Distinct functional properties of the TAP subunits coordinate the nucleotide-dependent transport cycle

Current Biology

Volumn 11, Issue 4, 2001, Pages 242-251

  Alberts, Philipp ^a   Daumke, Oliver ^a   Deverson, Edward V ^b   Howard, Jonathan C ^a   Knittler, Michael R ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0035916358     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00073-2     Document Type: Article

References (43)

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19. Structurally and catalytically important residues in the phosphate binding loop of adenylate kinase of Escherichia coli
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30. Human transporters associated with antigen processing possess a promiscuous peptide-binding site
31. Identification of a contact region for peptide on the TAP1 chain of the transporter associated with antigen processing
32. The major substrates for TAP in vivo are derived from newly synthesized proteins
33. Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state
34. MHC class I/beta 2-microglobulin complexes associate with TAP transporters before peptide binding
35. Major histocompatibility complex class I molecules interact with both subunits of the transporter associated with antigen processing, TAP1 and TAP2
36. Homozygous deletions that simultaneously eliminate expressions of class I and class II antigens of EBV-transformed B-lymphoblastoid cells. I. Reduced proliferance responses of autologous and allogeneic T cells that have decreased expression of class II antigens
37. Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation
38. MHC class II region encoding proteins related to the multidrug resistance family of transmembrane transporters
39. Restoration of antigen presentation to the mutant cell line RMA-S by an MHC-linked transporter
40. A human beta-actin expression vector system directs high-level accumulation of antisence transcripts
41. MHC class I molecules compete in the endoplasmic reticulum for access to transporter associated with antigen processing
42. Walker A lysine mutations of TAP1 and TAP2 interfere with peptide translocation but not peptide binding