Phenotype of Normal Cutaneous Microvasculature: Immunoelectron microscopic observations with emphasis on the differences between blood vessels and lymphatics

Journal of Investigative Dermatology

Volumn 106, Issue 1, 1996, Pages 135-140

  Erhard, Helmut ^a,b,c   Rietveld, Frank J R ^a   Bröcker, Eva B ^b   De Waal, Robert M W ^a   Ruiter, Dirk J ^a  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

Adhesion molecule; Double labeling; Endothelial antigen; Ultra small gold

Indexed keywords

ACTIN; CD31 ANTIGEN; COLLAGEN TYPE 4; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; PROTEOHEPARAN SULFATE; VASCULAR CELL ADHESION MOLECULE 1; VON WILLEBRAND FACTOR;

ADULT; ARTICLE; HUMAN; HUMAN TISSUE; LYMPH VESSEL; MALE; MICROVASCULATURE; NORMAL HUMAN; PRIORITY JOURNAL; SKIN BLOOD VESSEL;

CAPILLARIES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC SYSTEM; MALE; MICROCIRCULATION; MICROSCOPY, IMMUNOELECTRON; PHENOTYPE; REFERENCE VALUES; SKIN;

EID: 0030058931     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/1523-1747.ep12329708     Document Type: Article

References (26)

1. Rhodin JA: Ultrastructure of mammalian venous capillaries, venules, and small collecting veins. J Ultrastruct Res 25:452-500, 1968
2. Braverman IM: Ultrastructure and organization of the cutaneous microvasculature in normal and pathologic states. J Invest Dermatol 93:2S-9S, 1989
3. Hoyer LW, De los Santos RP, Hoyer JR: Antihemophilic factor antigen. Localization in endothelial cells by immunofluorescent microscopy. J Clin Invest 52:2737-2742, 1973
4. Cui YC, Tai PC, Gatter KC, Mason DY, Spry CJ: A vascular endothelial cell antigen with restricted distribution in human foetal, adult and malignant tissues. Immunology 49:183-189, 1983
5. Schlingemann RO, Dingjan GM, Emeis JJ, Blok J, Warnaar SO, Ruiter DJ: Monoclonal antibody PAL-E specific for endothelium. Lab Invest 52:71-76, 1985
6. Schlingemann RO, Rietveld FJ, Kwaspen F, van de Kerkhof PC, de Waal RM, Ruiter DJ: Differential expression of markers for endothelial cells, pericytes, and basal lamina in the microvasculature of tumors and granulation tissue. Am J Pathol 138:1335-1342, 1991
7. Nickoloff BJ: PECAM-1 (CD31) is expressed on proliferating endothelial cells, stromal spindle-shaped cells, and dermal dendrocytes in Kaposi's sarcoma. Arch Dermatol 129:250-251, 1993 (lett.)
8. Leak LV, Burke JF: Fine structure of the lymphatic capillary and the adjoining connective tissue area. Am J Anal 118:785-809, 1966
9. Berens von Rautenfeld D, Laubach D, Wenzel Hora B, Klanke J, Hunneshagen C: New techniques of demonstrating lymph vessels in skin biopsy specimens and intact skin with the scanning electron microscope. Arch Dermatol Res 279:327-334, 1987
10. Ryan TJ: Structure and function of lymphatics. J Invest Dermatol 93:18S-24S, 1989
11. van Duinen SG, Mauw BJ, de Graaff Reitsma CB, Ruiter DJ: Methods in laboratory investigation. Immunoelectron microscopic methods for demonstration of antigens on normal human melanocytes and other epidermal cells. Lab Invest 50:733-741, 1984
12. Danscher G: Localization of gold in biological tissue. A photochemical method for light and electronmicroscopy. Histochemistry 71:81-88, 1981
13. Tronnier M, Fehrenbacher B, Schaumburg Lever G, Hashimoto K: Ultrastructural localization of alpha-L-fucose, factor VIII related antigen and vimentin in endothelial cells of human skin blood vessels using the low temperature embedding technique with Lowicryl K4M. J Dermatol Sci 1:149-155, 1990
14. Beckstead JH, Wood GS, Fletcher V: Evidence for the origin of Kaposi's sarcoma from lymphatic endothelium. Am J Pathol 119:294-300, 1985
15. Diaz Flores L, Gutierrez R, Varela H, Rancel N, Valladares F: Microvascular pericytes: a review of their morphological and functional characteristics. Histol Histopathol 6:269-286, 1991
16. Nerlich AG, Schleicher E: Identification of lymph and blood capillaries by immunohistochemical staining for various basement membrane components Histochemistry 96:449-453, 1991
17. Nehls V, Denzer K, Drenckhahn D: Pericyte involvement in capillary sprouting during angiogenesis in situ. Cell Tissue Res 270:469-474, 1992
18. Dustin ML, Rothlein R, Bhan AK, Dinarello CA, Springer TA: Induction by II 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J Immunol 137:245-254, 1986
19. Groves RW, Allen MH, Barker JN, Haskard DO, MacDonald DM: Endothelial leucocyte adhesion molecule-1 (ELAM-1) expression in cutaneous inflammation. Br J Dermatol 124:117-123, 1991
20. Griffiths CE, Voorhees JJ, Nickoloff BJ: Characterization of intercellular adhesion molecule-1 and HLA-DR expression in normal and inflamed skin: modulation by recombinant gamma inteferon and tumor necrosis factor. J Am Acad Dermatol 20:617-629, 1989
21. Nelson WJ: Regulation of cell surface polarity from bacteria to mammals. Science 258:948-955, 1992
22. Newman PJ, Hillery CA, Albrecht R, Parise LV, Berndt MC, Mazurov AV, Dunlop LC, Zhang J, Rittenhouse SE: Activation-dependent changes in human platelet PECAM-1: phosphorylation, cytoskeletal association, and surface membrane redistribution. J Cell Biol 119:239-246, 1992
23. Albelda SM, Oliver PD, Romer LH, Buck CA: EndoCAM: a novel endothelial cell-cell adhesion molecule. J Cell Biol 110:1227-1235, 1990
24. Leach L, Clark P, Lampugnani MG, Arroyo AG, Dejana E, Firth JA: Immunoelectron characterisation of the inter-endothelial junctions of human term placenta. J Cell Sci 104:1073-1080, 1993
25. Albelda SM, Muller WA, Buck CA, Newman PJ: Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule. J Cell Biol 114:1059-1068, 1991
26. Norris P, Poston RN, Thomas DS, Thornhill M, Hawk J, Haskard DO: The expression of endothelial leukocyte adhesion molecule-1 (ELAM-1), intercellular adhesion molecule-1 (ICAM-1), and vascular adhesion molecule-1 (VCAM-1) in experimental cutaneous inflammation: a comparison of ultraviolet B erythema and delayed hypersensitivity. J Invest Dermatol 96:763-770, 1991