Erythrocyte membrane transport physiology

Current Opinion in Hematology

Volumn 4, Issue 2, 1997, Pages 122-127

  Brugnara, Carlo ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLOTRIMAZOLE; INSULIN; PYROGLUTAMATE MAGNESIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANION EXCHANGE; BLOOD PRESSURE; CALCIUM TRANSPORT; CELL MEMBRANE TRANSPORT; CHLORIDE TRANSPORT; CYTOSKELETON; DIABETIC NEPHROPATHY; ERYTHROCYTE MEMBRANE; ESSENTIAL HYPERTENSION; HEMOLYSIS; HUMAN; HUMAN CELL; MOUSE; MUTAGENESIS; NONHUMAN; PHYSIOLOGY; POTASSIUM TRANSPORT; PRIORITY JOURNAL; PROTON TRANSPORT; SHORT SURVEY; SICKLE CELL; SODIUM TRANSPORT; TRANSGENIC MOUSE;

EID: 0030920958     PISSN: 10656251     EISSN: None     Source Type: Journal    
DOI: 10.1097/00062752-199704020-00008     Document Type: Short Survey

References (70)

1. Pedersen PI, Carafoli E: Ion motive ATPases. I. Ubiquity, properties and significance to cell function. Trends Biochem Sci 1987, 12:146-150.
2. Shull GE, Schwarte A, Lingrel, JB: Amino-acid sequence of the catalytic subunit of the (Na+-K+)ATPase deduced from a complementary DNA. Nature 1985, 316:691-695.
3. Shull GE, Greeb J, Lingrel JB: Molecular cloning of three distinct forms of the Na+,K+-ATPase α-subunit from rat brain. Biochemistry 1986, 25:8125-8132.
4. Young RM, Shull GE, Lingrel JB: Multiple mRNAs from rat kidney and brain encode a single Na+,K+-ATPase β subunit protein. J Biol Chem 1987, 262:4905-4910.
5. Martin-Vasallo P, Dackowski W, Emanuel JR, Levenson R: Identification of a putative isoform of the Na,K-ATPase ß subunit. J Biol Chem 1989, 264:4613-4618.
6. Erdmann E, Hasse W: Quantitative aspects of ouabain binding to human erythrocyte and cardiac membranes. J Physiol 1975, 251:671-682.
7. Joiner CH, Lauf PK: Ouabain binding and potassium transport in young and old populations of human red cells. Membr Biochem 1978, 1:187-202.
8. Tosteson DC, Hoffman JF: Regulation of cell volume by active cation transport in high and low potassium sheep red cells. J Gen Physiol 1960,44:169-194.
9. + pump in human red cells with increased number of pump sites. J Clin Invest 1987, 80:128-137.
10. 2+ pump. J Biol Chem 1988, 263:14152-14159.
11. Strehler EE, James P, Fisher R, Heim R, Vorherr T, Filoteo AG, Penniston JF, Carafoli E: Peptide sequence analysis and molecular cloning reveal two calcium pump isoforms in the human erythrocyte membrane. J Biol Chem 1990, 265:2835-2842.
12. 2+ levels of sickle cell anemia red cells. J Clin Invest 1993, 92:2489-2498.
13. Wiley JS, Cooper RA: A furosemide-sensitive cotransport of sodium plus potassium in the human red cell. J Clin Invest 1974, 53:745-755.
14. Haas M: Properties and diversity of (Na-K-CI) cotransporters. Annu Rev Physiol 1989, 51:443-457.
15. Xu JC, Lytle C, Zhu T, Payne JA, Benz E, Forbush B III: Molecular cloning and functional expression of the bumetanide-sensitive Na-K-Cl cotransporter. J Biol Chem 1994, 91:2201-2205.
16. +-Cl-cotransporter from mouse inner medullary collecting duct (mIMCD-3) cells. J Biol Chem 1994, 269:25677-25683.
17. Brugnara C, Canessa M, Cusi D, Tosteson DC: Furosemide-sensitive Na and K fluxes in human red cells. Net uphill Na extrusion and equilibrium properties. J Gen Physiol 1986, 87:91-112.
18. Lauf PK, Bauer J, Adragna NC, Fujise H, Zade-Oppen AM, Ryu KH, Delpire E: Erythrocyte K-Cl cotransport: properties and regulation. Am J Physiol (Cell Physiol) 1992, 263:C917-C932.
19. Brugnara C, Kopin AK, Bunn HF, Tosteson DC: Regulation of cation content and cell volume in erythrocytes from patients with homozygous hemoglobin C disease. J Clin Invest 1985, 75:1608-1617.
20. Brugnara C, Bunn HF, Tosteson DC: Regulation of erythrocyte cation and water content in sickle cell anemia. Science 1986, 232:388-390.
21. Canessa M, Spalvin A, Nagel RL: Volume-dependent and NEM-stimulated K+,Cl- transport is elevated in SS, SC and CC human red cells. FEBS Lett 1986, 200:197-202.
22. Canessa M, Fabry ME, Blumenfeld N, Nagel RL: Volume-stimulated, Cl-dependent K+ efflux is highly expressed in young human red cells containing normal hemoglobin or HbS. J Membr Biol 1987, 97:97-105.
23. Brugnara C, Tosteson DC: Cell volume, K transport and cell density in human erythrocytes. Am J Physiol (Cell Physiol 21) 1987, 252:C269-C276.
24. Brugnara C, Tosteson DC: Inhibition of K transport by divalent cations in sickle erythrocytes. Blood 1987, 70:1810-1815.
25. Gillen CM, Brill SB, Payne JA, Forbush B: Molecular cloning and functional expression of the K-CL cotransporter from rabbit, rat and human. J Biol Chem 1996, 271:16237-16244. This paper provides the first molecular identification of the K-Cl cotransport system and the localization of its genomic sequence to 16q22.1
26. Payne JA, Stevenson TJ, Donaldson LF: Molecular characterization of a putative K-Cl cotransporter in rat brain. J Biol Chem 1996, 271:16245-16252. Molecular identification of the brain K-Cl cotransport system, an important determinant of cell volume and of the low cell Cl content of neurons.
27. Joiner CH: Cation transport and volume regulation in sickle red blood cells. Am J Physiol (Cell Physiol 33) 1993, 264:C251-C270.
28. Eaton WA, Hofrichter J: Hemoglobin S gelation and sickle cell disease. Blood 1987, 70:1245-1266.
29. Brugnara C, Van Ha T, Tosteson DC: Acid pH induces formation of dense cells In sickle erythrocytes. Blood 1989, 74:487-495.
30. Franco RS, Palascak M, Thompson H, Joiner CH: KCI cotransport activity in light versus dense transferrin receptor-positive sickle reticulocytes. J Clin Invest 1995, 95:2573-2580.
31. Fathallah H, Coezy E, de Neef RS, Hardy-Dessources MD, Giraud F: Inhibition of deoxygenation-induced membrane protein dephosphorylation and cell dehydration by phorbol esters and okadaic acid in sickle cells. Blood 1995, 86:1999-2007.
32. Franco RS, Palascak M, Thompson H, Rucknagel DK, Joiner CH: Dehydration of transferrin receptor-positive sickle reticulocytes during continuous or cyclic deoxygenation: role of KCI cotransport and extracellular Ca. Blood 1996, 88:4359-4365.
33. De Franceschi L, Beuzard Y, Brugnara C: Sulphydryl oxidation and activation of red cell K-CI cotransport in the transgenic SAD mouse. Am J Physiol (Cell Physiol 38) 1995, 260:C899-C906.
34. De Franceschi L, Beuzard Y, Jouault H, Brugnara C: Modulation of erythrocyte potassium-chloride cotransport, potassium content and density by dietary magnesium intake in transgenic SAD mouse. Blood 1996, 88:2738-2744. First in vivo demonstration in a transgenic mouse model of sickle cell disease of the beneficial effect of inhibition of K-Cl cotransport with dietary Mg supplements.
35. De Franceschi L, Bachir D, Galacteros F, Tchernia GJ, Cynober T, Alper SL, Beuzard Y, Brugnara C: Reduction of K-Cl cotransport-mediated erythrocyte dehydration by dietary magnesium supplements in patients with sickle cell disease [abstract]. Blood 1996, 88(S1):648a. First demonstration in patients with sickle cell disease that dietary Mg supplements induce a reduction in the dehydration of sickle erythrocytes.
36. + fluxes in human red cells: amiloride sensitivity. J Biol Chem 1985, 260:11914-11923.
37. + transport in human red cells: evidence for a Na/H exchange system. J Membr Biol 1986, 90:21-28.
38. + exchange of rabbit red cells: evidence for a common pathway. J Membr Biol 1990, 118:193-214.
39. + exchange is increased in sickle cell anemia and young normal red cells. J Membr Biol 1990, 116:107-115.
40. + antiporter. Cell 1989, 56:271-280.
41. + antiporter cDNAs from human tissues. Am J Physiol (Cell Physiol 31) 1992, 262:C1069-C1076.
42. Zerbini G, Ceolotto G, Gaboury C, Mos L, Pessina AC, Canessa M, Semplicini A: Sodium-lithium countertransport has low affinity for sodium in hyperinsulinemic hypertensive patients. Hypertension 1995, 25:986-993. This report demonstrated the effects of insulin on the erythrocyte Na-Li counter-transport. Abnormalities in Na-Li countertransport in hypertensive patients can be correlated to increased insulin levels (low affinity for external Na) and to increased blood pressure (increased maximal rate of Na-Li countertransport).
43. Falkner B, Kushner H, Levison S, Canessa M: Albuminuria in association with insulin and sodium-lithium countertransport in young African Americans with borderline hypertension. Hypertension 1995, 25:1315-1321. This study identifies correlations between erythrocyte Na-Li countertransport, albuminuria, and insulin resistance in a group of young blacks with borderline hypertension.
44. Tanner MJ, Martin PG, Hisg S: The complete amino acid sequence of the human erythrocyte membrane anion transport protein deduced from the cDNA sequence. Biochem J 1988, 256:703-712.
45. Lux S, John K, Kopito R, Lodish HF: Cloning and characterization of band 3, the human erythrocyte anion exchange protein (AE1). Proc Natl Acad Sci U S A 1989, 86:9089-9093.
46. Alper SL: The band 3-related anion exchanger (AE) gene family. Annu Rev Physiol 1991, 53:549-564.
47. Jennings ML: Cellular anion transport. In The Kidney: Physiology and Pathophysiology, edn 2. Edited by Seldin DW, Giebish G. New York: Raven Press; 1992:113-145.
48. Jarolim P, Rubin HL, Liu S, Cho MR, Brabec V, Derrick LH, Yi S, Saad ST, Alper SL, Brugnara C, Golan D, Palek J: Duplication of 10 nucleotides in the erythroid band 3 (AE1) gene in a kindred with hereditary spherocytosis and band 3 protein deficiency (Band 3 Prague). J Clin Invest 1994, 93:121-130.
49. Jarolim P, Rubin HL, Brabec V, Chrobak L, Zolatarev AS, Alper SL, Brugnara C, Wichterle H, Palek J: Mutations of conserved arginines in the membrane domain of erythrocyte band 3 lead to a decrease in membrane-associated band 3 and to the phenotype of hereditary spherocytosis. Blood 1995, 85:634-640.
50. Peters LL, Shivdasani RA, Liu SC, Hanspal M, John K, Gonzales J, Brugnara C, Gwynn B, Mohandas N, Alper SL, Orkin S, Lux SE: Anion exchanger 1 (band 3) is required to prevent erythrocyte membrane surface loss but not to form the membrane skeleton. Cell 1996, 86:917-927. First evidence that absence of the anion exchanger is not incompatible with life. Mice deficient in band 3 have profound anemia and reduced perinatal survival, normal cytoskeletal assembly, and markedly reduced membrane stability.
51. Gardos G: The function of calcium in the potassium permeability of human erythrocytes. Biochim Biophys Acta 1958, 30:653-654.
52. + transport of human and rabbit erythrocytes: comparison of binding and transport inhibition by scorpion toxins. J Biol Chem 1993, 268:8760-8768.
53. Alvarez J, Montero M, Garcia-Sancho J: High affinity inhibition of Ca2+-dependent K+ channels by cytochrome P-450 inhibitors. J Biol Chem 1992, 267:11789-11793.
54. + transport and cell dehydration in sickle erythrocytes by clotrimazole and other imidazole derivatives. J Clin Invest 1993, 92:520-526.
55. Romero PJ, Ortiz CE, Melitto C: Metabolic control of the K+ channel of human red cells. J Membr Biol 1990, 116:19-29.
56. Köhler M, Hirschberg B, Bond CT, Kinzie JM, Marrion NV, Maylie J, Adelman JP: Small-conductance, calcium-activated potassium channels from mammalian brain. Science 1996, 273:1709-1714. This paper presents the first molecular identification of the small conductance Ca-activated K channels, which play a crucial role in hyperpolanzation in neurons, and have features similar to those of the human erythrocyte Gardos channel.
57. + efflux limits complement mediated lysis of human erythrocytes. J Clin Invest 1989, 83:1466-1471.
58. Lew VL, Bookchin RB: Volume, pH and ion-content regulation in human red cells: analysis of transient behavior with an integrated model. J Membr Biol 1986, 92:57-74.
59. Lew VL, Freeman CJ, Ortiz OE, Bookchin RM: A mathematical model of the volume, pH and ion content regulation in reticulocytes. J Clin Invest 1991, 87:100-112.
60. +-permeabilized human red cells lose an alkaline, hypertonic fluid containing excess K over diffusible anions. J Membr Biol 1987, 96:235-241.
61. Bookchin RM, Ortiz OE, Lew VL: Evidence for a direct reticulocyte origin of dense red cells in sickle cell anemia. J Clin Invest 1991, 87:113-124.
62. + transport and reverses erythrocyte dehydration in transgenic SAD mice: a model for therapy of sickle cell disease. J Clin Invest 1994, 93:1670-1676.
63. Brugnara C, Gee B, Armsby C, Kurth S, Sakamoto M, Rifai N, Alper SL, Platt OS: Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease. J Clin Invest 1996, 97:1227-1234. This study provides in vivo evidence for the role of the Gardos channel in promoting dehydration of sickle erythrocytes. It also demonstrates the efficacy of oral administration of clotrimazole in preventing sickle cell dehydration.
64. + channel: the imidazole ring is not required for inhibitory activity. J Pharmacol Exp Ther 1995, 273:266-272. This study demonstrates the activity of clotrimazole metabolites in inhibiting the erythrocyte Gardos channel. Because these compounds are nonactive as inhibitors of cytochrome P450, it also demonstrates that this system is not involved in the regulation of the activity of the human erythrocyte Gardos channel.
65. Rifai N, Sakamoto M, Law T, Platt O, Mikati M, Armsby CC, Brugnara C: Measurement by HPLC, blood distribution and pharmacokinetics of oral clotrimazole, a new potential antisickling agent Clim Chem 1995, 41:387-391.
66. Halperin JA, Brugnara C, Tosteson MT, Van Ha T, Tosteson DC: Voltage activated cation transport in human erythrocytes. Am J Physiol (Cell Physiol 26) 1989, 257:C986-C996.
67. Christophersen P, Bennekou P: Evidence for a voltage-gated, nonselective cation channel in the human red cell membrane. Biochim Biophys Acta 1991, 1065:103-106.
68. Halperin JA, Cornelius F: A voltage-activated cation transport pathway associated with the sodium pump. Biochim Biophys Acta 1991, 1070:497-500.
69. Macey R: Transport of water and urea in red blood cells. Am J Physiol (Cell Physiol 15) 1984, 246:C195-C203.
70. Preston GM, Carrol TP, Guggino WB, Agre P: Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein. Science 1992, 256:385-387.