Design, synthesis, and SAR of heterocycle-containing antagonists of the human CCR5 receptor for the treatment of HIV-1 infection

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 24, 2001, Pages 3103-3106

  Kim, Dooseop ^a   Wang, Liping ^a   Caldwell, Charles G ^a   Chen, Ping ^a   Finke, Paul E ^a   Oates, Bryan ^a   MacCoss, Malcolm ^a   Mills, Sander G ^a   Malkowitz, Lorraine ^a   Gould, Sandra L ^a   DeMartino, Julie A ^a   Springer, Martin S ^a   Hazuda, Daria ^a   Miller, Michael ^a   Kessler, Joseph ^a   Danzeisen, Renee ^a   Carver, Gwen ^a   Carella, Anthony ^a   Holmes, Karen ^a   Lineberger, Janet ^a   Schleif, William A ^a   Emini, Emilio A ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; CHEMOKINE RECEPTOR CCR5; HYDANTOIN DERIVATIVE; INDOLE DERIVATIVE; RECEPTOR BLOCKING AGENT;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BINDING; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANTI-HIV AGENTS; HELA CELLS; HETEROCYCLIC COMPOUNDS; HIV INFECTIONS; HIV-1; HUMANS; RECEPTORS, CCR5; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0035904879     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00655-2     Document Type: Article

References (13)