Mitogen-activated protein (MAP) kinases are involved in interleukin-1 (IL-1)-induced IL-6 synthesis in osteoblasts: Modulation not of p38 MAP kinase, but of p42/p44 MAP kinase by IL-1-activated protein kinase C

Endocrinology

Volumn 140, Issue 11, 1999, Pages 5120-5125

  Miwa, Masaichi ^a   Kozawa, Osamu ^b   Tokuda, Haruhiko ^c   Uematsu, Toshihiko ^b  

^a Gifu Social Insurance Hospital   (Japan)

^b GIFU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c CHUBU NATIONAL HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CALPHOSTIN C; ENZYME ACTIVATOR; INTERLEUKIN 1ALPHA; INTERLEUKIN 2; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C; PROTEIN KINASE INHIBITOR; TRICYCLO[4.3.0.1]DECAN 9 YL XANTHOGENATE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; MODULATION; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL;

EID: 0033303675     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.140.11.7123     Document Type: Article

References (33)

1. Neuroendocrine-immune system interactions and autoimmunity
2. Biologic basis for interleukin-1 in disease
3. Cells of bone: Proliferation, differentiation, and hormonal regulation
4. IL-6 is produced by osteoblasts and induces bone resorption
5. Interleukin-6 is involved in interleukin-1-induced activities
6. Interleukin-6 is produced by bone and modulated by parathyroid hormone
7. Platelet-derived growth factor stimulates the synthesis of interleukin-6 in cells of the osteoblast lineage
8. Interleukin-6: An osteotropic factor?
9. Protein kinase C activation by interleukin (IL)-1 limits IL-1-induced IL-6 synthesis in osteoblast-like cells: Involvement of phosphatidylcholine-specific phospholipase C
10. The MAP kinase cascade is essential for diverse signal transduction pathways
11. Parathyroid hormone inhibits mitogen-activated protein kinase activation in osteosarcoma cells via a protein kinase A-dependent pathway
12. Forskolin inhibits protein kinase C-induced mitogen activated protein kinase activity in MC3T3-E1 osteoblasts
13. Activation of extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2) by FGF-2 and PDGF-BB in normal human osteoblastic and bone marrow stromal cells: Differences in mobility and in-gel renaturation of ERK1 in human, rat, and mouse osteoblastic cells
14. Identification and activation of mitogen-activated protein (MAP) kinase in normal human osteoblastic and bone marrow stromal cells: Attenuation of MAP kinase activation by cAMP, parathyroid hormone and forskolin
15. 2-terminal kinases by interleukin-1β in normal human osteoblastic and rat UMR-106 cells
16. The effects of IL-1 on mitogen-activated protein kinases in rabbit articular chondrocytes
17. Regulation of interleukin-1β-induced interleukin-6 gene expression in human fibroblast-like synoviocytes by p38 mitogen-activated protein kinase
18. Establishment of a clonal osteogenic cell line from newborn mouse calvaria
19. In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria
20. 2 in osteoblast-like cells
21. Different protein kinase C isozymes could modulate bradykinin-induced extracellular calcium-dependent and -independent increases in osteoblast-like MC3T3-E1 cells
22. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
23. Modulation of the stress-induced synthesis of hsp27 and αB-crystallin by cyclic AMP in C6 rat glioma cells
24. PD098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
25. A synthetic inhibitor of the mitogen-activated protein kinase cascade
26. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
27. SB203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
28. Studies and perspectives of protein kinase C
29. Calphostin C, (UCN-1029C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C
30. TNF activates NF-(κ)B by phosphatidylcholine-specific phospholipase C-induced 'acidic' sphingomyelin breakdown
31. Prostaglandin F(2α) stimulates interleulin-6 synthesis via activation of PKC in osteoblast-like cells
32. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
33. Prostaglandin F(2α) stimulates tyrosine phosphorylation and mitogen-activated protein kinase in osteoblastic MC3T3-E1 cells via protein kinase C activation