Depletion of Phosphatidylinositol 4,5-Bisphosphate by Activation of Phospholipase C-coupled Receptors Causes Slow Inhibition but Not Desensitization of G Protein-gated Inward Rectifier K+ Current in Atrial Myocytes

Journal of Biological Chemistry

Volumn 276, Issue 8, 2001, Pages 5650-5658

  Meyer, Thomas ^a   Wellner Kienitz, Marie Cécile ^a   Biewald, Anke ^a   Bender, Kirsten ^a   Eickel, Andreas ^a   Pott, Lutz ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; HORMONES; PROTEINS;

FAST DESENSITIZATION;

PHOSPHOLIPIDS;

ACETYLCHOLINE; ALPHA ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; ENDOTHELIN RECEPTOR; ENDOTHELIN RECEPTOR AGONIST; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); INWARDLY RECTIFYING POTASSIUM CHANNEL; MUSCARINIC M3 RECEPTOR; MUSCARINIC M3 RECEPTOR ANTAGONIST; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOLIPASE C; 4 DIPHENYLACETOXY 1,1 DIMETHYLPIPERIDINIUM; 4-DIPHENYLACETOXY-1,1-DIMETHYLPIPERIDINIUM; CELL SURFACE RECEPTOR; ENDOTHELIN 1; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; PHENYLEPHRINE; PIPERIDINE DERIVATIVE; POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DESENSITIZATION; DRUG ACTIVITY; HEART ATRIUM MUSCLE; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; RECEPTOR INTRINSIC ACTIVITY; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; CHANNEL GATING; CYTOLOGY; ELECTRIC CONDUCTIVITY; HEART ATRIUM; METABOLISM;

ANIMALIA;

ACETYLCHOLINE; ELECTRIC CONDUCTIVITY; ENDOTHELIN-1; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HEART ATRIA; ION CHANNEL GATING; MUSCARINIC ANTAGONISTS; PHENYLEPHRINE; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHOLIPASE C; PIPERIDINES; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RECEPTORS, CELL SURFACE; RECEPTORS, ENDOTHELIN; RECEPTORS, MUSCARINIC;

EID: 0035937119     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M009179200     Document Type: Article

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