Design and synthesis of non-peptidic inhibitors for the Syk C-terminal SH2 domain based on structure-based in-silico screening

Journal of Medicinal Chemistry

Volumn 44, Issue 26, 2001, Pages 4737-4740

  Niimi, T ^a   Orita, M ^a   Okazawa Igarashi, M ^a   Sakashita, H ^a   Kikuchi, K ^a   Ball, E ^a   Ichikawa, A ^a   Yamagiwa, Y ^a   Sakamoto, S ^a   Tanaka, A ^a   Tsukamoto, S ^a   Fujita, S ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MALONIC ACID DERIVATIVE; PHOSPHOTYROSINE; PROTEIN KINASE SYK; PROTEIN TYROSINE KINASE INHIBITOR; SILICON; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; LIGAND BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

BINDING, COMPETITIVE; CYCLOHEXANES; ENZYME PRECURSORS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MALONATES; MODELS, MOLECULAR; MOLECULAR MIMICRY; PHOSPHOTYROSINE; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE KINASES; SRC HOMOLOGY DOMAINS;

EID: 0035924234     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010313k     Document Type: Article

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