Gabapentin - Yet another anti-epileptic for the treatment of neuropathic pain?;Gabapentin - Endnu et antiepileptikum til behandling af neuropatiske smerter?

Ugeskrift for Laeger

Volumn 163, Issue 4, 2001, Pages 454-458

  Kamp Jensen, Michael ^a   Werner, Mads U ^a  

^a HVIDOVRE HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; ANTIDEPRESSANT AGENT; CALCIUM CHANNEL; CARBAMAZEPINE; GABAPENTIN; PHENYTOIN;

ANALGESIC ACTIVITY; CLINICAL TRIAL; DIABETIC NEUROPATHY; DRUG EFFICACY; DRUG INDUCED DISEASE; DRUG MECHANISM; DRUG TOLERANCE; HUMAN; NOCICEPTION; POSTHERPETIC NEURALGIA; REVIEW;

ACETIC ACIDS; AMINES; ANALGESICS; ANTICONVULSANTS; CLINICAL TRIALS; CONTROLLED CLINICAL TRIALS; CYCLOHEXANECARBOXYLIC ACIDS; DIABETIC NEUROPATHIES; GAMMA-AMINOBUTYRIC ACID; HERPESVIRIDAE INFECTIONS; HUMANS; MULTICENTER STUDIES; NEURALGIA;

EID: 0035931290     PISSN: 00415782     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (40)

1. Ramsay RE. Clinical efficacy and safety of gabapentin. Neurology 1994; 44(suppl 5): S23-S30.
2. Rowbotham M, Harden N, Stacey B, Bernstein P, Magnus-Miller L. Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial. JAMA 1998; 280: 1837-42.
3. Backonja M, Beydoun A, Edwards KR, Schwartz SL, Fonseca V, Hes M et al. Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial. JAMA 1998; 280: 1831-6.
4. Magnus L. Nonepileptic uses of gabapentin. Epilepsia 1999; 40 (suppl 6): S66-S72.
5. Sindrup SH, Jensen TS. Efficacy of pharmacological treatments of neuropathic pain: an update and effect related to mechanism of drug action. Pain 1999; 83: 389-400.
6. McQuay H, Caroll D, Jadad AR, Wiffen P, Moore A. Anticonvulsant drugs for management of pain: a systematic review. BMJ 1995; 311: 1047-52.
7. Hansen HC. Treatment of chronic pain with antiepileptic drugs: a new era. South Med J 1999; 92: 642-9.
8. Beydoun A, Uthman BM, Sackellares JC. Gabapentin: pharmacokinetics, efficacy, and safely. Clin Neuropharmacol 1995; 18: 469-81.
9. Bockbrader HN. Clinical pharmacokinetics of gabapentin. Drugs Today 1995; 31: 613-9.
10. Maurer HH, Rump AF. Intestinal absorption of gabapentin in rats. Arzneimittelforschung 1991; 41: 104-6.
11. Stewart BH, Kugler AR, Thompson PR, Bockbrader HN. A saturable transport mechanism in the intestinal absorption of gabapentin is the underlying cause of the lack of proportionality between increasing dose and drug levels in plasma. Pharm Res 1993; 10: 276-81.
12. Bryans JS, Wustrow DJ. 3-substituted GABA analogs with central nervous system activity: a review. Med Res Rev 1999; 19: 149-77.
13. Partridge BJ, Chaplan SR, Sakamoto E, Yaksh TL. Characterization of the effects of gabapentin and 3-isobutyl-gamma-aminobutyric acid on substance P-induced thermal hyperalgesia. Anesthesiology 1998; 88: 196-205.
14. Taylor CP. Mechanisms of action of gabapentin. Rev Neurol (Paris) 1997; 153 (suppl 1): S39-S45.
15. Abdi S, Lee DH, Chung JM. The anti-allodynic effects of amitriptyline, gabapentin, and lidocaine in a rat model of neuropathic pain. Anesth Analg 1998; 87: 1360-6.
16. Chapman V, Suzuki R, Chamarette HL, Rygh LJ, Dickenson AH. Effects of systemic carbamazepine and gabapentin on spinal neuronal responses in spinal nerve ligated rats. Pain 1998; 75: 261-72.
17. Hwang JH, Yaksh TL. Effect of subarachnoid gabapentin on tactile-evoked allodynia in a surgically induced neuropathic pain model in the rat. Reg Anesth 1997; 22: 249-56.
18. Chen SR, Eisenach JC, McCaslin PP, Pan HL. Synergistic effect between intrathecal non-NMDA antagonist and gabapentin on allodynia induced by spiral nerve ligation in rats. Anesthesiology 2000; 92: 500-6.
19. Field MJ, McCleary S, Hughes J, Singh L. Gabapentin and pregabalin, but not morphine and amitriptyline, block both static and dynamic components of mechanical adodynia induced by streptozocin in the rat. Pain 1999; 80: 391-8.
20. Cesena RM, Calcutt NA. Gabapentin prevents hyperalgesia during the formalin test in diabetic rats. Neurosci Lett 1999; 262: 101-4.
21. Jun JH, Yaksh TL. The effect of intrathecal gabapentin and 3-isobutyl gamma-aminobutyric acid on the hyperalgesia observed after thermal injury in the rat. Anesth Analg 1998; 86: 348-54.
22. Jones DL, Sorkin LS. Systemic gabapentin and S(+)-3-isobutyl-gamma-aminobutyric acid block secondary hyperalgesia. Brain Res 1998; 810: 93-9.
23. Field MJ, Holloman EF, McCleary S, Hughes J, Singh L. Evaluation of gabapentin and S-(+)-3-isobutylgaba in a rat model of postoperative pain. J Pharmacol Exp Ther 1997; 282: 1242-6.
24. Cheng JK, Pan HL, Eisenach JC. Antiallodynic effect of intrathecal gabapentin and its interaction with clonidine in a rat model of postoperative pain. Anesthesiology 2000; 92: 1126-31.
25. Kissin I, Lee SS, Bradley ELJ. Effect of prolonged nerve block on inflammatory hyperalgesia in rats: prevention of late hyperalgesia. Anesthesiology 1998; 88: 224-32.
26. Taylor CP, Gee NS, Su TZ, Kocsis JD, Welty DF, Brown JP et al. A summary of mechanistic hypotheses of gabapentin pharmacology. Epilepsy Res 1998; 29: 233-49.
27. Gidal BE, Radulovic LL, Kruger S, Rutecki P, Pitterle M, Bockbrader HN. Inter- and intra-subject variability in gabapentin absorption and absolute bioavailability. Epilepsy Res 2000; 40: 123-7.
28. Watson CP, Evans RJ, Reed K, Merskey H, Goldsmith L, Warsh J. Amitriptyline versus placebo in postherpetic neuralgia. Neurology 1982; 32: 671-3.
29. Max MB, Culnane M, Schafer SC, Gracely RH, Walther DJ, Smoller B et al. Amitriptyline relieves diabetic neuropathy pain in patients with normal or depressed mood. Neurology 1987; 37: 589-96.
30. Chadda VS, Mathur MS. Double blind study of the effects of diphenylhydantoin sodium on diabetic neuropathy. J Assoc Physicians India 1978; 26: 403-6.
31. Rull JA, Quibrera R, Gonzalez-Millan H, Lozano CO. Symptomatic treatment of peripheral diabetic neuropathy with carbamazepine (Tegretol): double blind crossover trial. Diabetologia 1969; 5: 215-8.
32. Morello CM, Leckband SG, Stoner CP, Moorhouse DF, Sahagian GA. Randomized double-blind study comparing the efficacy of gabapentin with amitriptyline on diabetic peripheral neuropathy pain. Arch Intern Med 1999; 159: 1931-7.
33. Gorson KC, Schott C, Herman R, Ropper AH, Rand WM. Gabapentin in the treatment of painful diabetic neuropathy: a placebo controlled, double blind, crossover trial [letter]. J Neurol Neurosurg Psychiatry 1999; 66: 251-2.
34. McQuay HJ, Moore RA, Wall PD, Melzack R, eds.Textbook of pain. Fourth ed. London: Churchill Livingstone, 1999: 1125-38. (Methods of therapeutic trials).
35. Gould HJ. Gabapentin induced polyneuropathy. Pain 1998; 74: 341-3.
36. Gonzalez-Sicilia L, Cano A, Serrano M, Hernandez J. Stevens-Johnson syndrome associated with gabapentin [letter]. Am J Med 1998; 105: 455.
37. Picard C, Jonville-Bera AP, Billard C, Autret E. Alopecia associated with gabapentin: first case [letter]. Ann Pharmacother 1997; 31: 1260.
38. Gabapentin in partial epilepsy. UK Gabapentin Study Group. Lancet 1990; 335: 1114-7.
39. Fischer JH, Barr AN, Rogers SL, Fischer PA, Trudeau VL. Lack of serious toxicity following gabapentin overdose. Neurology 1994; 44: 982-3.
40. Verma A, St Clair EW, Radtke RA. A case of sustained massive gabapentin overdose without serious side effects. Ther Drug Monit 1999; 21: 615-7.