The effects of 1-nitropyrene, 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine and 7,12-dimethylbenz[a]anthracene on 8-hydroxy-2'-deoxyguanosine levels in the rat mammary gland and modulation by dietary 1,4- phenylenebis(methylene)selenocyanate

Cancer Letters

Volumn 151, Issue 1, 2000, Pages 7-13

  El Bayoumy, Karam ^a   Chae, Young Heum ^a   Rosa, José G ^a   Williams, Leeann K ^a   Desai, Dhimant ^a   Amin, Shantu ^a   Fiala, Emerich ^a  

^a AMERICAN HEALTH FOUNDATION   (United States)

Author keywords

Heterocyclic amines; Nitroaromatics; Oxidative damage; Polycyclic aromatic hydrocarbons; Selenium

Indexed keywords

1 NITROPYRENE; 1,4 PHENYLENEBIS(METHYLENE)SELENOCYANATE; 2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; 7,12 DIMETHYLBENZ[A]ANTHRACENE; 8 HYDROXYDEOXYGUANOSINE; AROMATIC NITRO COMPOUND; HETEROCYCLIC AMINE; POLYCYCLIC AROMATIC HYDROCARBON; SELENIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CONTROLLED STUDY; COVALENT BOND; DNA DAMAGE; DRUG EFFECT; ELECTRON TRANSPORT; ENVIRONMENTAL EXPOSURE; GENE ACTIVATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; ANTICARCINOGENIC AGENTS; CARCINOGENS; DEOXYGUANOSINE; DIET; DNA; FEMALE; IMIDAZOLES; MAMMARY GLANDS, ANIMAL; ORGANOSELENIUM COMPOUNDS; PYRENES; RATS; RATS, INBRED STRAINS;

ANIMALIA; RODENTIA; ZEA MAYS;

EID: 0034599906     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(99)00391-2     Document Type: Article

References (21)

1. El-Bayoumy K. Environmental carcinogens that may be involved in human breast cancer etiology. Chem. Res. Toxicol. 5:1992;585-590.
2. Welsch C. Host factors affecting the growth of carcinogen-induced rat mammary carcinomas: a review and tribute to Charles Brenton Huggins. Cancer Res. 45:1985;3415-3443.
3. Dipple A., Cheng S.C., Bigger C.A. Polycyclic aromatic hydrocarbon carcinogens. Prog. Clin. Biol. Res. 347:1990;109-127.
4. Coles C., Condie A., Chetty U., Steel C.M., Evans H.J., Prosser J. p53 mutations in breast cancer. Cancer Res. 52:1992;5291-5298.
5. El-Bayoumy K., Chae Y.-H., Upadhyaya P., Rivenson A., Kurtzke K., Reddy B., Hecht S.S. Comparative tumorigenicity of benzo[a]pyrene. 1-nitropyrene, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine administered by gavage to female CD rats. Carcinogenesis. 16:1995;431-434.
6. Cheng K.C., Cahill D.S., Kasai H., Nishimura S., Loeb L.A. 8-Hydroxyguanine an abundant form of oxidative DNA damage, causes G-T and A-C substitutions. J. Biol. Chem. 267:1992;166-172.
7. Floyd R.A. The role of 8-hydroxyguanine in carcinogenesis. Carcinogenesis. 11:1990;1447-1450.
8. Malins D.C., Holmes E.H., Polissar N.L., Gunselman S.J. The etiology of breast cancer. Cancer. 71:1993;3036-3043.
9. El-Bayoumy K., Chae Y.-H., Upadhyaya P., Meschter C., Cohen L.A., Reddy B.S. Inhibition of 7,12-dimethylbenz[a]anthracene-induced tumors and DNA adduct formation in the mammary glands of female Sprague-Dawley rats by the synthetic organoselenium compound, 1,4-phenylenebis(methylene)selenocyanate. Cancer Res. 52:1992;2402-2407.
10. Ip C., El-Bayoumy K., Upadhyaya P., Ganther H., Vadhanavikit S., Thompsen H. Comparative effect of inorganic and organic selenocyanate derivatives in mammary cancer chemoprevention. Carcinogenesis. 15:1994;187-192.
11. Fiala E.S., Conaway C.C., Mathis J.E. Oxidative DNA and RNA damage in the livers of Sprague-Dawley rats treated with the hepatocarcinogen 2-nitropropane. Cancer Res. 49:1989;5518-5522.
12. Floyd R.A., Watson J.J., Wong P.K., Altimiller D.H., Rickard R.C. Hydroxyl free radical adduct of deoxyguanosine: sensitive detection. Free Radic. Res. Commun. 1:1986;163-172.
13. Fleiss J.L. The Design and Analysis of Clinical Experiments. 1986;58-59 Wiley, New York.
14. Frenkel K., Wei L., Wei H. 7,12-Dimethylbenz(a)anthracene induces oxidative DNA modification in vivo. Free Radic. Biol. Med. 19:1995;373-380.
15. Lin D.-X., Meyer D.J., Ketterer B., Lang N.P., Kadlubar F.F. Effects of human and rat glutathione-transferases on the covalent DNA binding of the N-acetoxy derivatives of heterocyclic amine carcinogens in vitro: a possible mechanism of organ-specificity in their carcinogenesis. Cancer Res. 54:1994;4920-4926.
16. Lin D.-X., Lang N.P., Kadlubar F.F. Species differences in the biotransformation of the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by hepatic microsomes and cytosols from humans, rats, and mice. Drug Metab. Dispos. 23:1995;518-524.
17. Sato K., Akaike T., Kojima Y., Ando M., Nagao M., Maeda H. Evidence of direct generation of oxygen free radicals from heterocyclic amines by NADPH/cytochrome P-450 reductase in vitro. Jpn. J. Cancer Res. 83:1992;1204-1209.
18. Kato T., Hasegawa R., Nakae D., Hirose M., Yaono M., Cui L., Kobayashi Y., Konishi Y., Ito N. Dose-dependent induction of 8-hydroxyguanine and preneoplastic foci in rat liver by a food-derived carcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinonaline, at low dose levels. Jpn. J. Cancer Res. 87:1996;127-133.
19. Djuric Z., Potter D.W., Culp S.J., Luongo D.A., Beland F.A. Formation of DNA adducts and oxidative DNA damage in rats treated with 1,6-dinitropyrene. Cancer Lett. 71:1993;51-56.
20. International Agency for Research on Cancer, Diesel and gasoline engine exhausts and some nitroarenes. IARC Monographs on the Evaluation of Carcinogenic Risk to Humans, Vol. 39, IARC, Lyon, France, 1989, p. 458.
21. Fu P.P., Herreno-Saenz D. Nitro-polycyclic aromatic hydrocarbons: a class of genotoxic environmental pollutants. Environ. Carcinogen. Ecotox. Tevs. C17:(1):1999;1-43.