1-[ω-(4-arylpiperazin-1-yl)alkyl]-3-diphenylmethylene-2,5-pyrrolidinediones as 5-HT(1A) receptor ligands: Study of the steric requirements of the terminal amide fragment on 5-HT(1A) affinity/selectivity

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 6, 1998, Pages 581-586

  López Rodríguez, Maria L ^a   Morcillo, M José ^b   Rovat, Tandú K ^a   Fernández, Esther ^a   Sanz, Antonio M ^a   Orensanz, Luis ^c  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b UNIVERSIDAD NACIONAL DE EDUCACIÓN A DISTANCIA   (Spain)

^c HOSPITAL RAMÓN Y CAJAL   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; ALPHA 1 ADRENERGIC RECEPTOR; DOPAMINE 2 RECEPTOR; PRAZOSIN; RACLOPRIDE; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; REACTION ANALYSIS; RECEPTOR AFFINITY;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; CEREBRAL CORTEX; CORPUS STRIATUM; DOPAMINE ANTAGONISTS; LIGANDS; MODELS, CHEMICAL; PRAZOSIN; PYRROLIDINONES; RACLOPRIDE; RATS; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, DOPAMINE D2; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SALICYLAMIDES; SEROTONIN AGONISTS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0032539880     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00074-2     Document Type: Article

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