Enhanced production of anticoagulant hirudin in recombinant Saccharomyces cerevisiae by chromosomal δ-integration

Journal of Biotechnology

Volumn 85, Issue 1, 2001, Pages 41-48

  Kim, Myoung Dong ^a   Rhee, Sang Ki ^b   Seo, Jin Ho ^a  

^a Seoul National University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

integration; Copy number; Hirudin; Mitotic stability; Saccharomyces cerevisiae

Indexed keywords

BIOLOGICAL MATERIALS; BIOSYNTHESIS; CHROMOSOMES; PLANT CELL CULTURE; YEAST;

ANTICOAGULANT; HIRUDIN;

GENETIC ENGINEERING;

HIRUDIN;

ANTICOAGULATION; ARTICLE; CHROMOSOME; CONTROLLED STUDY; DRUG ISOLATION; FUNGAL GENETICS; GENE EXPRESSION; GENE SEQUENCE; MITOSIS; NONHUMAN; PRIORITY JOURNAL; RETROPOSON; SACCHAROMYCES CEREVISIAE; SEQUENCE ANALYSIS; STRAIN DIFFERENCE;

ANTITHROMBINS; CHROMOSOMES, FUNGAL; ESCHERICHIA COLI; GENE DOSAGE; GENETIC VECTORS; HIRUDINS; MUTAGENESIS, INSERTIONAL; RECOMBINANT PROTEINS; RETROELEMENTS; SACCHAROMYCES CEREVISIAE; TRANSFORMATION, GENETIC;

EID: 0035936615     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-1656(00)00376-X     Document Type: Article

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