Malonyl α-mercaptoketones and α-mercaptoalcohols, a new class of matrix metalloproteinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 10, 1998, Pages 1157-1162

  Campbell, David A ^a   Xiao, Xiao Yi ^a   Harris, David ^a   Ida, Satoru ^a   Mortezaei, Reza ^a   Ngu, Khehyong ^a   Shi, Lihong ^a   Tien, David ^a   Wang, Yongwen ^a   Navre, Marc ^a   Patel, Dinesh V ^a   Sharr, Michele A ^b   DiJoseph, John F ^b   Killar, Loran M ^b   Leone, Christina L ^b   Levin, Jeremy I ^b   Skotnicki, Jerauld S ^b  

^a AFFYMAX RESEARCH INSTITUTE   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DERIVATIVE; COLLAGENASE; GELATINASE B; KETONE DERIVATIVE; MALONIC ACID DERIVATIVE; MARIMASTAT; MATRIX METALLOPROTEINASE INHIBITOR; STROMELYSIN; THIOL DERIVATIVE; ZINC;

ARTICLE; DRUG POTENCY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; LIGAND BINDING; STRUCTURE ACTIVITY RELATION;

ALCOHOLS; BINDING SITES; COLLAGENASES; DRUG DESIGN; HYDROXAMIC ACIDS; KETONES; KINETICS; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASE 9; METALLOENDOPEPTIDASES; MOLECULAR STRUCTURE; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS; ZINC;

EID: 17544385192     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00185-1     Document Type: Article

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