Accumulation and metabolism of low density lipoprotein-derived cholesteryl linoleate hydroperoxide and hydroxide by macrophages

Journal of Lipid Research

Volumn 39, Issue 12, 1998, Pages 2394-2405

  Kritharides, L ^a,b   Upston, J ^a   Jessup, W ^a   Dean, R T ^a  

^a HEART RESEARCH INSTITUTE   (Australia)

^b Hospital Concord   (Australia)

Author keywords

Atherosclerosis; Cholesterol; Cholesteryl ester hydroperoxide; Foam cell macrophage; Low density lipoprotein; Lysosome; Oxidation; Scavenger receptor

Indexed keywords

LOW DENSITY LIPOPROTEIN;

ARTICLE; ATHEROSCLEROSIS; FOAM CELL; HUMAN; HUMAN CELL; LIPID OXIDATION; LIPOPROTEIN METABOLISM; MACROPHAGE; NORMAL HUMAN; PRIORITY JOURNAL;

ACETYLATION; APOLIPOPROTEINS B; CHOLESTEROL ESTERS; ENDOSOMES; FREE RADICALS; HUMANS; HYDROGEN PEROXIDE; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; LIPID PEROXIDATION; LIPOPROTEINS, LDL; LYSOSOMES; MACROPHAGES; METABOLIC CLEARANCE RATE; OXIDATION-REDUCTION; REFERENCE VALUES;

EID: 0032414192     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Haberland, M. E., D. Fong, and L. Cheng. 1988. Malondialdehyde-altered protein occurs in atheroma of Watanabe heritable hyperlipidemic rabbits. Science. 241: 215-218.
2. Yla-Herttuala, S., W. Palinski, M. E. Rosenfeld, S. Parthasarathy, T. E. Carew, S. Butler, J. L. Witztum, and D. Steinberg. 1989. Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. J. Clin. Invest. 84: 1086-1095.
3. Steinberg, D., S. Parthasarathy, T. E. Carew, J. C. Khoo, and J. L. Witztum. 1989. Beyond cholesterol: modifications of low density lipoprotein that increase its athcrogenicity. N. Engl. J. Med. 320: 915-924.
4. Steinbrecher, U. P., H. Zhang, and M. Lougheed. 1990. Role of oxidatively modified LDL in atherosclerosis. Free Radical Biol. Med. 9: 155-168.
5. Suarna, C., R. T. Dean, J. May, and R. Stocker. 1995. Human atherosclerotic plaque contains oxidation products and relatively large quantities of alpha tocopherol and ascorbate. Arterioscler. Thromb. Vasc. Biol. 15: 1616-1624.
6. Hazell, L. J., L. Arnold, D. Flowers, G. Waeg, E. Malle, and R. Stocker. 1996. Presence of hypochlorite-modified proteins in human atherosclerosis. J. Clin. Invest. 97: 1535-1544.
7. Hazen, S. L., and J. W. Heinecke. 1997. 3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima. J. Clin. Invest. 99: 2075-2081.
8. Hoppe, G., A. Ravandi, D. Herrera, A. Kuksis, and H. F. Hoff. 1997. Oxidation products of cholesteryl linoleate are resistant to hydrolysis in macrophages, form complexes with proteins, and are present in human atherosclerotic lesions. J. Lipid Res. 38: 1347-1360.
9. Halliwell, B., and J. M. C. Gutteridge. 1989. Lipid peroxidation: a radical chain reaction. In Free Radicals in Biology and Medicine. 2nd ed. Clarendon Press, Oxford. 188-276.
10. Morel, D. W., P. E. Di Corlelto, and G. M. Chisolm. 1983. Low density lipoprotein cytotoxicity induced by free radical peroxidation of lipid. J. Lipid Res. 24: 1070-1076.
11. Iliou, J-P., C. Thollon, N. Villeneuve, F. Robin, C. Cambarrat, C. Jacquemin, and J-P. Vilaine. 1995. Monohydroperoxidized fatty acids but not 4-hydroxynonenal-induced acute cardiac cell damage. Free Radical Biol. Med. 19: 773-783.
12. Sasaguri, Y., N. Kakita, N. Murahashi, S. Kato, K. Hiraoka, M. Morimatsu, and K. Yagi. 1993. Effect of linoleic acid hydroperoxide on production of matrix metalloproteinases by human aortic endothelial and smooth muscle cells. Atherosclerosis. 100: 189-196.
13. Sattler, W., and R. Stocker. 1993. Greater selective uptake by HepG2 cells of high-density lipoprotein cholesteryl ester hydroperoxides than of unoxidized cholesteryl esters. Biochem. J. 294: 771-778.