ATP-dependent desensitization of the muscarinic K+ channel in rat atrial cells

Journal of Physiology

Volumn 505, Issue 1, 1997, Pages 77-93

  Shui, Z ^a   Boyett, M R ^a   Zang, W J ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE DERIVATIVE; CHOLINERGIC RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); GUANOSINE TRIPHOSPHATE; MUSCARINIC RECEPTOR; POTASSIUM CHANNEL; ADENOSINE PHOSPHATE; MUSCARINIC POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DEPHOSPHORYLATION; DESENSITIZATION; HEART ATRIUM; HEART MUSCLE CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; ATRIAL CELL; FAST DESENSITIZATION; INSIDE OUT PATCH CLAMP; OUTSIDE OUT PATCH CLAMP; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM;

EID: 0030829227     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1997.077bc.x     Document Type: Article

References (28)

1. 1 subfamily of G protein α-subunits. Cell 86, 445-452.
2. BOYETT, M. R., KIRBY, M. S., ORCHARD, C. H. & ROBERTS, A. (1988). The negative inotropic effect of acetylcholine on ferret ventricular myocardium. Journal of Physiology 404, 613-635.
3. BOYETT, M. R., KODAMA, I., HONJO, H., ARAI, A., SUZUKI, R. & TOYAMA, J. (1995). Ionic basis of the chronotropic effect of acetylcholine on the rabbit sinoatrial node. Cardiovascular Research 29, 867-878.
4. BOYETT, M. R. & ROBERTS, A. (1987). The fade of the response to acetylcholine at the rabbit isolated sino-atrial node. Journal of Physiology 393, 171-194.
5. K(Ach). Journal of Physiology 480, 91P.
6. + channels in the absence of agonist and G-nucleotides. Pflügers Archiv 416, 213-215.
7. + channels by nucleoside triphosphates in the absence of acetylcholine. Journal of Cardiovascular Electrophysiology 3, 457-473.
8. + channel activity in guinea-pig atrial cells is supported by nucleoside diphosphate kinase. Pflügers Archiv 422, 316-324.
9. + channel activity by a cytosolic protein via G protein-independent pathway. American Journal of Physiology 270, H526-537.
10. HONJO, H., KODAMA, I. & TOYAMA, J. (1994). Suppression of muscarinic potassium channel activation by intracellular ATP depletion. Environmental Medicine 38, 53-56.
11. HONJO, H., KODAMA, I., ZANG, W.-J. & BOYETT, M. R. (1992). Desensitization to acetylcholine in single sino-atrial node cells isolated from the rabbit heart. American Journal of Physiology 263, H1779-1789.
12. + channels in rabbit atrium. Journal of Physiology 433, 589-613.
13. KAKEI, M., NOMA, A. & SHIBASAKI, T. (1985). Properties of adenosine-triphosphate-regulated potassium channels in guinea-pig ventricular cells. Journal of Physiology 363, 441-462.
14. + channel via cyclic AMP-dependent protein kinase in atrial cells. Circulation Research 67, 1292-1298.
15. + channel function in rat atrial cells by phosphorylation. Journal of Physiology 437, 133-155.
16. + current in adult rat and guinea-pig atrial cells. Circulation Research 73, 89-97.
17. +-channel proteins. Nature 374, 135-141.
18. KUBO, Y., REUVENY, E., SLESINGER, P. A., JAN, Y. N. & JAN, L. Y. (1993). Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channel. Nature 364, 802-806.
19. MARTIN, P., LEVY, M. N. & MATSUDA, Y. (1982). Fade of cardiac responses during tonic vagal stimulation. American Journal of Physiology 243, H219-225.
20. MUBAGWA, K. & CARMELIET, E. (1983). Effects of acetylcholine on electrophysiological properties of rabbit cardiac Purkinje fibers. Circulation Research 53, 740-751.
21. REUVENY, E., SLESINGER, P. A., INGLESE, J., MORALES, J. M., INIGUEZ-LLUHI, J. A., LEFKOWITZ, R. J., BOURNE, H. R., JAN, Y. N. & JAN, L. Y. (1994). Activation of the cloned muscarinic potassium channel by G protein βγ subunits. Nature 370, 143-146.
22. + channel in rat atrial cells - dependence of intracellular ATP. Journal of Physiology 487.P, 129-130P.
23. + current in rat atrial cells. Journal of Physiology 487, 359-366.
24. TEN EICK, R., NAWRATH, H., MCDONALD, T. F. & TRAUTWEIN, W. (1976). On the mechanism of the negative inotropic effect of acetylcholine. Pflügers Archiv 361, 207-213.
25. TRAUTWEIN, W. & HESCHELER, J. (1990). Regulation of cardiac L-type calcium current by phosphorylation and G proteins. Annual Review of Physiology 52, 257-274.
26. + current in cat atrial myocytes. American Journal of Physiology 268, H1313-1321.
27. WATSON, N., LINDER, M. E., DRUEY, K. M., KEHRL, J. H. & BLUMER, K. J. (1996). RGS family members: GTPase activating proteins for heterotrimeric G-protein α-subunits. Nature 383, 172-177.
28. ZANG, W.-J., YU, X.-J., HONJO, H., KIRBY, M. S. & BOYETT, M. R. (1993). On the role of G protein activation and phosphorylation in desensitization to acetylcholine in guinea-pig atrial cells. Journal of Physiology 464, 649-679.