Inhibitors of arterial relaxation among components of human oxidized low-density lipoproteins: Cholesterol derivatives oxidized in position 7 are potent inhibitors of endothelium-dependent relaxation

Circulation

Volumn 95, Issue 3, 1997, Pages 723-731

  Deckert, Valérie ^a   Perségol, Laurence ^a   Viens, Laurence ^a   Lizard, Gérard ^a   Athias, Anne ^a   Lallemant, Christian ^a   Gambert, Philippe ^a   Lagrost, Laurent ^a,b  

^a INSERM   (France)

^b HÔPITAL DU BOCAGE   (France)

Author keywords

acetylcholine; cholesterol; endothelium; lipoproteins; vessels

Indexed keywords

ACETYLCHOLINE; CHOLESTEROL DERIVATIVE; FATTY ACID; LOW DENSITY LIPOPROTEIN;

ADULT; ANIMAL CELL; ARTERY DILATATION; ARTICLE; ATHEROSCLEROSIS; BLOOD VESSEL REACTIVITY; CHOLESTEROL METABOLISM; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; HUMAN; HYPERLIPIDEMIA; LIPID OXIDATION; MALE; NONHUMAN; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM;

EID: 0031046475     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.95.3.723     Document Type: Article

References (12)

1. Henry PD, Yokoyama M. Supersensitivity of atherosclerotic rabbit aorta to ergonovine. J Clin Invest. 1980;66:306-313.
2. Yokoyama M, Akita H, Mizutani T, Fukuzaki H, Watanabe Y. Hyperreactivity of coronary arterial smooth muscles in response to ergonovine from rabbits with hereditary hyperlipidemia. Circ Res. 1983;53:63-71.
3. Heistad DD, Armstrong ML, Marcus ML, Piegors DJ, Mark AL. Augmented responses to vasoconstrictor stimuli in hypercholesterolemic and atherosclerotic monkeys. Circ Res. 1984;54:711-718.
4. Merkel LA, Rivera LM, Bilder GE, Perrone MH. Differential alteration of vascular reactivity in rabbit aorta with modest elevation of serum cholesterol. Circ Res. 1990;67:550-555.
5. Galle J, Busse R, Bassenge E. Hypercholesterolemia and atherosclerosis change vascular reactivity in rabbits by different mechanisms. Arterioscler Thromb. 1991;11:1712-1718.
6. Verbeuren TJ, Jordaens FH, Zonnekeyn LL, Van Hove CE, Coene M-C, Herman AG. Effect of hypercholesterolemia on vascular reactivity in the rabbit, I: endothelium-dependent and endothelium-independent contractions and relaxations in isolated arteries of control and hypercholesterolemic rabbits. Circ Res. 1986;58:552-564.
7. Jayakody L, Senaratne M, Thomson A, Kappagoda T. Endothelium-dependent relaxation in experimental atherosclerosis in the rabbit. Circ Res. 1987;60:251-264.
8. Zeiher AM, Drexler H, Wollschläger H, Just H. Modulation of coronary vasomotor tone in humans: progressive endothelial dysfunction with different early stages of coronary atherosclerosis. Circulation. 1991;83:391-401.
9. Reddy KG, Nair RN, Sheehan HM, Hodgson JM. Evidence that selective endothelial dysfunction may occur in the absence of angiographic or ultrasound atherosclerosis in patients with risk factors for atherosclerosis. J Am Coll Cardiol. 1994;23:833-843.
10. Celermajer DS, Sorensen KE, Bull C, Robinson J, Deanfield JE. Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction. J Am Coll Cardiol. 1994;24:1468-1474.
11. Jacobs M, Plane F, Bruckdorfer RK. Native and oxidized low-density lipoproteins have different inhibitory effects on endothelium-derived relaxing factor in the rabbit aorta. Br J Pharmacol. 1990;100:21-26.
12. Galle J, Mülsch A, Busse R, Bassenge E. Effects of native and oxidized low density lipoproteins on formation and inactivation of endothelium-derived relaxing factor. Arterioscler Thromb. 1991;11:198-203.