Human Glutathione Transferase T2-2 Discloses Some Evolutionary Strategies for Optimization of the Catalytic Activity of Glutathione Transferases

Journal of Biological Chemistry

Volumn 276, Issue 8, 2001, Pages 5432-5437

  Caccuri, Anna Maria ^a   Antonini, Giovanni ^b,c   Board, Philip G ^d   Flanagan, Jack ^d   Parker, Michael W ^e   Paolesse, Roberto ^a   Turella, Paola ^a,c   Chelvanayagam, Gareth ^d   Ricci, Giorgio ^a,f  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY OF L'AQUILA   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d Biology and Environment   (Australia)

^e ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^f BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; DIMERS; ENZYMES; MUTAGENESIS; PH EFFECTS; SUBSTRATES;

RANDOM KINETIC MECHANISM;

BIOCHEMISTRY;

1 MENAPHTHYL SULFATE; ALANINE; ARGININE; ENZYME PRECURSOR; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE T2 2; SULFATE; UNCLASSIFIED DRUG; GLUTATHIONE; GSTT2 PROTEIN, HUMAN; ISOENZYME; PROTON; THIOL DERIVATIVE;

ARTICLE; CATALYSIS; ENZYME BINDING; ENZYME KINETICS; ENZYME MECHANISM; ENZYME RELEASE; MOLECULAR EVOLUTION; PRIORITY JOURNAL; PROTON TRANSPORT; SITE DIRECTED MUTAGENESIS; STEADY STATE; CHEMICAL MODEL; CLASSIFICATION; COMPARATIVE STUDY; ENZYME ACTIVE SITE; FLOW INJECTION ANALYSIS; GENETICS; HUMAN; KINETICS; METABOLISM; MUTATION; PH;

FELIS CATUS;

ARGININE; CATALYTIC DOMAIN; EVOLUTION, MOLECULAR; FLOW INJECTION ANALYSIS; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HUMANS; HYDROGEN-ION CONCENTRATION; ISOENZYMES; KINETICS; MODELS, CHEMICAL; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTONS; SULFHYDRYL COMPOUNDS;

EID: 0035937105     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M002818200     Document Type: Article

References (32)

1. Pemble, S. E., and Taylor, J. B. (1992) Biochem. J. 287, 957-963
2. Pemble, S. E., Wardle, A. F., and Taylor, J. B. (1996) Biochem. J. 319, 749-754
3. Armstrong, R. N. (1997) Chem. Res. Toxicol. 10, 2-18
4. Salinas, A. E., and Wong, M. G. (1999) Curr. Med. Chem. 6, 279-309
5. Board, P. G., Baker, R. T., Chelvanayagam, G., and Jermiin, L. S. (1997) Biochem. J. 328, 929-935
6. Dirr, H. W., Reinemer, P., and Huber, R. (1994) Eur. J. Biochem. 220, 645-661
7. Wilce, M. C. J., and Parker, M. W. (1994) Biochim. Biophys. Acta 1205, 1-18
8. Rossjohn, J., McKinstry, W. J., Oakley, A. J., Verger, D., Flanagan, J., Chelvanayagam, G., Tan, K.-L., Board, P. G., and Parker, M. W. (1997) Structure 6, 309-322
9. Wilce, M. C. J., Board, P. G., Feil, S. C., and Parker, M. W. (1995) EMBO J. 14, 2133-2143
10. Caccuri, A. M., Antonini, G., Board, P. G., Flanagan, J., Parker, M. W., Paolesse, R., Turella, P., Federici, G., Lo Bello, M., and Ricci, G. (2001) J. Biol. Chem. 276, 5427-5431
11. Caccuri, A. M., Lo Bello, M., Nuccetelli, M., Nicotra, M., Rossi, P., Antonini, G., Federici, G., and Ricci, G. (1998) Biochemistry 37, 3028-3034
12. Caccuri, A. M., Antonini, G., Board, P. G., Parker, M. W., Nicotra, M., Lo Bello, M., Federici, G., and Ricci, G. (1999) Biochem. J. 344, 419-425
13. Tan, K.-L., Chelvanayagam, G., Parker, M. W., and Board, P. G. (1996) Biochem. J. 319, 315-321
14. Jemth, P., and Mannervik, B. (1999) Biochemistry 36, 9982-9991
15. Jemth, P., and Mannervik, B. (2000) J. Biol. Chem. 275, 8618-8624
16. Clapp, J. J., and Young, L. (1970) Biochem. J. 118, 765-771
17. Flanagan, J. U., Rossjohn, J., Parker, M. W., Board, P. G., and Chelvanayagam, G. (1999) Protein Sci. 8, 2205-2212
18. Mendes, P. (1993) Comput. Appl. Biosci. 9, 563-571
19. Mendes, P. (1997) Trends Biochem. Sci. 22, 361-363
20. Mendes, P., and Kell, D. B. (1998) Bioinformatics 14, 869-883
21. Henry, E. R., and Hofrichter, J. (1992) Methods Enzymol. 210, 129-192
22. Hendler, R. W., and Shrager, R. I. (1994) J. Biochem. Biophys. Methods 28, 1-33
23. Antonini, G., Bellelli, A., Brunori, M., and Falcioni, G. (1996) Biochem. J. 314, 533-540
24. Ivanetich, K. M., Goold, R. D., and Sikakana, C. N. T. (1990) Biochem. Pharmacol. 39, 1999-2004
25. Widersten, M., Björnestedt, R., and Mannervik, B. (1996) Biochemistry 35, 7731-7742
26. Chen, W.-J., Graminski, G. F., and Armstrong, R. N. (1988) Biochemistry 27, 647-654
27. Ricci, G., Caccuri, A. M., LoBello, M., Rosato, N., Mei, G., Nicotra, M., Chiessi, E., Mazzetti, A. P., and Federici, G. (1996) J. Biol. Chem. 271, 16187-16192
28. Stella, L., Nicotra, M., Ricci, G., Rosato, N., and Di Iorio, E. (1999) Proteins 37, 1-9
29. Stella, L., Di Iorio, E., Nicotra, M., and Ricci, G. (1999) Proteins 37, 10-19
30. Stella, L., Caccuri, A. M., Rosato, N., Nicotra, M., Lo Bello, M., De Matteis, F., Mazzetti, A. P., Federici, G., and Ricci, G. (1998) J. Biol. Chem. 273, 23267-23273
31. Nieslanik, B. S., Dabrowski, M. J., Lyon, R. P., and Atkins, W. M. (1999) Biochemistry 38, 6971-6980
32. Parsons, J. F., Xiao, G., Gilliland, G. L., and Armstrong, R. N. (1998) Biochemistry 37, 6286-6294