New 3′-azido-3′-deoxythymidin-5′-yl O-(4-hydroxyalkyl or -alkenyl or -alkylepoxide) carbonate prodrugs: Synthesis and anti-HIV evaluation

Journal of Medicinal Chemistry

Volumn 44, Issue 18, 2001, Pages 3014-3021

  Vlieghe, P ^a,b   Clerc, T ^b   Pannecouque, C ^c   Witvrouw, M ^c   De Clercq, E ^c   Salles, J P ^b   Kraus, J L ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b Laboratoire LAPHAL   (France)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

3' AZIDO 3' DEOXYTHYMIDIN 5' YL O (4 HYDROXYEPOXIDE)CARBONATE; ALKENYL GROUP; ALKYL GROUP; CARBONIC ACID DERIVATIVE; EPOXIDE; PRODRUG; THYMIDINE DERIVATIVE; UNCLASSIFIED DRUG; ZIDOVUDINE; ZIDOVUDINE DERIVATIVE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; DRUG DERIVATIVE;

ARTICLE; CYTOTOXICITY; DRUG GLUCURONIDATION; DRUG HALF LIFE; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; THERMODYNAMICS; CELL CULTURE; CHEMISTRY; DRUG STABILITY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTI-HIV AGENTS; CELLS, CULTURED; DRUG STABILITY; HUMANS; PRODRUGS; STRUCTURE-ACTIVITY RELATIONSHIP; ZIDOVUDINE;

EID: 0035974621     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010863i     Document Type: Article

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