Autophosphorylation dependent destabilization of the insulin receptor kinase domain: Tryptophan-1175 reports changes in the catalytic cleft

Biochemistry

Volumn 38, Issue 10, 1999, Pages 3079-3089

  Bishop, Steven M ^a,b   Ross, J B Alexander ^a   Kohanski, Ronald A ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN RECEPTOR KINASE; TRYPTOPHAN;

ARTICLE; AUTOPHOSPHORYLATION; CATALYSIS; CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME DENATURATION; ENZYME REGULATION; ENZYME STABILITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; PRIORITY JOURNAL; PROTEIN DOMAIN; STRUCTURE ANALYSIS;

AMINO ACID SUBSTITUTION; CATALYTIC DOMAIN; ENZYME STABILITY; FLUORESCENCE POLARIZATION; GUANIDINE; HUMANS; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; PHENYLALANINE; PHOSPHORYLATION; PROTEIN DENATURATION; PROTEIN STRUCTURE, SECONDARY; RECEPTOR, INSULIN; SPECTROMETRY, FLUORESCENCE; THERMODYNAMICS; TRYPTOPHAN;

EID: 0033537695     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi982546s     Document Type: Article

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