Human Glutathione Transferase T2-2 Discloses Some Evolutionary Strategies for Optimization of Substrate Binding to the Active Site of Glutathione Transferases

Journal of Biological Chemistry

Volumn 276, Issue 8, 2001, Pages 5427-5431

  Caccuri, Anna Maria ^a   Antonini, Giovanni ^b,c   Board, Philip G ^d   Flanagan, Jack ^d   Parker, Michael W ^e   Paolesse, Roberto ^a   Turella, Paola ^a,c   Federici, Giorgio ^f   Lo Bello, Mario ^a   Ricci, Giorgio ^a,f  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY OF L'AQUILA   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d Biology and Environment   (Australia)

^e ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^f BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL BONDS; CRYSTALLOGRAPHY; ENZYMES; MUTAGENESIS; PROTONS; SPECTROSCOPIC ANALYSIS; SUBSTRATES;

ISOENZYMES;

BIOCHEMISTRY;

ALANINE; ARGININE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE T2 2; ISOENZYME; UNCLASSIFIED DRUG; 1 MENAPHTHYL SULFATE; 1-MENAPHTHYL SULFATE; GLUTATHIONE; GSTT2 PROTEIN, HUMAN; NAPHTHALENE DERIVATIVE;

ARTICLE; CRYSTALLOGRAPHY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME KINETICS; EVOLUTION; POTENTIOMETRY; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; SPECTROSCOPY; CATALYSIS; CHEMICAL MODEL; GENETICS; HUMAN; KINETICS; METABOLISM; MOLECULAR EVOLUTION;

ARGININE; CATALYSIS; EVOLUTION, MOLECULAR; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HUMANS; ISOENZYMES; KINETICS; MODELS, CHEMICAL; NAPHTHALENES;

EID: 0035937120     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M002819200     Document Type: Article

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