Factor VII central: A novel mutation in the catalytic domain that reduces tissue factor binding, impairs activation by factor Xa, and abolishes amidolytic and coagulant activity

Journal of Biological Chemistry

Volumn 271, Issue 48, 1996, Pages 30685-30691

  Bharadwaj, Dwaipayan ^a   Iino, Masaki ^a   Kontoyianni, Maria ^b   Smith, Kenneth J ^a   Foster, Donald C ^b   Kisiel, Walter ^a  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^b ZYMOGENETICS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 7; BLOOD CLOTTING FACTOR 7A; BLOOD CLOTTING FACTOR 9; COMPLEMENTARY DNA; ENZYME PRECURSOR; PROCOAGULANT; THROMBOPLASTIN;

ADULT; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BLOOD CLOTTING FACTOR 7 DEFICIENCY; CASE REPORT; COMPUTER MODEL; DENSITOMETRY; DNA SEQUENCE; ENZYME ACTIVATION; ENZYME ACTIVITY; EXON; GENE MUTATION; HOMOZYGOSITY; HUMAN; HYDROGEN BOND; MALE; MOLECULAR DYNAMICS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL;

ADULT; ASPARTIC ACID; BLOOD COAGULATION DISORDERS; FACTOR VII; FACTOR XA; HUMANS; HYDROGEN BONDING; MALE; MODELS, MOLECULAR; POINT MUTATION; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBOPLASTIN; TYROSINE;

EID: 0029849217     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.48.30685     Document Type: Article

References (34)

1. Shapiro, R., and Vallee, B. L. (1989) Biochemistry 28, 7401-7408
2. Davie, E. W., Fujikawa, K., and Kisiel, W. (1991) Biochemistry 30, 10363-10370
3. De Grouchy, J., Dautzenberg, M. D., Turleau, C., Beguin, S., and Chavin-Colin, F. (1984) Human Genet. 66, 230-233
4. O'Hara, P. J., Grant, F. J., Haldeman, B. A., Gray, C. L., Insley, M. Y., Hagen, F. S., and Murray, M. J. (1987) Proc. Natl. Acad. Sci. U. S. A. 84, 5158-5162
5. Ragni, M. V., Lewis, J. H., Spero, J. A., and Hasiba, U. C. (1981) Am. J. Hematol. 10, 79-88
6. Mariani, G., Mazzucconi, M. G., Hermans, J., Ciavarella, N., Failla, A., Hassan, H. J., Mannucci, P. M., Nenci, C. G., Orlando, M., Romoli, D., and Mandelli, F. (1981) Br. J. Haematol. 48, 7-14
7. Triplett, D. A., Brandt, J. T., Batard, M. A., Dixon, J. S., and Fair, D. S. (1985) Blood 66, 1284-1287
8. Tuddenham, E. G. D., Pemberton, S., and Cooper, D. N. (1995) Thromb. Haemostasis 74, 313-321
9. Kondo, S., and Kisiel, W. (1987) Blood 70, 1947-1954
10. Pedersen, A. H., Lund-Hansen, T., Bisgaard-Frantzen, H., Olsen, F., and Petersen, L. C. (1989) Biochemistry 28, 9331-9336
11. Petersen, L. C., Sprecher, C. A., Foster, D. C., Blumberg, H., Hamamoto, T., and Kisiel, W. (1996) Biochemistry 35, 266-272
12. Nawroth, P. P., Kisiel, W., and Stern, D. M. (1986) Thromb. Res. 44, 625-637
13. Bell, W. N., and Alton, H. C. (1954) Nature 174, 880-881
14. Wildgoose, P., and Kisiel, W. (1989) Blood 73, 1888-1895
15. Kohler, G., and Milstein, C. (1975) Nature 256, 495-497
16. Nakagaki, T., Foster, D. C., Berkner, K. L., and Kisiel, W. (1991) Biochemistry 30, 10819-10824
17. Wu, J., Griffith, B. B., Bassinger, S., Moehlenkamp, C., Brodie, S. G., Wu, Y., Gribble, G. G., Troup, G. M., and Williams, T. M. (1996) Mol. Diag. 1, 89-98
18. Chaing, S., Clarke, B., Sridhara, S., Chu, K., Friedman, P., Van Dusen, W., Roberts, H. R., Blajchman, M., Monroe, D. M., and High, K. A. (1994) Blood 83, 3524-3535
19. Laemmli, U. K. (1970) Nature 227, 680-685
20. Kazama, Y., Pastuszyn, A., Wildgoose, P., Hamamoto, T., and Kisiel, W. (1993) J. Biol. Chem. 268, 16231-16240
21. Engvall, E. (1980) Methods Enzymol. 70, 419-439
22. Wildgoose, F., Berkner, K. L., and Kisiel, W. (1990) Biochemistry 29, 3413-3420
23. Kuwada, M., and Katayama, K. (1981) Anal. Biochem. 117, 259-265
24. Padmanabhan, K., Padmanabhan, K. P., Tulinsky, A., Park, C. H., Bode, W., Huber, R., Blankenship, D. T., Cardin, A. D., and Kisiel, W. (1993) J. Mol. Biol. 232, 947-966
25. MaloneyHuss, K., and Lybrand, T. P. (1992) J. Mol. Biol. 225, 859-871
26. Kontoyianni, M., and Lybrand, T. P. (1993) Perspect. Drug Disc. Des. 1, 291-300
27. Pedersen, A. H., Nordfang, O., Norris, F., Wiberg, F. C., Christensen, P. M., Moeller, K. B., Meidal-Pedersen, J., Beck, T. C., Norris, K., Hedner, U., and Kisiel, W. (1990) J. Biol. Chem. 265, 16786-16793
28. Matsushita, T., Kojima, T., Emi, N., Takahashi, I., and Saito, H. (1994) J. Biol. Chem. 269, 7355-7363
29. Neuenschwander, P. F., and Morrissey, J. H. (1994) J. Biol. Chem. 269, 8007-8013
30. Schullek, J. R., Ruf, W., and Edgington, T. S. (1994) J. Biol. Chem. 269, 19399-19403
31. Stone, M. J., Ruf, W., Miles, D. J., Edgington, T. S., and Wright, P. E. (1995) Biochem. J. 310, 605-614
32. Nakagaki, T., Lin, P., and Kisiel, W. (1992) Thromb. Res. 65, 105-116
33. Banner, D. W., D'Arcy A., Chene, C., Winkler, F. K., Guha, A., Konigsberg, W. H., Nemerson, Y., and Kirchhofer, D. (1996) Nature 380, 41-46
34. Hagen, F. S., Gray, C. L., O'Hara, P., Grant, F. J., Saari, G. C, Woodbury, R. G., Hart, C. E., Insley, M., Kisiel, W., Kurachi, K., and Davie, E. W. (1986) Proc. Natl. Acad. Sci. U. S. A. 83, 2412-2416