5-HT3 antagonists derived from aminopyridazine-type muscarinic M1 agonists

Journal of Medicinal Chemistry

Volumn 41, Issue 3, 1998, Pages 311-317

  Rival, Yveline ^d   Hoffmann, Rémy ^b   Didier, Bruno ^d   Rybaltchenko, Volodymyr ^c,d   Bourguignon, Jean Jacques ^d   Wermuth, Camille G ^a  

^a Laboratoire de Pharmacochimie   (France)

^b Parc Club Orsay Universite   (France)

^c UNIVERSITÉ DE STRASBOURG   (France)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

1 (4' METHYLPIPERAZIN 1 YL)PHTHALAZINE; 3 (2 DIETHYLAMINO 2 METHYLPROPYLAMINO) 6 PHENYL 5 PROPYLPYRIDAZINE; 3 (4' METHYLPIPERAZIN 1 YL) 5 PHENYLPYRIDAZINE; ACETYLCHOLINE; GRANISETRON; MUSCARINIC M1 RECEPTOR AGONIST; PIRENZEPINE; PYRIDAZINE DERIVATIVE; SEROTONIN 3 ANTAGONIST; SEROTONIN 3 RECEPTOR; UNCLASSIFIED DRUG; MUSCARINIC AGENT; MUSCARINIC RECEPTOR; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING COMPETITION; BRAIN STEM; CONTROLLED STUDY; DRUG COMPETITION; DRUG CONFORMATION; DRUG RECEPTOR BINDING; HEART MUSCLE CELL; HIPPOCAMPUS; NERVE CELL CULTURE; NONHUMAN; RABBIT; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; HEART MUSCLE; IN VITRO STUDY; METABOLISM; PROTEIN CONFORMATION; SYNTHESIS;

ANIMALS; BRAIN STEM; HIPPOCAMPUS; MODELS, MOLECULAR; MUSCARINIC AGONISTS; MYOCARDIUM; PROTEIN CONFORMATION; PYRIDAZINES; RATS; RECEPTORS, MUSCARINIC; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN ANTAGONISTS;

EID: 0032576635     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9705418     Document Type: Article

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