Telomerase activity of the Lugol-stained and -unstained squamous epithelia in the process of oesophageal carcinogenesis

British Journal of Cancer

Volumn 85, Issue 7, 2001, Pages 1006-1013

  Inai, M ^a   Kano, M ^a   Shimada, Y ^a   Sakurai, T ^b   Chiba, T ^a   Imamura, M ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

Lugol; Oesophagus; Squamous cell carcinoma; Telomerase

Indexed keywords

LUGOL; MESSENGER RNA; RNA DIRECTED DNA POLYMERASE; TELOMERASE;

ARTICLE; CARCINOGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOSCOPY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; ESOPHAGUS CARCINOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; SQUAMOUS EPITHELIUM;

CARCINOMA, SQUAMOUS CELL; CELL TRANSFORMATION, NEOPLASTIC; COLORING AGENTS; DNA-BINDING PROTEINS; ENDOSCOPY; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESOPHAGEAL NEOPLASMS; ESOPHAGITIS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IODIDES; RNA, MESSENGER; TELOMERASE; UP-REGULATION;

EID: 0035964586     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6692032     Document Type: Article

References (46)

1. Telomerase is active in normal gastrointestinal mucosa and not up-regulated in precancerous lesions
2. Telomerase activity: A biomarker of cell proliferation not malignant transformation
3. Telomerase activity associated with acquisition of malignancy in human colorectal cancer
4. Possible role of telomerase activation in the cancer predisposition of patients with hereditary nonpolyposis colorectal cancers
5. Polymerase chain reaction-based enzyme immunoassay for quantitation of telomerase activity: Application to colorectal cancers
6. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
7. Mucosal iodine staining improves endoscopic visualization of squamous dysplasia and squamous cell carcinoma of the esophagus in Linxian, China
8. Correlation of p53 mutations with epidermal growth factor receptor overexpression and absence of mdm2 amplification in human esophageal carcinomas
9. Telomerase activity in human leukemic cell lines is inhibited by antisense pentadecadeoxynucleotides targeted against c-myc mRNA
10. Creation of human tumour cells with defined genetic elements
11. Telomerase activity in the regenerative basal layer of the epidermis in human skin and in immortal and carcinoma-derived skin keratinocytes
12. Telomerase activity in human intestine
13. Telomerase activity in small-cell and non-small-cell lung cancers
14. Regulation of telomerase activity in immortal cell lines
15. Telomerase activity in precancerous hepatic nodules
16. Detection of telomerase activity in esophageal squamous cell carcinoma and normal esophageal epithelium
17. Decrease in telomerase activity in U-87MG human glioblastomas after treatment with an antagonist of growth hormone-releasing hormone
18. Specific association of human telomerase activity with immortal cells and cancer
19. Regulation of telomerase activity in quiescent immortalized human cells
20. Clinical significance of telomerase activity in the non-cancerous epithelial region of oesophageal squamous cell carcinoma
21. Telomerase activity as an indicator of malignant potential in iodine-nonreactive lesions of the esophagus
22. Molecular basis of artifacts in the detection of telomerase activity and a modified primer for a more robust 'TRAP' assay
23. Serial histologic evaluation of multiple primary squamous cell carcinomas of the esophagus
24. Amplification of the EGF receptor and c-myc genes in human esophageal cancers
25. Lugol staining pattern and histology of esophageal lesions
26. The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats
27. Telomerase catalytic subunit homologs from fission yeast and human
28. Quantitative reevaluation of telomerase activity in cancerous and noncancerous gastrointestinal tissues
29. The clinicopathologic significance of small areas unstained by Lugol's iodine in the mucosa surrounding resected esophageal carcinoma
30. Telomerase activity and expression of telomerase RNA component and telomerase catalytic subunit gene in cervical cancer
31. Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas
32. Estimates of the worldwide incidence of 25 major cancers in 1990
33. Expression of the human telomerase reverse transcriptase is not related to telomerase activity in normal and malignant renal tissue
34. Differences in diagnostic criteria for esophageal squamous cell carcinoma between Japanese and Western pathologists
35. Relationship between myc oncogene activation and MHC class I expression
36. Characterization of 21 newly established esophageal cancer cell lines
37. Clinicopathologic study of early stage esophageal carcinoma
38. Immuno-histochemical detection of human telomerase catalytic component, hTERT, in human colorectal tumor and non-tumor tissue sections
39. Expression of human telomerase subunits and correlation with telomerase activity in cervical cancer
40. Telomerase activity in esophageal carcinoma
41. Detection of telomerase activity in malignant and nonmalignant skin conditions
42. Myc activates telomerase
43. Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity
44. Direct activation of TERT transcription by c-MYC
45. Telomerase activity and in situ telomerase RNA expression in malignant and non-malignant lymph nodes