The myocardial sodium-hydrogen exchanger (NHE) and its role in mediating ischemic and reperfusion injury

Keio Journal of Medicine

Volumn 47, Issue 2, 1998, Pages 65-72

  Karmazyn, Morris ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Cardioprotection; Heart; Myocardial ischemia; Na hydrogen exchange; Reperfusion

Indexed keywords

(3 METHYLSULFONYL 4 PIPERIDINOBENZOYL)GUANIDINE METHANESULFONATE; ADENOSINE TRIPHOSPHATASE; AMILORIDE; ANTIPORTER; CALCIUM ION; CARIPORIDE; PROTON; SODIUM ION; UNCLASSIFIED DRUG;

CELL PH; CELL PROTECTION; CLINICAL TRIAL; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; HUMAN; NONHUMAN; OXIDATIVE STRESS; PROTON SODIUM EXCHANGE; REPERFUSION INJURY; REVIEW;

EID: 0031902064     PISSN: 00229717     EISSN: None     Source Type: Journal    
DOI: 10.2302/kjm.47.65     Document Type: Review

References (56)

1. Orchard CH, Kentish JC: Effects of changes of pH on the contractile function of cardiac muscle. Am J Physiol 1990; 258: C967-C981
2. Wakabayashi S, Shigekawa M, Pouysségur J: Molecular physiology of vertebrate Na+/H+ exchangers. Physiol Rev 1997; 77: 51-74
3. + exchanger gene family: structure and function studies. Am J Physiol 1995; 269: G1-G11
4. + exchange in cardiac physiology and pathophysiology: mediation of myocardial reperfusion injury by the pH paradox. Cardiovasc Res 1993; 27: 915-924
5. Kleyman TR, Cragoe EJ Jr: Amiloride and its analogs as tools in the study of ion transport. J Membr Biol 1988; 105: 1-21
6. Scholz W, Albus U, Counillon L, Gögelein H, Lang H-J, Linz W, Weichert A, Schölkens BA: Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion. Cardiovasc Res 1995; 29: 260-268
7. + concentration. A molecular basis for the antagonistic effect of ouabain and amiloride on the heart. J Biol Chem 1984; 259: 8880-8885
8. Kim D, Smith TW: Effects of amiloride and ouabain on contractile state, Ca and Na fluxes, and Na content in cultured chick heart cells. Mol Pharmacol 1986; 29: 363-371
9. Finet M, Godfraind T: Selective inhibition by ethylisopropylamiloride of the positive inotropic effect evoked by low concentrations of ouabain in rat isolated ventricles. Br J Pharmacol 1986; 89: 533-538
10. Lazdunski M, Frelin C, Vigne P: The sodium/hydrogen exchange system in cardiac cells: its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH. J Mol Cell Cardiol 1985; 17: 1029-1042
11. Frelin C, Vigne P, Ladoux A, Lazdunski M: The regulation of the intracellular pH in cells from vertebrates. Eur J Biochem 1988; 174: 3-14
12. Piwnica-Worms D, Jacob R, Shigeto N, Horres CR, Lieberman M: Na/H exchange in cultured heart cells: secondary stimulation of electrogenic transport during recovery from intracellular acidosis. J Mol Cell Cardiol 1986; 18: 1109-1116
13. Kim D, Cragoe EJ Jr, Smith TW: Relations among sodium pump inhibition, Na-Ca and Na-H exchange activities, and Ca-H interaction in cultured chick heart cells. Circ Res 1987; 60: 185-193
14. 2+ influx. FEBS Lett 1989; 259: 1-4
15. Piwnica-Worms D, Jacob R, Horres CR, Lieberman M: Na/H exchange in cultured chick heart cells. J Gen Physiol 1985; 85: 43-64
16. i. Adv Exp Med Biol 1992; 311: 435-436
17. Koike A, Akita T, Hotta Y, Takeya K, Kodama I, Murase M, Abe T, Toyama J: Protective effects of dimethyl amiloride against postischemic myocardial dysfunction in rabbit hearts: phosphorus 31-nuclear magnetic resonance measurements of intracellular pH and cellular energy. J Thorac Cardiovasc Surg 1996; 112: 765-775
18. + exchange on intracellular sodium and pH in working and ischemic hearts. Magn Reson Med 1994; 32: 556-564
19. + exchange attenuates neutrophil-mediated reperfusion injury. Ann Thorac Surg 1995; 60: 377-381
20. Karmazyn, M: The role of endothelins in cardiac function in health and disease. In: Karmazyn, M, ed. Myocardial ischemia: mechanisms, reperfusion, protection. Birkhauser Verlag. Basel, 1996, pp 209-230
21. + exchange in mediating effects of endothelin-1 on normal and ischemic/reperfused hearts. Circ Res 1994; 75: 369-378
22. 1 adrenergic stimulation: a potential role for receptor mediated activation of sarcolemmal sodium-hydrogen exchange. Cardiovasc Res 1995; 29: 222-230
23. Neely JR, Grotyohann LW: Role of glycolytic products in damage to ischemic myocardium. Dissociation of adenosine triphosphate levels and recovery of function of reperfused ischemic hearts. Circ Res 1984; 55: 816-824
24. Cross HR, Clarke K, Opie LH, Radda GK: Is lactate-induced myocardial ischaemic injury mediated by decreased pH or increased intracellular lactate? J Mol Cell Cardiol 1995; 27: 1369-1381
25. 2+ exchange. Circ Res 1989; 65: 1045-1056
26. + exchange inhibitors reverse lactate-induced depression in postischaemic ventricular recovery. Br J Pharmacol 1993; 108: 50-56
27. + exchange inhibition protects against mechanical, ultrastructural and biochemical impairment induced by low concentrations of lysophosophatidylcholine in isolated rat hearts. Circ Res 1997; 80: 95-102
28. Hoque AN, Karmazyn M: Effect of sodium-hydrogen exchange inhibition on functional and metabolic impairment produced by oxidative stress in the isolated rat heart. Can J Physiol Pharmacol 1997; 75: 326-334
29. + exchange. Am J Physiol 1988; 255: H608-H615
30. Duan J, Karmazyn M: Protective effects of amiloride on the ischemic reperfused rat heart. Relation to mitochondrial function. Eur J Pharmacol 1993; 210: 149-157
31. + exchange inhibitor in cardiac ischaemia. Br J Pharmacol 1993; 109: 562-568
32. 2+ overload in isolated perfused rabbit heart. Circulation 1994; 89: 2787-2798
33. + exchange inhibition in ischemic, reperfused porcine hearts. Circulation 1995; 92: 912-917
34. + exchange inhibitor, on ventricular arrhythmias in animal hearts. Eur J Pharmacol 1996; 317: 309-316
35. + antiporter inhibitor on postischemic reperfusion in pig heart. J Cardiovasc Pharmacol 1994; 23: 72-78
36. + exchange and reperfusion arrhythmias: protection by intracoronary infusion of a novel inhibitor. Am J Physiol 1994; 267: H2430-H2440
37. + exchanger inhibitors. Am J Physiol 1996; 270: H692-700
38. + exchange inhibitor, Hoe 642: Difference from preconditioning in the role of protein kinase C. J Am Coll Cardiol 1997; 29: 693-701
39. Moffat MP, Karmazyn M: Protective effects of the potent Na/H exchange inhibitor methylisobutyl amiloride against post-ischemic contractile dysfunction in rat and guinea-pig hearts. J Mol Cell Cardiol 1993; 25: 959-971
40. Meng HP, Pierce GN: Protective effects of 5-(N,N-dimethyl) amiloride on ischemia-reperfusion injury in hearts. Am J Physiol 1990; 258: H1615-H1619
41. Meng HP, Maddaford TG, Pierce GN: Effect of amiloride and selected analogues on postischemic recovery of cardiac contractile function. Am J Physiol 1993; 264: H1831-H1835
42. Anderson SE, Murphy E, Steenbergen C, London RE, Cala PM: Na-H exchange in myocardium: effects of hypoxia and acidification on Na and Ca. Am J Physiol 1990; 259: C940-C948
43. Murphy E, Perlman M, London RE, Steenbergen C: Amiloride delays the ischemia-induced rise in cytosolic calcium. Circ Res 1991; 68: 1250-1258
44. 2+ in the reperfusate and protective effects of amiloride added to the cardioplegic solution. Heart Vessels 1995; 10: 310-317
45. Karwatowska-Prokopczuk E, Czarnowska E, Prokopczuk A: Combined therapy with dimethyliourea, diltiazem and amiloride/dimethylamiloride in the ischemic/reperfused heart. Cardiovasc Res 1995; 30: 70-78
46. Mathur S, Karmazyn M: Interaction between anesthetics and the sodium-hydrogen exchange inhibitor 642 (cariporide) in ischemic and reperfused rat hearts. Anesthesiology, 1997; 87: 1460-1469
47. Karmazyn M, Bend JR: Molecular and biochemical mechanisms of myocardial injury. In: Bishop SP, ed. Volume 6, Comprehensive Toxicology (Cardiovascular Toxicology), Amsterdam, Elsevier Science, 1997, pp 255-278
48. Gottlieb RA, Gruol DL, Zhu JY, Engler RL: Preconditioning in rabbit cardiomyocytes. Role of pH, vacuolar proton ATPase, and apoptosis. J Clin Invest 1996; 97: 2391-2398
49. Chakrabarti S, Hoque ANE, Karmazyn M: A rapid ischemia-induced apoptosis in isolated rat hearts and its attenuation by the sodium-hydrogen exchange inhibitor HOE 642 (Cariporide). J Mol Cell Cardiol, 1997; 29: 3169-3174
50. + exchange inhibitor HOE 694. Ann Thorac Surg 1996; 61: 1400-1406
51. 31P NMR study in isolated pig hearts. J Mol Cell Cardiol 1995; 27: 2237-2248
52. + exchange blocker amiloride on left ventricular remodeling after anterior myocardial infarction in rats. Cardiovasc Drugs Ther 1995; 9: 823-826
53. + exchange blocker, in a murine model of dilated cardiomyopathy. Res Commun Mol Pathol Pharmacol 1996; 92: 201-210
54. Allard MF, Lopaschuk GD: Ischemia and reperfusion injury in the hypertrophied heart. In: Karmazyn M, ed, Myocardial ischemia: mechanisms, reperfusion, protection. Basel, Birkhäuser, 1996: pp 423-411
55. + buffering capacity in normal and hypertrophied right ventricle of ferret heart. Cardiovasc Res 1996; 31: 729-738
56. + exchange in impaired in cardiac hypertrophy. J Clin Invest 1997; 99: 125-135