Induction of a Germline Mutation at a Hypervariable Mouse Minisatellite Locus by 252Cf Radiation

Journal of Radiation Research

Volumn 37, Issue 3, 1996, Pages 217-224

  Niwa, Ohtsura ^a   Fan, Yi Jun ^a   Numoto, Michitaka ^a   Kamiya, Kenji ^a   Kominami, Ryo ^b  

^a HIROSHIMA UNIVERSITY   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

Author keywords

Germline mutation; Minisatellite locus; Mouse; Neutrons

Indexed keywords

GAMMA RAYS; MAMMALS; NEUTRON IRRADIATION; NEUTRONS;

EXPOSED TO; GERMLINE; GERMLINE MUTATION; HIGH FREQUENCY HF; HYPERVARIABLES; MALE MOUSE; MINI-SATELLITES; MINISATELLITE LOCUS; MOUSE; MUTATION FREQUENCY;

GENES;

CALIFORNIUM; RADIOISOTOPE;

ALLELE; ANIMAL; ARTICLE; FEMALE; MALE; MOUSE; MUTATION; PREGNANCY; RADIATION EXPOSURE; SPERMATOZOON; VARIABLE NUMBER OF TANDEM REPEAT;

ALLELES; ANIMALS; CALIFORNIUM; FEMALE; GERM-LINE MUTATION; MALE; MICE; MINISATELLITE REPEATS; PREGNANCY; RADIOISOTOPES; SPERMATOZOA;

EID: 0030227877     PISSN: 04493060     EISSN: None     Source Type: Journal    
DOI: 10.1269/jrr.37.217     Document Type: Article

References (23)

1. Russell, W. L. (1951) X-ray-induced mutation in mice. Cold Spring Harbor Symposium on Quantitative Biology 16: 327-336.
2. Neel, J. V., Schull, W. J., Awa, A. A., Sato, C., Kato, H., Ohtake, M. and Yoshimoto, Y. (1990) The children of parents exposed to atomic bomb: estimates of the genetic doubling dose of radiation for humans. Am. J. Hum. Genet. 46: 1053-1072.
3. Jeffreys, A. J., Wilson, V. and Thein, S. L. (1985) Hypervariable "minisatellite" regions in human DNA. Nature 316: 67-73.
4. Kelly, R., Bulfield, G., Collick, A., Gibbs, M. and Jeffreys, A. J. (1989) Characterization of a highly unstable mouse minisatellite locus: evidence for somatic mutation during early development. Genomics 5: 844-856.
5. Mitani, K., Takahashi, Y. and Kominami, R. (1990) A GGCAGG motif in minisatellite affecting their germline instability. J. Biol. Chem. 265: 15203-15210.
6. Dubrova, Y. E., Jeffreys, A. J. and Malashenko. A. M. (1993) Mouse minisatellite mutations induced by ionizing radiation. Nature Genet. 5: 92-94.
7. Sadamoto, S., Suzuki, S., Kamiya, K., Kominami, R., Dohi, K. and Niwa, O. (1994) Radiation induction of germline mutation at a hypervariable mouse minisatellite locus. Int. J. Radiat. Biol. 65: 549-557.
8. Fan, Y-J., Wang, Z., Sadamoto, S., Ninomiya, Y., Kotomura, N., Kamiya, K., Dohi, K., Kominami, R. and Niwa, O. (1995) Dose-response of a radiation induction of a germline mutation at a hypervariable mouse minisatellite locus. Int. J. Radiat. Biol. 68: 177-183.
9. Kodaira, M., Satoh, C., Hiyama, K. and Toyama, K. (1995) Lack of effects of atomic bomb radiation on genetic instability of tandem-repetitive elements in human germ cells. Am. J. Hum. Genet. 57: 1275-1283.
10. Dubrova, Y. E., Nesterov, V. N., Krouchinsky, N. G., Ostapenko, V. A., Neuman, R., Neil, D. L. and Jeffreys, A. J. (1996) Human minisatellite mutation rate after the Chernobyl accident. Nature 380: 683-686.
11. 252Cf fission neutrons. J. Radiat. Res. 37: 49-57.
12. ICRU Report 26 (1977) Neutron dosimetry for biology and medicine. International Commission on Radiation Units and Measurements, Washington DC, pp55.
13. 252Cf beam for use in radiobiology studies at Hiroshima University. Phys. Med. Biol. 33: 473-480.
14. Southern, E. M. (1975) Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98: 505-513.
15. Sotomayor, R. E., Sega, G. A. and Cumming, R. B. (1979) An autoradiographic study of unscheduled DNA synthesis in the germ cells of male mice treated with X-ray and methylmethenesulfonate. Mutat. Res. 162: 549-557.
16. Inoue, M., Kurihara, T., Yamashita, M. and Tatsumi, K. (1993) Effects of treatment with methylmethenesulfonate during meiotic and postmeiotic stages and maturation of spermatozoa in mice. Mutat. Res. 249: 179-186.
17. Komatsu, K., Sawada, S., Takeoka, S., Kodama, S. and Okumura, Y. (1993) Dose-rate effects of neutrons and gamma-rays on the induction of mutation and oncogenic transformation in plateau-phase mouse m5S cells. Int. J. Radiat. Biol. 63: 469-474.
18. Nakamura, N. and Sawada, S. (1988) Reverse dose-rate effect and RBE of 252-califbrnium radiation in the induction of 6-thioguanine-resistant mutations in mouse L5178Y cells. Mutat. Res. 201: 65-71.
19. Ban, S., Donovan, M. P., Cologne, J. B. and Sawada, S. (1991) Gamma-ray- and fission neutron-induced micronuclei in PHA stimulated and unstimulated human lymphocytes. J. Radiat. Res. 32: 13-22.
20. Rinchik, E. M., Stoye, J. P., Frankel, W. N., Coffin, J., Kwon. B. S. and Russell, L. B. (1993) Molecular analysis of viable spontaneous and radiation-induced albino(c)-locus mutations in the mouse. Mutat. Res. 286: 199-207.
21. Monkton, D. G., Neumann, R., Guram, T., Fretwell, N., Tamaki, K., MacLeod, A. and Jeffreys, A. (1994) Minisatellite mutation rate variation associated with a flanking DNA sequence polymorphism. Nature Genet. 8: 162-170.
22. Schiestl, R. H., Khogali, F. and Carls, N. (1994) Reversion of the mouse pink-eyed unstable mutation induced by low doses of X-rays. Science 266: 1573-1575.
23. Niwa, O., Saigusa, T., Ikushima, T. and Sugahara, T. (1987) Activation of endogenous retroviruses in mouse cells by thermal neutrons. Int. J. Radiat. Biol. 52: 949-956.