KIF1d is a fast non-processive kinesin that demonstrates novel K-loop-dependent mechanochemistry

EMBO Journal

Volumn 20, Issue 18, 2001, Pages 5101-5113

  Rogers, Kevin R ^a   Weiss, Stefan ^b   Crevel, Isabelle ^a   Brophy, Peter J ^c   Geeves, Michael ^b   Cross, Robert ^a  

^a MARIE CURIE RESEARCH INSTITUTE   (United Kingdom)

^b UNIVERSITY OF KENT   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

KIF1 family; Kinesin; L12 loop; Processivity; Weak to strong transition

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATASE; AMINO ACID; ARGININE; KINESIN; KINESIN 1 D; LYSINE; UNCLASSIFIED DRUG;

ARTICLE; GENE DELETION; GENE INSERTION; GENE MUTATION; ISOMERISM; KINETICS; MICROTUBULE; PRIORITY JOURNAL; STEADY STATE;

ADENOSINE DIPHOSPHATE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; ANTHRANILIC ACIDS; BIOMECHANICS; KINESIN; KINETICS; MICROTUBULES; MODELS, BIOLOGICAL; MOLECULAR MOTOR PROTEINS; MOLECULAR SEQUENCE DATA; MOVEMENT; MUTAGENESIS, INSERTIONAL; NERVE TISSUE PROTEINS; PROTEIN STRUCTURE, TERTIARY; SEQUENCE DELETION; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0035903699     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.18.5101     Document Type: Article

References (49)

1. Proteolytic mapping of kinesin/ncd-microtubule interface: Nucleotide-dependent conformational changes in the loops L8 and L12
2. The unc104/KIF1 family of kinesins
3. A novel brain ATPase with properties expected for the fast axonal transport motor
4. Role of the kinesin neck linker and catalytic core in microtubule-based motility
5. Detection of sub-8-nm movements of kinesin by high-resolution optical-trap microscopy
6. Kinesin takes one 8nm step for each ATP that it hydrolyzes
7. Weak and strong states of kinesin and ncd
8. Coupled chemical and mechanical reaction steps in a processive Neurospora kinesin
9. Walking talking heads
10. Molecular motors: Kinesin's dynamically dockable neck
11. The conformational cycle of kinesin
12. The emerging kinesin family of microtubule motor proteins
13. A mutant of the motor protein kinesin that moves in both directions on microtubules
14. Determinants of kinesin motor polarity
15. Kinetics of acto-S1 interaction as a guide to a model for the crossbridge cycle
16. Pathway of processive ATP hydrolysis by kinesin
17. Evidence for alternating head catalysis by kinesin during microtubule-stimulated ATP hydrolysis
18. Highly microtubule-stimulated ATP hydrolysis by dimeric kinesin head domains
19. Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans
20. The mechanisms of fast and slow transport in neurons: Identification and characterization of the new kinesin superfamily motors
21. Kinesin and dynein superfamily proteins in organelle transport and cell division
22. Coupling of kinesin steps to ATP hydrolysis
23. Influence of the kinesin neck domain on dimerization and ATPase kinetics
24. 15 Å resolution model of the monomeric kinesin motor KIF1A
25. Origins of reversed directionality in the ncd molecular motor
26. Kinetics and motility of the Eg5 microtubule motor
27. Kinesin and ncd bind through a single head to microtubules and compete for a shared MT binding site
28. ADP release is the rate-limiting step of the MT activated ATPase of non-claret disjunctional and kinesin
29. Interacting head mechanism of microtubule-kinesin ATPase
30. KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria
31. A processive single-headed motor: Kinesin superfamily protein KIF1A
32. Mechanism of the single-headed processivity: Diffusional anchoring between the K-loop of kinesin and the C terminus of tubulin
33. The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors
34. Single-molecule behavior of monomeric and heteromeric kinesins
35. A structural change in the kinesin motor protein that drives motility
36. The secretory epithelial cells of the choroid plexus employ a novel kinesin-related protein
37. The secretory epithelial cells of the choroid plexus employ a novel kinesin-related protein
38. Equilibrium studies of kinesin-nucleotide intermediates
39. Conformational changes during kinesin motility
40. Kinesin hydrolyses one ATP per 8-nm step
41. Expression, purification, ATPase properties and microtubule-binding properties of the ncd motor domain
42. ATPase kinetic characterization and single molecule behavior of mutant human kinesin motors defective in microtubule-based motility
43. Controlling kinesin by reversible disulfide cross-linking. Identifying the motility-producing conformational change
44. The way things move: Looking under the hood of molecular motor proteins
45. Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility
46. A flash photolysis fluorescence/light scattering apparatus for use with sub microgram quantities of muscle protein
47. Microtubule interaction site of the kinesin motor
48. Defect in synaptic vesicle precursor transport and neuronal cell death in KIF1A motor proteindeficient mice