Sodium-hydrogen exchange inhibition: Novel strategy to prevent myocardial injury following ischemia and reperfusion

American Journal of Cardiology

Volumn 83, Issue 10 A, 1999, Pages 19-22

  Buerke, Michael ^a   Rupprecht, Hans Jürgen ^a   Vom Dahl, Joachim ^b   Terres, Wolfram ^c   Seyfarth, Michael ^d   Schultheiss, Heinz Peter ^e   Richardt, Gert ^f   Sheehan, Florence H ^g   Drexler, Helmut ^h  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b RWTH AACHEN UNIVERSITY   (Germany)

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^d LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^e University Clinic   (Germany)

^f University Clinic   (Germany)

^g UNIVERSITY OF WASHINGTON   (United States)

^h University Clinic   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CARIPORIDE; CREATINE KINASE; LACTATE DEHYDROGENASE; PLACEBO;

ACUTE HEART INFARCTION; CALCIUM TRANSPORT; CATION EXCHANGE; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; HEART ARRHYTHMIA; HEART INFARCTION SIZE; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REPERFUSION INJURY; SIDE EFFECT; TRANSLUMINAL CORONARY ANGIOPLASTY; TREATMENT OUTCOME;

EID: 0033587082     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9149(99)00316-1     Document Type: Conference Paper

References (35)

1. Braunwald E., Kloner R.A. Myocardial reperfusion a double-edged sword? J Clin Invest. 76:1985;1713-1719.
2. Kloner RA, Ellis SG, Lange R, Braunwald E. Studies of experimental coronary artery reperfusion: effects on infarct size, myocardial function, biochemistry, ultrastructure and microvascular damage. Circulation 1983;68(suppl I):I-8-I-15.
3. Théroux P., Roy L. Coronary thrombolysis adjuvant medical therapy . Can J Cardiol. 9:1993;524-528.
4. Tsao P.S., Aoki N., Lefer D.J., Johnson G. III, Lefer A.M. Time course of endothelial dysfunction and myocardial injury during myocardial ischemia and reperfusion in the cat. Circulation. 82:1990;1402-1412.
5. Ma X.-L., Weyrich A.S., Lefer D.J., Lefer A.M. Diminished basal nitric oxide release after myocardial ischemia and reperfusion promotes neutrophil adherence to coronary endothelium. Circ Res. 72:1993;403-412.
6. Engler R.L., Dahlgren M.D., Morris D.D., Peterson M.A., Schmidt-Schonbein G.W. Role of leukocytes in response to acute myocardial ischemia and reflow in dogs. Am J Physiol. 251:1986;H314-H323.
7. Entman M.L., Smith C.W. Postreperfusion inflammation a model for reaction to injury in cardiovascular disease . Cardiovasc Res. 28:1994;1301-1311.
8. Farb A., Kolodgie F.D., Jenkins M., Virmani R. Myocardial infarct extension during reperfusion after coronary artery occlusion pathologic evidence . J Am Coll Cardiol. 21:1993;1245-1253.
9. Buerke M., Murohara T., Lefer A.M. Cardioprotective effects of a C1 esterase inhibitor in myocardial ischemia and reperfusion. Circulation. 91:1995;393-402.
10. Buerke M., Prüfer D., Dahm M., Oelert H., Meyer J., Darius H. Blocking of classical complement pathway inhibits endothelial adhesion molecule expression and preserves ischemic myocardium from reperfusion injury. J Pharmacol Exp Ther. 286:1998;429-438.
11. Weyrich A.S., Ma X.-L., Lefer D.J., Albertine K.H., Lefer A.M. In vivo neutralization of P-selectin protects feline heart and endothelium in myocardial ischemia and reperfusion injury. J Clin Invest. 91:1993;2620-2629.
12. Buerke M., Weyrich A.S., Zheng Z., Gaeta F.C., Forrest M.J., Lefer A.M. Sialyl Lewis-containing oligosaccharide attenuates myocardial reperfusion injury in cats. J Clin Invest. 93:1994;1140-1148.
13. Buerke M., Murohara T., Lefer A.M. Cardioprotective effect of insulin-like growth factor-1 in myocardial ischemia followed by reperfusion. Proc Natl Acad Sci USA. 92:1995;8031-8035.
14. Avkiran M., Ibuki C., Shimada Y., Haddock P.S. Effects of acidic reperfusion on arrhythmias and Na(+)-K(+)-ATPase activity in regionally ischemic rat hearts. Am J Physiol. 270:1996;H957-H964.
15. Lazdunski M., Frelin C., Vigne P. The sodium/hydrogen exchange system in cardiac cells its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH . J Mol Cell Cardiol. 17:1985;1029-1042.
16. +exchange . Am J Physiol. 265:1993;H2017-H2026.
17. +exchange and its inhibition in cardiac ischemia and reperfusion. Basic Res Cardiol. 88:1993;443-455.
18. concentration. J Biol Chem. 259:1984;8880-8885.
19. 2+ overload and impairs function in anoxic rat hearts. J Mol Cell Cardiol. 22:1990;57-72.
20. +exchange inhibitor and its effects in cardiac ischemia. Br J Pharmacol. 109:1993;562-568.
21. Meng H.-P., Maddaford T.G., Pierce G.N. Effect of amiloride and selected analogues on postischemic recovery of contractile function. Am J Physiol. 264:1993;H1831-H1835.
22. +antiporter isoforms using amiloride analogs and a new inhibitor exhibiting anti-ischemic properties. Mol Pharmacol. 44:1993;1041-1045.
23. 2+ overload in isolated perfused rabbit heart. Circulation. 89:1994;2787-2798.
24. +exchange . Am J Physiol. 255:1988;H608-H615.
25. + exchange inhibition in ischemic, reperfused porcine hearts. Circulation. 92:1995;912-917.
26. +exchange inhibitor reduces infarct size in pigs. Cardiovasc Res. 30:1995;945-951.
27. Sheehan F.H., Stewart D.K., Dodge H.T., Mitten S., Bolson E.L., Brown B.G. Variability in the measurement of regional left ventricular wall motion from contrast angiograms. Circulation. 68:1983;550-559.
28. +exchange inhibitor improves recovery of ventricular function in patients undergoing coronary angioplasty for acute anterior myocardial infarction. (Abstr.) Circulation 1998;98(suppl): I-344.
29. Entman M.L., Michael M., Rossen R.D., Deyer W.J., Anderson D.C., Taylor A.A., Smith C.W. Inflammation in the course of early myocardial ischemia. FASEB J. 5:1991;2529-2537.
30. Lefer A.M., Weyrich A.S., Buerke M. Role of selectins, a new family of adhesion molecules, in ischaemia-reperfusion injury. Cardiovasc Res. 28:1994;289-294.
31. Horstick G., Heimann A., Götze O., Hafner G., Berg O., Boehmer P., Becker P., Darius H., Rupprecht H.-J., Loos M., Bhakdi S., Meyer J., Kempski O. Intracoronary application of C1 esterase inhibitor improves cardiac function and reduces myocardial necrosis in an experimental model of ischemia and reperfusion. Circulation. 95:1997;701-708.
32. Weisman H.F., Bartow T., Leppo M.K., Marsh H.C., Carson G.R., Concino M.F., Boyle M.P., Roux K.H., Weisfeldt M.L., Fearson D.T. Soluble complement receptor type 1 in vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis . Science. 249:1991;146-151.
33. +exchange inhibitors in cardiovascular therapy. Cardiovasc Res. 29:1995;184-188.
34. + exchange inhibitor, Hoe 642 difference from preconditioning in the role of protein kinase C . J Am Coll Cardiol. 29:1997;693-701.
35. Bolli R. Myocardial "stunning" in man. Circulation. 86:1992;1671-1691.