASTELLANII; ANIMALIA; BACTERIA (MICROORGANISMS); LEGIONELLA; LEGIONELLA PNEUMOPHILA; NEGIBACTERIA; PROTOZOA;

BACTERIAL TOXIN; RTXA PROTEIN, BACTERIA;

ACANTHAMOEBA; ANIMALS; BACTERIAL ADHESION; BACTERIAL TOXINS; BLOTTING, SOUTHERN; DISEASE RESERVOIRS; ENVIRONMENT; GENES, BACTERIAL; LEGIONELLA PNEUMOPHILA; LEGIONNAIRES' DISEASE; LYSOSOMES; MOVEMENT; VACUOLES;

EID: 0035987244     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/00221287-148-6-1667     Document Type: Article

References (83)

1. The phagosome containing Legionella pneumophila within the protozoan Hartmannella vermiformis is surrounded by the rough endoplasmic reticulum
2. Immunological similarity between the 170 kD amoebic adherence glycoprotein and human beta 2 integrins
3. Phagocytosis in Acanthamoeba: I. A mannose receptor is responsible for the binding and phagocytosis of yeast
4. Phagocytosis in Acanthamoeba: II. Soluble and insoluble mannose-rich ligands stimulate phosphoinositide metabolism
5. The leukotoxin of Pasteurella haemolytica binds to β2 integrins on bovine leukocytes
6. Interaction of L. pneumophila and a free living amoeba (Acanthamoeba palestinensis)
7. Response of cultured macrophages to Mycobacterium tuberculosis with observations on fusion of lysosomes with phagosomes
8. Hydrogen peroxide mediates amyloid beta protein toxicity
9. Altered intracellular targeting properties associated with mutations in the Legionella pneumophila dotA gene
10. Effects of Escherichia coli hemolysin on human monocytes. Cytocidal action and stimulation of interleukin 1 release
11. Recognition of a second serogroup of Legionella longbeachae
12. Isolation and characterization of a seventh serogroup of Legionella pneumophila
13. Kinetics of phagocytosis and phagosome-lysosome fusion in hamster lung and peritoneal macrophages
14. The fine structure of Acanthamoeba castellanii. I. The trophozoite
15. Interaction of Legionella pneumophila with Acanthamoeba castellanii: Uptake by coiling phagocytosis and inhibition of phagosome-lysosome fusion
16. Carrier-mediated uptake and presentation of a major histocompatibility complex class I-restricted peptide
17. Legionella bozemanii sp. nov. and Legionella dumoffii sp. nov.: Classification of two additional species of Legionella associated with human pneumonia
18. Coinoculation with Hartmannella vermiformis enhances replicative Legionella pneumophila lung infection in a murine model of Legionnaires' disease
19. Intrapulmonary Hartmannella vermiformis: A potential niche for Legionella pneumophila replication in a murine model of legionellosis
20. The role of Legionella pneumophila-infected Hartmannella vermiformis as an infectious particle in a murine model of Legionnaires' disease
21. Molecular evolution of integrins: Genes encoding integrin β subunits from a coral and a sponge
22. Carbohydrate binding proteins involved in phagocytosis by Acanthamoeba
23. Legionella sainthelensi: A new species of Legionella isolated from water near Mt. St. Helens
24. Legionella pneumophila mip gene potentiates intracellular infection of protozoa and human macrophages
25. Growth of Legionella pneumophila in Acanthamoeba castellanii enhances invasion
26. Interaction of Mycobacterium avium with environmental amoebae enhances virulence
27. Intracellular growth in Acanthamoeba castellanii affects monocyte entry mechanisms and enhances virulence of Legionella pneumophila
28. Identification of novel loci involved in entry by Legionella pneumophila
29. Legionella pneumophila entry gene rtxA is involved in virulence
30. Chemiluminescence and superoxide production in Acanthamoeba castellanii: Free radicals generated during oxidative stress
31. Superoxide generation during phagocytosis by Acanthamoeba castellanii: Similarities to the respiratory burst of immune phagocytes
32. The kinetics of early inflammatory events during experimental pneumonia due to Legionella pneumophila in guinea pigs
33. Improved semiselective medium for isolation of Legionella pneumophila from contaminated clinical and environmental specimens
34. Cloning and expression of Legionella pneumophila antigens in Escherichia coli
35. Molecular Koch's postulates applied to microbial pathogenicity
36. Comparison of guinea pig and protozoan models for determining virulence of Legionella species
37. Mutants of Salmonella typhimurium that cannot survive within the macrophage are avirulent
38. Ecological distribution of Legionella pneumophila
39. Ruffles induced by Salmonella and other stimuli direct macropinocytosis of bacteria
40. Utilization of similar mechanisms by Legionella pneumophila to parasitize two evolutionarily distant host cells, mammalian macrophages and protozoa
41. Adenylate cyclase toxin is critical for colonization and pertussis toxin is critical for lethal infection by Bordetella pertussis in infant mice
42. Legionella anisa: A new species of Legionella isolated from potable waters and a cooling tower
43. Differential interaction with endocytic and exocytic pathways distinguish parasitophorous vacuoles of Coxiella burnettii and Chlamydia trachomatis
44. Association between Legionella pneumophila and amoebae in water
45. A new Legionella species, Legionella feeleii species nova, causes Pontiac fever in an automobile plant
46. Formation of a novel phagosome by the Legionnaires' disease bacterium (Legionella pneumophila) in human monocytes
47. Phagocytosis of the Legionnaires' disease bacterium (Legionella pneumophila) occurs by a novel mechanism: Engulfment within a pseudopod coil
48. Legionella pneumophila inhibits acidification of its phagosome in human monocytes
49. Development of a standardized sub-grouping scheme for Legionella pneumophila serogroup 1 using monoclonal antibodies
50. Evidence that Dot-dependent and -independent factors isolate the Legionella pneumophila phagosome from the endocytic network in mouse macrophages
51. Mechanism of Escherichia coli alpha-hemolysin-induced injury to isolated renal tubular cells
52. Evidence for pore forming ability by Legionella pneumophila
53. RTX toxins recognize a β2 integrin on the surface of human target cells
54. Phagocytic recognition mechanisms in human granulocytes and Acanthamoeba castellanii using type 1 fimbriated Escherichia coli as phagocytic prey
55. Preliminary findings of a community-based pneumonia incidence study
56. Surveillance for Legionnaires' disease
57. Inhibition of macrophage phagocytosis by Pseudomonas aeruginosa rhamnolipids in vitro and in vivo
58. A quantitative model of intracellular growth of Legionella pneumophila in Acanthamoeba castellanii
59. Isolation of Legionnaires' disease bacterium from environmental samples
60. Legionella gormanii sp. nov
61. Interaction between the Legionnaires' disease bacterium (Legionella pneumophila) and human alveolar macrophages
62. Interactions between Naegleria fowleri and Legionella pneumophila
63. Processing of free-living amoebae for transmission electron microscopy
64. Association of flagellum expression and intracellular growth of Legionella pneumophila
65. Legionella pneumonia in the United States: The distribution of serogroups and species causing human illness
66. Preliminary report on the pathogenicity of Legionella pneumophila for freshwater and soil amoeba
67. Current views on the relationships between amoebae, legionellae and man
68. Legionella-like amoebal pathogens
69. Legionella pneumophila DotA protein is required for early phagosome trafficking decisions that occur within minutes of bacterial uptake
70. Bacterial adherence and hemolysin production from Escherichia coli induces histamine and leukotriene release from various cells
71. Legionella pneumophila utilizes the same genes to multiply within Acanthamoeba castellanii and human macrophages
72. AUT3, a serine/threonine kinase gene, is essential for autophagocytosis in Saccharomyces cerevisiae
73. Fluorescent labeling of endocytic compartments
74. Association of Legionella pneumophila with the macrophage endoplasmic reticulum
75. Identification of Legionella pneumophila mutants that have aberrant intracellular fates
76. Identification of a Gal/GalNAc lectin in the protozoan Hartmanella vermiformis as a potential receptor for attachment and invasion by the Legionnaires' disease bacterium, Legionella pneumophila
77. 2 integrin motif
78. Pore-forming cytolysin of Gram-negative bacteria
79. Early events in phagosome establishment are required for intracellular survival of Legionella pneumophila
80. Legionella moravica sp. nov. and Legionella brunensis sp. nov. isolated from cooling-tower water
81. The pathology of Legionella pneumonias. A review of 74 cases and the literature
82. Lack of evidence for person-to-person transmission of Legionnaires' disease
83. Pore-forming activity is not sufficient for Legionella pneumophila phagosome trafficking and intracellular growth