Phenoxybenzamine Binding Reveals the Helical Orientation of the Third Transmembrane Domain of Adrenergic Receptors

Journal of Biological Chemistry

Volumn 276, Issue 33, 2001, Pages 31279-31284

  Frang, Heini ^a   Cockcroft, Victor ^b   Karskela, Tuomas ^a   Scheinin, Mika ^a   Marjamäki, Anne ^c  

^a UNIVERSITY OF TURKU   (Finland)

^b ORION CORPORATION   (Finland)

^c Biotie Therapies Corp   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOLOGICAL MEMBRANES;

LIGANDS; TRANSMEMBRANES;

BIOCHEMISTRY;

ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA2A ADRENERGIC RECEPTOR; ALPHA2B ADRENERGIC RECEPTOR; ALPHA2C ADRENERGIC RECEPTOR; CYSTEINE; PHENOXYBENZAMINE; UNCLASSIFIED DRUG; VALINE;

ALPHA HELIX; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; RECEPTOR BINDING; THIRD TRANSMEMBRANE DOMAIN; ANIMAL; BINDING SITE; CELL MEMBRANE; CHEMISTRY; CHO CELL; GENETIC TRANSFECTION; HAMSTER; METABOLISM; MOLECULAR GENETICS; PROTEIN SECONDARY STRUCTURE; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

ANIMALIA;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL MEMBRANE; CHO CELLS; CRICETINAE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHENOXYBENZAMINE; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, ADRENERGIC; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 0035903167     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M104167200     Document Type: Article

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