Inter- and intra-subject variability in gabapentin absorption and absolute bioavailability

Epilepsy Research

Volumn 40, Issue 2-3, 2000, Pages 123-127

  Gidal, Barry E ^a   Radulovic, L L ^b   Kruger, Sarah ^a   Rutecki, Paul ^a   Pitterle, Michael ^c   Bockbrader, Howard N ^b  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b Dynam Metab Parke Davis P ^*  (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Absorption; Gabapentin; Non metabolized

Indexed keywords

GABAPENTIN;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG MONITORING; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VOLUNTEER;

ACETIC ACIDS; ADULT; AMINES; ANALYSIS OF VARIANCE; ANTICONVULSANTS; CROSS-OVER STUDIES; CYCLOHEXANECARBOXYLIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG MONITORING; FEMALE; GAMMA-AMINOBUTYRIC ACID; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES;

EID: 0034129145     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-1211(00)00117-0     Document Type: Article

References (8)

1. Beydoun A. et al. Conversion to high dose gabapentin monotherapy in patients with medically refractory partial epilepsy. Epilepsia. 39:1998;188.
2. Boyd R.A., Turck D., Abel R.B., Sedman A.J., Bockbrader H.N. Effects of age and gender on single-dose pharmacokinetics of gabapentin. Epilepsia. 40:1999;474-479.
3. Gidal B.E., DeCerce J., Bockbrader H.N. et al. Gabapentin bioavailability: effect of dose and frequency of administration in adult patients with epilepsy. Epilepsy Res. 31:1998;91-99.
4. Hellrigel E.T., Bjornsson T.D., Huack W.W. Interpatient variability in bioavailability is related to the extent of absorption: implications for bioavailability and bioequivalence studies. Clin. Pharmacol. Ther. 60:1996;601-607.
5. Lensmeyer G., Kempf T., Gidal B., Weibe D. Optimized method for determination of gabapentin in serum by HPLC. Ther. Drug Monit. 17:1995;251-258.
6. McLean M.J. Clinical pharmacokinetics of gabapentin. Neurology. 44:1994;S17-S22.
7. Stewart B.H., Kugler A.R., Thompson P.R., Bockbrader H.N. A saturable transport mechanism in the intestinal absorption of gabapentin is the underlying cause of the lack of proportionality between increasing dose and drug levels in plasma. Pharm. Res. 10:1993;276-282.
8. Stevenson C.M., Kim J., Fleisher D. Colonic absorption of antiepileptic agents. Epilepsia. 38:1997;63-67.