Dose-dependent induction of 8-hydroxyguanine and preneoplastic foci in rat liver by a food-derived carcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, at low dose levels

Japanese Journal of Cancer Research

Volumn 87, Issue 2, 1996, Pages 127-133

  Kato, Toshio ^a   Hasegawa, Ryohei ^a   Nakae, Dai ^c   Hirose, Masao ^a   Yaono, Makoto ^a   Cui, Lin ^a   Kobayashi, Yozo ^c   Konishi, Yoichi ^c   Ito, Nobuyuki ^b   Shirai, Tomoyuki ^a  

^a NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

^b NAGOYA CITY UNIVERSITY   (Japan)

^c NARA MEDICAL UNIVERSITY   (Japan)

Author keywords

8 hydroxyguanine; GST P positive foci; Liver carcinogenesis; MeIQx; Rat

Indexed keywords

2 AMINO 3,8 DIMETHYLIMIDAZO[4,5 F]QUINOXALINE; 8 HYDROXYGUANINE; CARCINOGEN; GLUTATHIONE TRANSFERASE; PLACENTA ENZYME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DNA ADDUCT; DOSE RESPONSE; LIVER CARCINOGENESIS; MALE; NONHUMAN; OXIDATION; PARTIAL HEPATECTOMY; PRECANCER; PRIORITY JOURNAL; RAT;

EID: 13344275858     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.1996.tb03149.x     Document Type: Article

References (45)

1. Ohgaki, H., Takayama, S. and Sugimura, T. Carcinogenicities of heterocyclic amines in cooked food. Mutat. Res., 259, 399-410 (1991).
2. Wakabayashi, K., Nagao, M., Esumi, H. and Sugimura, T. Food-derived mutagens and carcinogens. Cancer Res., 52, 2092s-2098s (1992).
3. Weisburger, J. H. Heterocyclic amines in cooked foods: possible human carcinogens. Cancer Res., 53, 2422-2424 (1993).
4. Kasai, H., Yamaizumi, Z., Shiomi, T., Yokoyama, S., Miyazawa, T., Wakabayashi, K., Nagao, M., Sugimura, T. and Nishimura, S. Structure of a potent mutagen isolated from fried beef. Chem. Lett., 12, 485-488 (1981).
5. Nakayasu, M., Nakasato, F., Sakamoto, H., Terada, M. and Sugimura, T. Mutagenic activity of heterocyclic amines in Chinese hamster lung cells with diphtheria toxin resistance as a marker. Mutat. Res., 118, 91-102 (1983).
6. Ohgaki, H., Hasegawa, H., Suenaga, M., Sato, S., Takayama, S. and Sugimura, T. Carcinogenicity in mice of a mutagenic compound, 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline (MeIQx) from cooked food. Carcinogenesis, 8, 665-668 (1987).
7. Kato, T., Ohgaki, H., Hasegawa, H., Sato, S., Takayama, S. and Sugimura, T. Carcinogenicity in rats of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4,5-f]-quinoxaline. Carcinogenesis, 9, 71-74 (1988).
8. Kushida, H., Wakabayashi, K., Sato, H., Katami, M., Kurosawa, R. and Nagao, M. Dose-response study of MeIQx carcinogenicity in F344 male rats. Cancer Lett., 83, 31-35 (1994).
9. Felton, J. S. and Knize, M. G. Occurrence, identification, and potential mutagenicity of heterocyclic amines in cooked food. Mutat. Res., 259, 205-217 (1991).
10. Ushiyama, H., Wakabayashi, K., Hirose, M., Itoh, H., Sugimura, T. and Nagao, M. Presence of carcinogenic heterocyclic amines in urine of healthy volunteers eating normal diet, but not in patients receiving parenteral alimentation. Carcinogenesis, 12, 1417-1422 (1991).
11. Layton, D. W., Bogen, K. T., Knize, M. K., Hatch, F. T., Johnson, V. M. and Felton, J. S. Cancer risk of heterocyclic amines in cooked foods: an analysis and implications for research. Carcinogenesis, 16, 39-52 (1995).
12. Yamashita, K., Adachi, M., Kato, S., Nakagama, H., Ochiai, M., Wakabayashi, K., Sato, S., Nagao, M. and Sugimura, T. DNA adducts formed by 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in rat liver: dose-response on chronic administration. Jpn. J. Cancer Res., 81, 470-476 (1990).
13. Alldrick, A. J., Ho, T. A., Rowland, I. R., Phillips, D. H. and Ni She, M. Influence of dietary fat on DNA binding by 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in the mouse liver. Food Chem. Toxicol., 31, 483-489 (1993).
14. Frantz, C. E., Bangerter, C., Fultz, E., Mayer, K. M., Vogel, J. S. and Turteltaub, K. W. Dose-response studies of MeIQx in rat liver and liver DNA at low doses. Carcinogenesis, 16, 367-373 (1995).
15. Hirose, M., Wakabayashi, K., Ochiai, M., Kushida, H., Sato, H., Sugimura, T. and Nagao, M. Formation and removal of DNA adducts in the liver of rats chronically fed the food-borne carcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline. Jpn. J. Cancer Res., 86, 516-522 (1995).
16. Shirai, T., Tada, M., Kojima, M., Hasegawa, R., Masui, T. and Ito, N. DNA adducts in target and nontarget tissues of 3,2′-dimethyl-4-aminobiphenyl in rats. Environ. Health Perspect., 102, 167-172 (1994).
17. Takayama, K., Yamashita, K., Wakabayashi, K., Sugimura, T. and Nagao, M. DNA modification by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rats. Jpn. J. Cancer Res., 80, 1145-1148 (1989).
18. Nihro, Y., Furukawa, H., Sogawa, S., Wang, T. H., Miyataka, H., Matsumoto, H., Miki, T. and Satoh, T. Synthesis and anti-peroxidation activity of hydroquinone monoalkyl ethers. Chem. Pharm. Bull., 42, 576-579 (1994).
19. Hirose, M., Ito, N. and Satoh, T. A strong new antioxidant with potent chemopreventive activity against heterocyclic amine-induced mutagenesis and carcinogenesis: HTHQ. Drug News Preserv., 7, 167-170 (1994).
20. Hirose, M., Hasegawa, R., Kimura, J., Akagi, K., Yoshida, Y., Tanaka, H., Miki, T., Satoh, T., Wakabayashi, K., Ito, N. and Shirai, T. Inhibitory effects of 1-O-hexyl-2,3,5-trimethylhydroquinone (HTHQ), green tea catechins and other antioxidants on 2-amino-6-methyldipyrido[1, 2-a:3′, 2′-d]imidazole (Glu-P-1)-induced rat hepatocarcinogenesis and dose dependent inhibition by HTHQ of lesion induction by Glu-P-1 or 2-amino-3,8-dimethylimidazo[4, 5-b]quinoxaline (MeIQx). Carcinogenesis (1995) in press.
21. Kuchino, Y., Mori, F., Kasai, H., Inoue, H., Iwai, S., Miura, K., Ohtsuka, E. and Nishimura, S. Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues. Nature, 327, 77-79 (1987).
22. Shibutani, S., Takeshita, M. and Grollman, A. P. Insertion of specific bases during DNA synthesis past oxidation-damaged base 8-oxodG. Nature, 349, 431-434 (1991).
23. Cheng, K. C., Cahill, D. S., Kasai, H., Nishimura, S. and Loeb, L. A. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G → T and A → C substitutions. J. Biol. Chem., 267, 166-172 (1992).
24. Moriya, M. Single-stranded shuttle phagemid for mutagenesis studies in mammalian cells. 8-Oxoguanine in DNA induces targeted G·C → T·A transversions in simian kidney cells. Proc. Natl. Acad. Sci. USA, 90, 1122-1126 (1993).
25. Floyd, R. A. The role of 8-hydroxyguanine in carcinogenesis. Carcinogenesis, 11, 1447-1450 (1990).
26. Hayakawa, M., Torii, K., Sugiyama, S., Tanaka, M. and Ozawa, T. Age associated accumulation of 8-hydroxydeoxyguanosine in mitochondrial DNA of human diaphragm. Biochem. Biophys. Res. Commun., 179, 1023-1029 (1991).
27. Lindahl, T. Instability and decay of the primary structure of DNA. Nature, 362, 709-715 (1993).
28. Clayson, D. B., Mehta, R. and Iverson, F. and International Commission for Protection against Environmental Mutagens and Carcinogens. Oxidative DNA damage - the effects of certain genotoxic and operationally nongenotoxic carcinogens. Mutat. Res., 317, 25-42 (1994).
29. Ito, N., Tsuda, H., Tatematsu, M., Inoue, T., Tagawa, Y., Aoki, T., Uwagawa, S., Kagawa, M., Ogiso, T., Masui, T., Imaida, K., Fukushima, S. and Asamoto, M. Enhancing effect of various hepatocarcinogens on induction of preneoplastic glutathione S-transferase placental form positive foci in rats - an approach for a new medium-term bioassay system. Carcinogenesis, 9, 387-394 (1988).
30. Hasegawa, R. and Ito, N. Liver medium-term bioassay in rats for screening of carcinogens and modifying factors in hepatocarcinogenesis. Food Chem. Toxicol., 30, 979-992 (1992).
31. Tatematsu, M., Mera, Y., Ito, N., Satoh, K. and Sato, K. Relative merits of immunohistochemical demonstrations of placental A, B, and C forms of glutathione S transferase and histochemical demonstration of γ-glutamyltransferase as markers of altered foci during liver carcinogenesis in rats. Carcinogenesis, 6, 1621-1626 (1985).
32. Nakae, D., Mizumoto, Y., Kobayashi, E., Noguchi, O. and Konishi, Y. Improved genomic/nuclear DNA extraction for 8-hydroxydeoxyguanosine analysis of small amounts of rat liver tissue. Cancer Lett. (1995) in press.
33. Takagi, A., Sai, K., Umemura, T., Hasegawa, R. and Kurokawa, Y. Significant increase of 8-hydroxydeoxyguanosine in liver DNA of rats following short-term exposure to the peroxisome proliferators di(2-ethylhexyl)phthalate and di(2-ethylhexyl)adipate. Jpn. J. Cancer Res., 81, 213-215 (1990).
34. Kasai, H., Nishimura, S., Kurokawa, Y. and Hayashi, Y. Oral administration of the renal carcinogen, potassium bromate, specifically produces 8-hydroxydeoxyguanosine in rat target organ DNA. Carcinogenesis, 8, 1959-1961 (1987).
35. Nakae, D., Andoh, N., Mizumoto, Y., Endoh, T., Shimoji, N., Horiguchi, K., Shiraiwa, K., Tamura, K., Denda, A. and Konishi, Y. Selective 8-hydroxyguanine formation in pancreatic DNA due to a single intravenous administration of 4-hydroxyaminoquinoline 1-oxide in rats. Cancer Lett., 83, 97-103 (1994).
36. Gross, G. A., Turesky, R. J., Fay, L. B., Stillwell, W. G., Skipper, P. L. and Tannenbaum, S. R. Heterocyclic aromatic amine formation in grilled bacon, beef and fish and grill scrapings. Carcinogenesis, 14, 2313-2318 (1993).
37. Skog, K., Steineck, G., Augustsson, K. and Jägerstad, M. Effect of cooking temperature on the formation of heterocyclic amines in fried meat products and pan residues. Carcinogenesis, 16, 861-867 (1995).
38. 32P-postlabeling method, in the liver of rats fed MeIQx. Carcinogenesis, 14, 2165-2170 (1993).
39. Rich, K. J., Murray, B. P., Lewis, I., Rendell, N. B., Davies, D. S., Gooderham, N. J. and Boobis, A. R. N-Hydroxy-MeIQx is the major microsomal oxidation product of the dietary carcinogen MeIQx with human liver. Carcinogenesis, 13, 2221-2226 (1992).
40. Hirose, M., Akagi, K., Hasegawa, R., Yaono, M., Satoh, T., Hara, Y., Wakabayashi, K. and Ito, N. Chemoprevention of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary gland carcinogenesis by antioxidants in F344 female rats. Carcinogenesis, 16, 217-221 (1995).
41. Hirose, M., Iwata, S., Ito, E., Nihro, Y., Takahashi, S., Mizoguchi, Y., Miki, T., Satoh, T., Ito, N. and Shirai, T. Strong anti-mutagenic activity of the novel lipophilic antioxidant 1-O-hexyl-2,3,5-trimethylhydroquinone against heterocyclic amine-induced mutagenesis in the Ames assay and its effect on metabolic activation of 2-amino-6-methyldipyrido[1,2-a:3′,2′-d]imidazole (Glu-P-1). Carcinogenesis, 16, 2227-2232 (1995).
42. Sone, H., Wakabayashi, K., Kushida, H., Sugimura, T. and Nagao, M. Induction of preneoplastic lesions by a low dose of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in the livers of rats treated with carbon tetrachloride. Carcinogenesis, 13, 793-797 (1992).
43. Sone, H., Wakabayashi, K., Kushida, H., Ochiai, M., Sugimura, T. and Nagao, M. Effects of chronic administration of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline on glutathione S-transferase placental form-positive foci development in the livers of rats fed a choline-deficient diet. Jpn. J. Cancer Res., 84, 859-864 (1993).
44. Sai, K., Takagi, A., Umemura, T., Hasegawa, R. and Kurokawa, Y. Changes of 8-hydroxydeoxyguanosine levels in rat organ DNA during the aging process. J. Environ. Pathol. Toxicol. Oncol., 11, 139-143 (1992).
45. Wang, Y.-J., Ho, Y.-S., Lo, M.-J. and Lin, J.-K. Oxidative modification of DNA bases in rat liver and lung during chemical carcinogenesis and aging. Chem.-Biol. Interact., 94, 135-145 (1995).