p75 and TrkA receptors are both required for uptake of NGF in adult sympathetic neurons: Use of a novel fluorescent NGF conjugate

Brain Research

Volumn 920, Issue 1-2, 2001, Pages 226-238

  Gatzinsky, Kliment P ^a   Haugland, Rosaria P ^b   Thrasivoulou, Christopher ^c   Orike, Nina ^c   Budi Santoso, Agus W ^c   Cowen, Timothy ^c  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b MOLECULAR PROBES INC   (United States)

^c ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

Antibody receptor blockade; Confocal microscopy; NGF transport; Rat; Superior cervical ganglion

Indexed keywords

ANTIBODY; DEXTRAN; FLUORESCENT DYE; NERVE GROWTH FACTOR; NEUROTROPHIN RECEPTOR; PROTEIN P75; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ARTICLE; CELL COUNT; CELL LABELING; CELL SURVIVAL; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONJUGATE; CONTROLLED STUDY; IMAGE ANALYSIS; IRIS; MALE; NERVE ENDING; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; RECEPTOR BLOCKING; SIGNAL TRANSDUCTION; SUPERIOR CERVICAL GANGLION; SYMPATHETIC NERVE CELL;

EID: 0035976591     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)03099-2     Document Type: Article

References (75)

1. Target-specific differences in the dendritic morphology and neuropeptide content of neurons in the rat SCG during development and aging
2. LNTR reduced NGF binding to trkA on PC12 cells
3. NGFR defines high affinity NGF binding
4. Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness
5. Trk receptors function as rapid retrograde signal carriers in the adult nervous system
6. Functional interactions of neurotrophins and neurotrophin receptors
7. p75NTR and apoptosis: Trk-dependent and Trk-independent effects
8. NGFR-associated protein kinase
9. Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75
10. Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75
11. p75 neurotrophin receptor as a modulator of survival and death decisions
12. Neurotrophin receptors: A window into neuronal differentiation
13. The p75 neurotrophin receptor
14. p75 and Trk: A two-receptor system
15. TrkA cross-linking mimics neuronal responses to nerve growth factor
16. Sympathetic and sensory axons invade the brains of nerve growth factor transgenic mice in the absence of p75NTR expression
17. Plasticity in adult and ageing sympathetic neurons
18. Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons
19. Differential role of the low affinity neurotrophin receptor (p75) in retrograde axonal transport of the neurotrophins
20. The neurotrophic hypothesis: Where does it stand?
21. p75-deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins
22. Neurotrophin receptors
23. Diabetes and axotomy-induced deficits in retrograde axonal transport of nerve growth factor correlate with decreased levels of p75LNTR protein in lumbar dorsal root ganglia
24. Reversible blocking of amino groups with citraconic anhydride
25. Activation of the sphingomyelin cycle through the low affinity neurotrophin receptor
26. NGF-stimulated retrograde transport of trkA in the mammalian nervous system
27. Target derived and putative local actions of neurotrophins in the peripheral nervous system
28. Induction of cell death by endogenous nerve growth factor through its p75 receptor
29. Neurotrophin signaling via Trks and p75
30. Modulation of nerve growth factor internalization by direct interaction between p75 and TrkA receptors
31. Responsiveness of sympathetic and sensory irideal nerves to NGF treatment in young and aged rats
32. Nerve growth factor activation of nuclear factor kappa B through its p75 receptor is an anti-apoptotic signal in RN22 schwannoma cells
33. Endocytosis of activated TrkA: Evidence that nerve growth factor induces formation of signaling endosomes
34. A signaling organelle containing the nerve growth factor-activated receptor tyrosine kinase, TrkA
35. The low affinity NGF receptor, p75, can collaborate with each of the Trks to potentiate functional responses to the neurotrophins
36. Levels of nerve growth factor and neurotrophin-3 are affected differentially by the presence of p75 in sympathetic neurons in vivo
37. Multiple trkA proteins in PC12 cells bind NGF with a slow association rate
38. Coupling of monoclonal antibodies with fluorophores
39. High affinity binding requires co-expression of the trk proto-oncogene and the low affinity NGF receptor
40. In vivo administration of nerve growth factor
41. A second messenger required for nerve growth factor biological activity?
42. A potential interaction of p75 and trkA NGF receptors revealed by affinity crosslinking and immunoprecipitation
43. Nerve growth factor mediates signal transduction through trk homodimer receptors
44. Expression and structure of the human NGF receptor
45. Nerve growth factor receptor on rat glial cell lines. Evidence for NGF internalization via p75NGFR
46. trkA kinase activity, but not ligand internalization, in PC12 cells
47. Flow cytometric analysis of fluorescein-labelled nerve growth factor binding to A875 human melanoma cells
48. NTR neuronal expression and nerve growth factor
49. Blocking nerve growth factor binding to the p75 neurotrophin receptor on sympathetic neurons transiently reduces trkA activation but does not affect neuronal survival
50. p75-deficient embryonic dorsal root sensory and neonatal sympathetic neurons display a decreased sensitivity to NGF
51. Mobility, clustering, and transport of nerve growth factor in embryonal sensory cells and in a sympathetic neuronal cell line
52. Optimal nerve growth factor trophic signals mediated by synergy of TrkA and p75 receptor-specific ligands
53. Molecular investigations on the high affinity nerve growth factor receptor
54. The p75 receptor: First insights into the transduction mechanisms leading to either cell death or survival
55. Nerve growth factor derived from terminals selectively increases the ratio of p75 to trka NGF receptors on mature sympathetic neurons
56. Serum free culture of dissociated, purified adult and ageing sympathetic neurons and quantitative assays of growth and survival
57. Differential regulation of survival and growth in adult sympathetic neurons: An in vitro study of neurotrophin responsiveness
58. Gene transfer and molecular cloning of the rat nerve growth factor receptor
59. 125I-nerve growth factor in vivo
60. An NGF-TrkA-mediated retrograde signal to transcription factor CREB in sympathetic neurons
61. Internalization of nerve growth factor by pheochromocytoma PC12 cells: Absence of transfer to the nucleus
62. The neurotrophin receptor, gp75, forms a complex with the receptor tyrosine kinase TrkA
63. p75 and TrkA receptor signaling independently regulate amyloid precursor protein mRNA expression, isoform composition, and protein secretion in PC12 cells
64. Ultrastructural localization of a nerve growth factor-horseradish peroxidase (NGF-HRP) coupling product after retrograde axonal transport in adrenergic neurons
65. Intracellular signaling pathways activated by neurotrophic factors
66. Rapid retrograde tyrosine phosphorylation of trkA and other proteins in rat sympathetic neurons in compartmented cultures
67. Characterization of the binding properties and retrograde axonal transport of a monoclonal antibody directed against the rat nerve growth factor receptor
68. Regulation of rat sympathetic nerve density by target tissues and NGF in maturity and old age
69. 125I-nerve growth factor in rat sympathetic neurons in compartmented cultures
70. p75 LNGFR regulates Trk signal transduction and NGF-induced neuronal differentiation in MAH cells
71. Evidence that biological activity of NGF is mediated through a novel subclass of high affinity receptors
72. Interaction with TrkA immobilizes gp75 in the high affinity nerve growth factor receptor complex
73. Regulation of expression of mRNAs encoding the nerve growth factor receptors p75 and trka in developing sensory neurons
74. Regulation of nerve growth factor receptor gene expression in sympathetic neurons during development
75. Competitive signalling between trkA and p75 nerve growth factor receptors determines cell survival